中国现代医药杂志
中國現代醫藥雜誌
중국현대의약잡지
Modern Medicine Journal of China
2015年
11期
1-3
,共3页
何宇晴%刘强%叶震璇%李红梅%杨必伟%张华
何宇晴%劉彊%葉震璇%李紅梅%楊必偉%張華
하우청%류강%협진선%리홍매%양필위%장화
原发性胆汁性肝硬化%抗M2型线粒体抗体%患病率
原髮性膽汁性肝硬化%抗M2型線粒體抗體%患病率
원발성담즙성간경화%항M2형선립체항체%환병솔
Primary biliary cirrhosis%Anti-mitochondrial antibody type M2%Prevalence rate
目的：了解体检人群中原发性胆汁性肝硬化（PBC）患病率及潜在患病风险。方法对2014年3~10月贵州省人民医院11024例体检者血清中抗M2型线粒体抗体（AMA-M2）和血生化指标进行检测。分析PBC的患病率、患病特点、年龄分布及潜在患病风险。结果发现94例抗M2型线粒体抗体阳性，11例可确诊为PBC，患病率为99.78/105；其中男2例，患病率为33.92/105，女9例，患病率为175.54/105，女性患病率高于男性（P<0.05）。11例PBC患者平均年龄（52.36±11.30）岁。年龄分组26～40岁组、41～55岁组与56～70岁组患病率分别为21.32/105、189.75/105和206.90/105，各年龄组患病率之间差异有统计学意义（P<0.05）；26～40岁年龄组患病率低于其余两组（P<0.05），41～55岁组与56～70岁组患病率上差异无统计学意义（P>0.05）。83例AMA-M2阳性、碱性磷酸酶（ALP）正常且无临床症状者，PBC潜在患病率为752.90/105。结合临床资料发现PBC的发病可能与肠道感染、阴道感染、口服激素类药物、吸烟、饮酒相关。结论运用高敏感性和特异性的检测方法是PBC早期诊断的关键。对于AMA-M2阳性、ALP正常且无临床症状者更应加强疾病随访，密切关注病情的变化。 PBC的患病可能与多种风险因素相关，尚需进一步研究。
目的：瞭解體檢人群中原髮性膽汁性肝硬化（PBC）患病率及潛在患病風險。方法對2014年3~10月貴州省人民醫院11024例體檢者血清中抗M2型線粒體抗體（AMA-M2）和血生化指標進行檢測。分析PBC的患病率、患病特點、年齡分佈及潛在患病風險。結果髮現94例抗M2型線粒體抗體暘性，11例可確診為PBC，患病率為99.78/105；其中男2例，患病率為33.92/105，女9例，患病率為175.54/105，女性患病率高于男性（P<0.05）。11例PBC患者平均年齡（52.36±11.30）歲。年齡分組26～40歲組、41～55歲組與56～70歲組患病率分彆為21.32/105、189.75/105和206.90/105，各年齡組患病率之間差異有統計學意義（P<0.05）；26～40歲年齡組患病率低于其餘兩組（P<0.05），41～55歲組與56～70歲組患病率上差異無統計學意義（P>0.05）。83例AMA-M2暘性、堿性燐痠酶（ALP）正常且無臨床癥狀者，PBC潛在患病率為752.90/105。結閤臨床資料髮現PBC的髮病可能與腸道感染、陰道感染、口服激素類藥物、吸煙、飲酒相關。結論運用高敏感性和特異性的檢測方法是PBC早期診斷的關鍵。對于AMA-M2暘性、ALP正常且無臨床癥狀者更應加彊疾病隨訪，密切關註病情的變化。 PBC的患病可能與多種風險因素相關，尚需進一步研究。
목적：료해체검인군중원발성담즙성간경화（PBC）환병솔급잠재환병풍험。방법대2014년3~10월귀주성인민의원11024례체검자혈청중항M2형선립체항체（AMA-M2）화혈생화지표진행검측。분석PBC적환병솔、환병특점、년령분포급잠재환병풍험。결과발현94례항M2형선립체항체양성，11례가학진위PBC，환병솔위99.78/105；기중남2례，환병솔위33.92/105，녀9례，환병솔위175.54/105，녀성환병솔고우남성（P<0.05）。11례PBC환자평균년령（52.36±11.30）세。년령분조26～40세조、41～55세조여56～70세조환병솔분별위21.32/105、189.75/105화206.90/105，각년령조환병솔지간차이유통계학의의（P<0.05）；26～40세년령조환병솔저우기여량조（P<0.05），41～55세조여56～70세조환병솔상차이무통계학의의（P>0.05）。83례AMA-M2양성、감성린산매（ALP）정상차무림상증상자，PBC잠재환병솔위752.90/105。결합림상자료발현PBC적발병가능여장도감염、음도감염、구복격소류약물、흡연、음주상관。결론운용고민감성화특이성적검측방법시PBC조기진단적관건。대우AMA-M2양성、ALP정상차무림상증상자경응가강질병수방，밀절관주병정적변화。 PBC적환병가능여다충풍험인소상관，상수진일보연구。
Objective To study the prevalence rate and the potential risk of primary biliary cirrhosis (PBC) in medical groups. Methods Collected 11 024 cases of physical examination in Guizhou Provincial People's Hospital from Mar to Oct in 2014. Detected anti-mitochondrial antibody type M2 (AMA-M2) and biochemical parameters and analyzed the prevalence of PBC, disease characteristics, age distribution and the potential risk by the method of statistics. Results 94 cases of AMA-M2 was positive, in which 11 cases were diagnosed as PBC, the prevalence rate was 99.78/105. The prevalence rate of PBC was 33.92/105 and 175.54/105 for the males and females,respectively. The prevalence rate of the females was higher than that of the males (P<0.05). The average age of 11 PBC patients was (52.36±11.30) years. The prevalence rate of PBC was 21.32/105, 189.75/105 and 206.90/105 in 26~40, 41~55 and 56~70 years groups,respectively. However,there were significant differences a-mong 3 age groups (P<0.05). 26~40 age group's prevalence rate was lower than the other groups(P<0.05). There was no differ-ence between 41~55 age group and 56~70 age group in the prevalence rate of PBC (P>0.05). AMA-M2 of 83 case was posi-tive,while alkaline phosphatase (ALP) was normal and they had no symptoms in clinic. By analyzing clinical data, the potential prevalence rate of PBC was 752.90/105,the incidence of PBC may be associated with intestinal infections, vaginal infections, o-ral steroids, smoking, drinking. Conclusion The key to early diagnosis of PBC is using high sensitivity and specificity method. The case which AMA-M2 is positive while ALP is normal without clinical symptoms, should be followed up, paid close attention to its changes and progresses. The prevalence of PBC may be associated with a variety of risk factors , needs to be fur-ther study.
