心血管康复医学杂志
心血管康複醫學雜誌
심혈관강복의학잡지
Chinese Journal of Cardiovascular Rehabilitation Medicine
2015年
6期
620-622
,共3页
殷文%刘海燕%王浩宇%刘涛%陈世蓉
慇文%劉海燕%王浩宇%劉濤%陳世蓉
은문%류해연%왕호우%류도%진세용
睾酮%心力衰竭%炎症
睪酮%心力衰竭%炎癥
고동%심력쇠갈%염증
Testosterone%Heart failure%Inflammation
目的：观察老年男性慢性心力衰竭（CHF）患者血浆睾酮与心功能和相关炎症因子水平的相关性。方法：选择我院住院CHF男性患者91例（NYHAⅡ级31例、Ⅲ级30例、Ⅳ级30例）和与之相匹配的男性无CHF患者40例作为无CHF对照组，比较两组血浆睾酮、白介素（IL）‐6、肿瘤坏死因子（TNF）‐α、脑利钠肽（BNP）水平及心功能的差异。结果：与无CHF对照组相比，CHF各亚组血浆睾酮水平均显著下降（P＜0.05或＜0.01），且随着NYHA心功能等级的增加而降低（P＜0.05或＜0.01）；相关分析显示：睾酮水平与IL‐6、TNF‐α水平呈负相关（r＝－0.244、－0.322， P均＜0.05），与LVEF呈正相关（r＝0.322， P＝0.01）。结论：慢性心力衰竭患者心功能越差，血浆睾酮水平越低，测定睾酮水平有助于判断慢性心衰患者心衰的程度及预后情况。
目的：觀察老年男性慢性心力衰竭（CHF）患者血漿睪酮與心功能和相關炎癥因子水平的相關性。方法：選擇我院住院CHF男性患者91例（NYHAⅡ級31例、Ⅲ級30例、Ⅳ級30例）和與之相匹配的男性無CHF患者40例作為無CHF對照組，比較兩組血漿睪酮、白介素（IL）‐6、腫瘤壞死因子（TNF）‐α、腦利鈉肽（BNP）水平及心功能的差異。結果：與無CHF對照組相比，CHF各亞組血漿睪酮水平均顯著下降（P＜0.05或＜0.01），且隨著NYHA心功能等級的增加而降低（P＜0.05或＜0.01）；相關分析顯示：睪酮水平與IL‐6、TNF‐α水平呈負相關（r＝－0.244、－0.322， P均＜0.05），與LVEF呈正相關（r＝0.322， P＝0.01）。結論：慢性心力衰竭患者心功能越差，血漿睪酮水平越低，測定睪酮水平有助于判斷慢性心衰患者心衰的程度及預後情況。
목적：관찰노년남성만성심력쇠갈（CHF）환자혈장고동여심공능화상관염증인자수평적상관성。방법：선택아원주원CHF남성환자91례（NYHAⅡ급31례、Ⅲ급30례、Ⅳ급30례）화여지상필배적남성무CHF환자40례작위무CHF대조조，비교량조혈장고동、백개소（IL）‐6、종류배사인자（TNF）‐α、뇌리납태（BNP）수평급심공능적차이。결과：여무CHF대조조상비，CHF각아조혈장고동수평균현저하강（P＜0.05혹＜0.01），차수착NYHA심공능등급적증가이강저（P＜0.05혹＜0.01）；상관분석현시：고동수평여IL‐6、TNF‐α수평정부상관（r＝－0.244、－0.322， P균＜0.05），여LVEF정정상관（r＝0.322， P＝0.01）。결론：만성심력쇠갈환자심공능월차，혈장고동수평월저，측정고동수평유조우판단만성심쇠환자심쇠적정도급예후정황。
Objective:To observe the correlation among cardiac function ,inflammation factor and plasma testoster‐one level in aged male patients with chronic heart failure (CHF) .Methods :A total of 91 male CHF inpatients were selected from our hospital ,including 31 cases with NYHA cardiac function class Ⅱ ,30 cases with class Ⅲ and 30 ca‐ses with class Ⅳ .Another 40 corresponding male patients without CHF were regarded as non‐CHF control group . Plasma levels of testosterone ,interleukin (IL)‐6 ,tumor necrosis factor (TNF)–α and brain natriuretic peptide (BNP) and cardiac function were compared between two groups .Results:Compared with non‐CHF control group , there were significant reductions in plasma testosterone level , P<0. 05 or 0. 01 ,and they more reduced along with NYHA cardiac function class rose in all CHF subgroups ,P<0.05 or <0.01 .Correlation analysis indicated that tes‐tosterone level was inversely correlated with IL‐6 and TNF‐α levels (r= -0.244 , -0.322 , P<0.05 both) ,and positively correlated with LVEF (r=0.322 ,P=0.01) .Conclusion:In patients with chronic heart failure ,the poo‐rer cardiac function is ,the lower plasma testosterone level is .Testosterone level measurement contributes to judging disease degree and prognosis of patients with chronic heart failure .
