CAJ | 학술논문

目的：探讨临床应用马来酸桂哌齐特治疗急性脑梗死的神经保护作用及中长期预后。方法：90例急性脑梗死患者随机分为马来酸桂哌齐特治疗组(45例)和复方丹参对照组(45例)，比较治疗14d时神经功能评分(美国国立卫生研究院卒中量表评分，NIHSS及日常生活指数Barthel Index)以及血液炎症反应状态，随访90d比较两组患者改良Rankin评分评价中长期预后。结果：应用马来酸桂哌齐特治疗14d后，治疗组NIHSS评分较对照组显著下降，两组患者Barthel指数评分无统计学差异。同时，血液炎性细胞因子水平较对照组有显著下降。随访90d时治疗组改良Rankin评分明显优于对照组。结论：临床应用马来酸桂哌齐特治疗急性脑梗死有神经保护作用，降低炎性反应，改善中长期预后。
목적：탐토림상응용마래산계고제특치료급성뇌경사적신경보호작용급중장기예후。방법：90례급성뇌경사환자수궤분위마래산계고제특치료조(45례)화복방단삼대조조(45례)，비교치료14d시신경공능평분(미국국립위생연구원졸중량표평분，NIHSS급일상생활지수Barthel Index)이급혈액염증반응상태，수방90d비교량조환자개량Rankin평분평개중장기예후。결과：응용마래산계고제특치료14d후，치료조NIHSS평분교대조조현저하강，량조환자Barthel지수평분무통계학차이。동시，혈액염성세포인자수평교대조조유현저하강。수방90d시치료조개량Rankin평분명현우우대조조。결론：림상응용마래산계고제특치료급성뇌경사유신경보호작용，강저염성반응，개선중장기예후。
ABSTRACT:Aim: To investigate the therapeutic efficacy of cinepazide maleate on the acute cerebral infarction and the improvement of the prognosis of the disease. Methods: 90 patients with acute cerebral infarction were randomly divided into two groups, 45 cases treated with cinepazide maleate,45 cases treated with compound salvia miltiorrhiza injection. The scores of NIHSS and Barthel index and the serum inflammatory cytokines were estimated before and in 14 days after the treatment with cinepazide maleate. The score of Rankin scale was estimated in 90 days after the treatment. Results: Comparing to the control group, the score of NIHSS in treatment group was decreased significantly in 14 days after the treatment with cinepazide maleate. The scores of Barthel index were increased in both groups with no significant difference. Meanwhile, the blood inflammatory cytokines were significantly decreased in treatment group. In 90 days after the treatment, the Rankin score indicated that the treatment with cinepazide maleate could greatly improve the prognosis of the disease. Conclusion: The clinical application of cinepazide maleate on the acute cerebral infarction could protect the neurological function, lessen the inflammatory reaction, and improve the prognosis of the disease.