CAJ | 학술논문

目的：分析血清脂联素（APN）、血红素加氧酶‐1（HO‐1）含量与急性冠脉综合征（ACS）患者冠脉病变严重程度的相关性。方法：选择于2013年10月至2014年10月间在本院接受住院治疗的ACS患者78例作为ACS组，根据冠脉病变程度进一步分为单支病变组（15例），双支病变组（37例）和多支病变组（26例），另选择同期在本院接受健康体检的非冠心病人员72例作为非冠心病对照组，检测各组的血清APN、HO‐1含量，分析血清APN、HO‐1含量与冠状动脉病变严重程度的相关性。结果：与非冠心病对照组比较， ACS组血清APN [（15.27±2.31） mg／L比（5.73±0.88） mg／L]、HO‐1[（55.09±8.63）μg／L比（23.17±3.09）μg／L]含量显著降低（P均＜0.01）。与单支病变组比较，双支、多支病变组的血清APN [（9.72±1.13） mg／L比（7.05±0.93） mg／L比（4.23±0.52） mg／L]、HO‐1含量[（38.16±7.52）μg／L比（28.17±5.31）μg／L比（20.32±3.28）μg／L]显著降低，且多支病变组的显著低于双支病变组的（P＜0.05或＜0.01）。线性回归分析显示血清APN、HO‐1含量与冠脉病变严重程度呈显著负相关（ B＝－2.869，－2.742， P分别＜0.05，＜0.01）。结论：急性冠脉综合征患者血清APN、HO‐1含量显著降低，且其水平与冠脉病变严重程度呈显著负相关，有助于对患者的病情判断及治疗指导。
목적：분석혈청지련소（APN）、혈홍소가양매‐1（HO‐1）함량여급성관맥종합정（ACS）환자관맥병변엄중정도적상관성。방법：선택우2013년10월지2014년10월간재본원접수주원치료적ACS환자78례작위ACS조，근거관맥병변정도진일보분위단지병변조（15례），쌍지병변조（37례）화다지병변조（26례），령선택동기재본원접수건강체검적비관심병인원72례작위비관심병대조조，검측각조적혈청APN、HO‐1함량，분석혈청APN、HO‐1함량여관상동맥병변엄중정도적상관성。결과：여비관심병대조조비교， ACS조혈청APN [（15.27±2.31） mg／L비（5.73±0.88） mg／L]、HO‐1[（55.09±8.63）μg／L비（23.17±3.09）μg／L]함량현저강저（P균＜0.01）。여단지병변조비교，쌍지、다지병변조적혈청APN [（9.72±1.13） mg／L비（7.05±0.93） mg／L비（4.23±0.52） mg／L]、HO‐1함량[（38.16±7.52）μg／L비（28.17±5.31）μg／L비（20.32±3.28）μg／L]현저강저，차다지병변조적현저저우쌍지병변조적（P＜0.05혹＜0.01）。선성회귀분석현시혈청APN、HO‐1함량여관맥병변엄중정도정현저부상관（ B＝－2.869，－2.742， P분별＜0.05，＜0.01）。결론：급성관맥종합정환자혈청APN、HO‐1함량현저강저，차기수평여관맥병변엄중정도정현저부상관，유조우대환자적병정판단급치료지도。
Objective:To analyze the correlation among serum adiponectin (APN) ,heme oxygenase‐1 (HO‐1) con‐centrations and severity of coronary lesion in patients with acute coronary syndrome (ACS) .Methods :A total of 78 ACS patients ,who hospitalized and received therapy in our hospital from Oct 2013 to Oct 2014 ,were enrolled as ACS group .According to severity of coronary lesion ,they were further divided into single vessel coronary disease group (single vessel group ,n=15) ,double‐vessel coronary disease group (double‐vessel group ,n=37) and multi‐vessel coronary disease group (multi‐vessel group , n = 26 ) . Another 72 subjects without coronary heart disease (CHD) ,who received physical examination in our hospital during the same period ,were selected as non‐CHD con‐trol group .Serum concentrations of APN and HO‐1 were measured in all groups . The correlation among serum APN ,HO‐1 concentrations and severity of coronary lesion were analyzed .Results:Compared with non‐CHD con‐trol group ,there were significant reductions in serum concentrations of APN [ (15.27 ± 2.31) mg/L vs .(5.73 ± 0.88) mg/L] and HO‐1 [ (55.09 ± 8.63)μg/L vs .(23.17 ± 3.09)μg/L] in ACS group ,P<0.01 both .Compared with single vessel group ,there were significant reductions in serum concentrations of APN [(9.72 ± 1.13) mg/L vs . (7.05 ± 0.93) mg/L vs .(4.23 ± 0.52) mg/L] and HO‐1 [(38.16 ± 7.52)μg/L vs .(28.17 ± 5.31)μg/L vs .(20.32 ± 3.28)μg/L] in double‐vessel group and multi‐vessel group ,and those of multi‐vessel group were significantly low‐er than those of double‐vessel group ,P<0.05 or <0.01 .Linear regression analysis indicated that serum concentra‐tions of APN and HO‐1 were significant inversely correlated with severity of coronary lesion (B= -2.869 , -2.742 , P<0.05 ,<0.01 respectively) .Conclusion:Serum concentrations of APN and HO‐1 significantly reduce in ACS patients ,and their levels are significant inversely correlated with severity of coronary lesion ,so they are help‐ful to judging patient's condition and guiding treatment .