CAJ | 학술논문

目的：探讨妥布霉素地塞米松眼膏联合人工泪液及局部物理治疗的综合策略对睑板腺功能障碍性干眼症的疗效。方法选择我科门诊就诊的睑板腺功能障碍性干眼症患者84例（168眼），随机分成两组：对照组给予聚乙二醇滴眼液联合物理治疗；治疗组在对照组基础上，局部增加妥布霉素地塞米松眼膏。分别比较两组治疗前后主观症状评分、泪液分泌试验（STⅠ）、泪膜破裂时间（BUT）和角膜荧光素染色（FL）评分，评价疗效。结果治疗前两组主观症状、STⅠ、BUT和FL比较差异均无统计学意义（P＞0.05）；治疗4周后，两组STⅠ均有改善，但组间比较差异无统计学意义（P＞0.05）；两组主观症状、BUT和FL均明显改善，组间比较差异均有统计学意义（P＜0.05），两组治愈率分别为42.86%和61.90%，组间比较差异有统计学意义（P＜0.05）。结论妥布霉素地塞米松眼膏联合人工泪液及局部物理治疗的综合策略治疗睑板腺功能障碍性干眼症安全、有效。
목적：탐토타포매소지새미송안고연합인공루액급국부물리치료적종합책략대검판선공능장애성간안증적료효。방법선택아과문진취진적검판선공능장애성간안증환자84례（168안），수궤분성량조：대조조급여취을이순적안액연합물리치료；치료조재대조조기출상，국부증가타포매소지새미송안고。분별비교량조치료전후주관증상평분、루액분비시험（STⅠ）、루막파렬시간（BUT）화각막형광소염색（FL）평분，평개료효。결과치료전량조주관증상、STⅠ、BUT화FL비교차이균무통계학의의（P＞0.05）；치료4주후，량조STⅠ균유개선，단조간비교차이무통계학의의（P＞0.05）；량조주관증상、BUT화FL균명현개선，조간비교차이균유통계학의의（P＜0.05），량조치유솔분별위42.86%화61.90%，조간비교차이유통계학의의（P＜0.05）。결론타포매소지새미송안고연합인공루액급국부물리치료적종합책략치료검판선공능장애성간안증안전、유효。
Objective To explore the efficacy of tobramycin dexamethasone eye ointment combined with artificial tear drops and topical physical treatment on the treatment of meibomian gland dysfunction associated dry eye. Methods 168 eyes (84 cases) of meibomian gland dysfunction associated dry eye in our clinic were randomly divided into two groups, the control group were treated with polyethylene glycol eye drops combined with topical physical therapy , localized tobramycin dexametha-sone eye ointment were added on the basis of control group in the treatment group. Compared the subjective symptom scores , schirmer test (STⅠ), tear film break-up time (BUT), corneal fluorescein staining (FL) score and curative effect of two groups before and after treatment. Results Subjective symptoms, STⅠ, BUT and FL of two groups before treatment had no statisti-cally significant differences(P>0.05). 4 weeks after treatment, STⅠof two groups were all improved, but the difference between two groups had no statistical significance (P>0.05). Subjective symptoms, BUT and FL of two groups were significantly im-proved, the differences between two groups were statistically significant (P<0.05). The curative rate was 42.86% and 61.90%respectively, and the difference was statistically significant (P<0.05). Conclusion The integrated therapy strategy of to-bramycin dexamethasone eye ointment with artificial tear drops and topical physical treatment for meibomian gland dysfunction associated dry eye is safe and effective.