心血管康复医学杂志
心血管康複醫學雜誌
심혈관강복의학잡지
Chinese Journal of Cardiovascular Rehabilitation Medicine
2015年
6期
614-616
,共3页
冠心病%颈动脉疾病%C反应蛋白质
冠心病%頸動脈疾病%C反應蛋白質
관심병%경동맥질병%C반응단백질
Coronary disease%Carotid artery diseases%C-reactive protein
目的:探讨冠心病患者冠状动脉病变与颈动脉内膜中层厚度(IMT )和斑块积分以及血浆 C反应蛋白(CRP)水平的关系。方法:选择冠心病患者(83例,冠心病组)与非冠心病患者(37例,非冠心病组),对冠心病患者进行冠脉造影,根据冠脉病变血管数冠心病患者又被分为:单支病变组(28例)、双支病变组(31例)及三支病变组(24例)。检测各组患者C反应蛋白(CRP)水平,颈动脉内膜中层厚度(IMT),并对颈动脉粥样硬化斑块进行分级。结果:与非冠心病组比较,冠心病组患者CRP水平[(0.89±0.54) mg/L比(3.50±3.42) mg/L]、IMT [(0.65±0.27) mm比(1.04±0.31) mm]明显增加(P<0.05或<0.01);与单支病变组和双支病变组比较,三支病变组的CRP水平[(1.44±1.03) mg/L ,(3.71±3.52) mg/L比(5.82±3.98) mg/L]显著升高,颈动脉斑块3级比例(0%、0%比25%)显著升高( P均<0.01)。结论:冠心病患者C反应蛋白水平及颈动脉内膜中层厚度明显增加,且多支病变者C反应蛋白水平及颈动脉粥样硬化斑块3级比例明显增加。
目的:探討冠心病患者冠狀動脈病變與頸動脈內膜中層厚度(IMT )和斑塊積分以及血漿 C反應蛋白(CRP)水平的關繫。方法:選擇冠心病患者(83例,冠心病組)與非冠心病患者(37例,非冠心病組),對冠心病患者進行冠脈造影,根據冠脈病變血管數冠心病患者又被分為:單支病變組(28例)、雙支病變組(31例)及三支病變組(24例)。檢測各組患者C反應蛋白(CRP)水平,頸動脈內膜中層厚度(IMT),併對頸動脈粥樣硬化斑塊進行分級。結果:與非冠心病組比較,冠心病組患者CRP水平[(0.89±0.54) mg/L比(3.50±3.42) mg/L]、IMT [(0.65±0.27) mm比(1.04±0.31) mm]明顯增加(P<0.05或<0.01);與單支病變組和雙支病變組比較,三支病變組的CRP水平[(1.44±1.03) mg/L ,(3.71±3.52) mg/L比(5.82±3.98) mg/L]顯著升高,頸動脈斑塊3級比例(0%、0%比25%)顯著升高( P均<0.01)。結論:冠心病患者C反應蛋白水平及頸動脈內膜中層厚度明顯增加,且多支病變者C反應蛋白水平及頸動脈粥樣硬化斑塊3級比例明顯增加。
목적:탐토관심병환자관상동맥병변여경동맥내막중층후도(IMT )화반괴적분이급혈장 C반응단백(CRP)수평적관계。방법:선택관심병환자(83례,관심병조)여비관심병환자(37례,비관심병조),대관심병환자진행관맥조영,근거관맥병변혈관수관심병환자우피분위:단지병변조(28례)、쌍지병변조(31례)급삼지병변조(24례)。검측각조환자C반응단백(CRP)수평,경동맥내막중층후도(IMT),병대경동맥죽양경화반괴진행분급。결과:여비관심병조비교,관심병조환자CRP수평[(0.89±0.54) mg/L비(3.50±3.42) mg/L]、IMT [(0.65±0.27) mm비(1.04±0.31) mm]명현증가(P<0.05혹<0.01);여단지병변조화쌍지병변조비교,삼지병변조적CRP수평[(1.44±1.03) mg/L ,(3.71±3.52) mg/L비(5.82±3.98) mg/L]현저승고,경동맥반괴3급비례(0%、0%비25%)현저승고( P균<0.01)。결론:관심병환자C반응단백수평급경동맥내막중층후도명현증가,차다지병변자C반응단백수평급경동맥죽양경화반괴3급비례명현증가。
Objective:To explore the relationship among carotid intima‐media thickness (IMT) ,plaque score ,plasma level of C reactive protein (CRP) and coronary artery lesion in patients with coronary heart disease (CHD) .Meth‐ods:A total of 83 CHD patients were enrolled as CHD group and 37 patients without CHD were enrolled as non‐CHD group .CHD patients received coronary angiography .According to number of diseased coronary vessels ,CHD patients were divided into single vessel coronary disease group (n=28 ,single vessel group ) ,double‐vessel coronary disease group (n=31 ,double‐vessel group) and triple‐vessel coronary disease group (n= 24 ,triple‐vessel group) . Plasma CRP level and carotid IMT were measured ,and carotid atherosclerotic plaques were classified in all groups . Results :Compared with non‐CHD group ,there were significant rise in CRP level [ (0.89 ± 0.54) mg/L vs . (3.50 ± 3.42) mg/L] and IMT [ (0.65 ± 0.27) mm vs . (1.04 ± 0.31) mm] in CHD group (P<0.05 or <0.01);Com‐pared with single‐vessel group and double‐vessel group ,the CRP level of triple‐vessel group [ (1.44 ± 1.03) mg/L , (3.71 ± 3.52) mg/L vs .5.82 ± 3.98) mg/L] significantly rose ;the percentage of carotid plaque class 3 of triple‐ves‐sel group (0% 、0% vs .25% ) significantly rose (P<0.01 all) .Conclusion:C reactive protein level and carotid intima‐media thickness significantly rise in patients with coronary heart disease ,and there are significant rise in C reactive protein level and percentage of carotid atherosclerotic plaque class 3 in patients with multi‐vessel coronary disease .