中国社区医师
中國社區醫師
중국사구의사
Chinese Community Doctors
2015年
34期
24-25
,共2页
N-乙酰半胱氨酸%氯米芬%多囊卵巢综合征
N-乙酰半胱氨痠%氯米芬%多囊卵巢綜閤徵
N-을선반광안산%록미분%다낭란소종합정
N-acetylcysteine%Clomiphene%Polycystic ovary syndrome
目的：探讨N-乙酰半胱氨酸治疗氯米芬抵抗多囊卵巢综合征的临床效果。方法：收治氯米芬抵抗多囊卵巢综合征患者40例，随机分为观察组和对照组各20例。对照组均在月经来潮或撤退性出血第5天口服促排卵药，连服5 d，同时给予叶酸、氯米芬5 mg/d。观察组口服NAC 1.8～3.0 g/d，两组均连用5～6周。观察两组的临床效果。结果：观察组子宫内膜厚度(7.81±1.20)mm，成熟卵泡发育17例(85.0%)，排卵16例(80.0%)，妊娠13例(65.0%)；对照组子宫内膜厚度(9.01±2.01)mm，成熟卵泡发育13例(65.0%)，排卵9例(45.0%)，妊娠2例(10.0%)。两组比较，差异具有统计学意义(P＜0.05)。对照组不良反应2例，不良反应发生率10.0%，观察组未见不良反应，两组比较，差异有统计学意义(P＜0.05)。结论：N-乙酰半胱氨酸治疗氯米芬抵抗多囊卵巢综合征具有显著疗效，大大提高了受孕率。
目的：探討N-乙酰半胱氨痠治療氯米芬牴抗多囊卵巢綜閤徵的臨床效果。方法：收治氯米芬牴抗多囊卵巢綜閤徵患者40例，隨機分為觀察組和對照組各20例。對照組均在月經來潮或撤退性齣血第5天口服促排卵藥，連服5 d，同時給予葉痠、氯米芬5 mg/d。觀察組口服NAC 1.8～3.0 g/d，兩組均連用5～6週。觀察兩組的臨床效果。結果：觀察組子宮內膜厚度(7.81±1.20)mm，成熟卵泡髮育17例(85.0%)，排卵16例(80.0%)，妊娠13例(65.0%)；對照組子宮內膜厚度(9.01±2.01)mm，成熟卵泡髮育13例(65.0%)，排卵9例(45.0%)，妊娠2例(10.0%)。兩組比較，差異具有統計學意義(P＜0.05)。對照組不良反應2例，不良反應髮生率10.0%，觀察組未見不良反應，兩組比較，差異有統計學意義(P＜0.05)。結論：N-乙酰半胱氨痠治療氯米芬牴抗多囊卵巢綜閤徵具有顯著療效，大大提高瞭受孕率。
목적：탐토N-을선반광안산치료록미분저항다낭란소종합정적림상효과。방법：수치록미분저항다낭란소종합정환자40례，수궤분위관찰조화대조조각20례。대조조균재월경래조혹철퇴성출혈제5천구복촉배란약，련복5 d，동시급여협산、록미분5 mg/d。관찰조구복NAC 1.8～3.0 g/d，량조균련용5～6주。관찰량조적림상효과。결과：관찰조자궁내막후도(7.81±1.20)mm，성숙란포발육17례(85.0%)，배란16례(80.0%)，임신13례(65.0%)；대조조자궁내막후도(9.01±2.01)mm，성숙란포발육13례(65.0%)，배란9례(45.0%)，임신2례(10.0%)。량조비교，차이구유통계학의의(P＜0.05)。대조조불량반응2례，불량반응발생솔10.0%，관찰조미견불량반응，량조비교，차이유통계학의의(P＜0.05)。결론：N-을선반광안산치료록미분저항다낭란소종합정구유현저료효，대대제고료수잉솔。
Objective:To explore the clinical effect of N-acetylcysteine in the treatment of clomiphene resistant polycystic ovary syndrome.Methods:40 patients with clomiphene resistant polycystic ovary syndrome were selected.They were randomly divided into the observation group and the control group with 20 cases in each.The control group was given oral stimulate ovulation medicine at menses or fifth day of retreat hemorrhages,taking for 5 days,and given folic acid,clomiphene 5mg one day.The observation group was given oral NAC 1.8~3.0 g one day.The two groups were used for 5 to 6 weeks.The clinical effects of two groups were observed.Results:In the observation group,the endometrial thickness was (7.81 ± 1.20)mm,17 cases(85.0% ) had mature follicle development,16 cases(80.0%) had ovulation,13 cases(65.0%) had pregnancy.In the control group,the endometrial thickness was (9.01±2.01)mm,13 cases(65.0%) had mature follicle development,9 cases(45.0%) had ovulation,2 cases(10.0%) had pregnancy.The difference between the two groups was statistically significant(P<0.05).The control group had 2 cases of adverse reaction,the adverse reaction incidence rate was 10%.The observation group showed no adverse reaction.The difference was statistically significant between the two groups(P<0.05).Conclusion:N-acetylcysteine in the treatment of clomiphene resistant polycystic ovary syndrome has a significant curative effect,greatly increases the pregnancy rate.
