CAJ | 학술논문

目的:探讨正常人血清β-淀粉样肽及载脂蛋白E水平与年龄的相关性. 方法:应用双抗体夹心酶联免疫吸附法(double antibody sandwich enzyme linked immunosorbent assay,ELISA)测定正常中青年人血清Aβ40、Aβ42和及载脂蛋白E(apoli-poprotein E,ApoE)水平含量. 结果:血清β-淀粉样肽40(β-amyloid peptide 40,Aβ40)和Aβ42水平在<39岁组最低,≥39岁且<50岁组最高,≥50岁组低于≥39岁且<50岁组;ApoE水平在≥39岁且<50岁组最低,<39岁组最高. 结论:≥39岁且<50岁组血清ApoE水平降低而Aβ40和Aβ42水平升高.
목적:탐토정상인혈청β-정분양태급재지단백E수평여년령적상관성. 방법:응용쌍항체협심매련면역흡부법(double antibody sandwich enzyme linked immunosorbent assay,ELISA)측정정상중청년인혈청Aβ40、Aβ42화급재지단백E(apoli-poprotein E,ApoE)수평함량. 결과:혈청β-정분양태40(β-amyloid peptide 40,Aβ40)화Aβ42수평재<39세조최저,≥39세차<50세조최고,≥50세조저우≥39세차<50세조;ApoE수평재≥39세차<50세조최저,<39세조최고. 결론:≥39세차<50세조혈청ApoE수평강저이Aβ40화Aβ42수평승고.
Objective:To investigate the correlation between age and the level of serum β-amyloid peptide and apolipoprotein E (ApoE) among the general population. Methods:Double antibody sandwich enzyme linked immunosorbent assay (ELISA) was used to measure the serum level of Aβ40, Aβ42 and ApoE in normal middle-aged and young people. Results:The serum levels of Aβ40 and Aβ42 were the lowest in the <39 age group and the highest in the≥39 and <50 age group, and the levels in the≥50 age group is lower than those in the ≥39 and <50 age group. The level of ApoE is the lowest in the≥39 and <50 age group and the highest in the <39 age group. Conclusion:In the≥39 and <50 age group, the serum level of ApoE decreases and the levels of Aβ40 and Aβ42 increase.