湖北民族学院学报（医学版）
湖北民族學院學報（醫學版）
호북민족학원학보（의학판）
Journal of Hubei University for Nationalities (Medical Edition)
2015年
4期
42-44
,共3页
阿曲库铵%神经肌肉阻滞%温度
阿麯庫銨%神經肌肉阻滯%溫度
아곡고안%신경기육조체%온도
Atracurium%neuromuscular blockade%temperature%time factors
目的：评价不同贮存方法对苯磺顺阿曲库铵肌松效应的影响。方法择期全麻手术患者90例，采用随机数字表法将患者分为3组（n＝30）：低温组（A组）、常温组（B组）、常低温交替组（C组）。苯磺顺阿曲库铵置于低温冰箱2～4℃贮存30d（A组）、常温（22～25℃）存放30d（B组）或每天12h常低温交替存放30d（C组）。采用TOF－Watch SX肌松监测仪，采用单次超强电刺激观察拇内收肌的肌松程度。意识消失后静脉注射苯磺顺阿曲库铵0.2 mg／kg，当肌颤搐达到最大抑制时行气管插管。记录苯磺顺阿曲库铵起效时间、临床作用时间、恢复指数和75％恢复时间并评价气管插管条件。结果与A组比较，B组、C组苯磺顺阿曲库铵起效时间延长，临床作用时间、75％恢复时间和恢复指数缩短（ P＜0.05）。 A组气管插管条件优良，B组、C组气管插管条件差，差异有统计学意义（ P＜0.05）。结论室温贮存及常低温交替贮存30 d均可降低苯磺顺阿曲库铵肌松效应。
目的：評價不同貯存方法對苯磺順阿麯庫銨肌鬆效應的影響。方法擇期全痳手術患者90例，採用隨機數字錶法將患者分為3組（n＝30）：低溫組（A組）、常溫組（B組）、常低溫交替組（C組）。苯磺順阿麯庫銨置于低溫冰箱2～4℃貯存30d（A組）、常溫（22～25℃）存放30d（B組）或每天12h常低溫交替存放30d（C組）。採用TOF－Watch SX肌鬆鑑測儀，採用單次超彊電刺激觀察拇內收肌的肌鬆程度。意識消失後靜脈註射苯磺順阿麯庫銨0.2 mg／kg，噹肌顫搐達到最大抑製時行氣管插管。記錄苯磺順阿麯庫銨起效時間、臨床作用時間、恢複指數和75％恢複時間併評價氣管插管條件。結果與A組比較，B組、C組苯磺順阿麯庫銨起效時間延長，臨床作用時間、75％恢複時間和恢複指數縮短（ P＜0.05）。 A組氣管插管條件優良，B組、C組氣管插管條件差，差異有統計學意義（ P＜0.05）。結論室溫貯存及常低溫交替貯存30 d均可降低苯磺順阿麯庫銨肌鬆效應。
목적：평개불동저존방법대분광순아곡고안기송효응적영향。방법택기전마수술환자90례，채용수궤수자표법장환자분위3조（n＝30）：저온조（A조）、상온조（B조）、상저온교체조（C조）。분광순아곡고안치우저온빙상2～4℃저존30d（A조）、상온（22～25℃）존방30d（B조）혹매천12h상저온교체존방30d（C조）。채용TOF－Watch SX기송감측의，채용단차초강전자격관찰무내수기적기송정도。의식소실후정맥주사분광순아곡고안0.2 mg／kg，당기전휵체도최대억제시행기관삽관。기록분광순아곡고안기효시간、림상작용시간、회복지수화75％회복시간병평개기관삽관조건。결과여A조비교，B조、C조분광순아곡고안기효시간연장，림상작용시간、75％회복시간화회복지수축단（ P＜0.05）。 A조기관삽관조건우량，B조、C조기관삽관조건차，차이유통계학의의（ P＜0.05）。결론실온저존급상저온교체저존30 d균가강저분광순아곡고안기송효응。
Objective To evaluate the efects of diferent storage methods on cisatracurium-in-duced neuromuscular block.Methods Ninety ASA I orⅡpatients,aged 20~53,scheduled for e-lective gynecological operations under general anesthesia,were randomly divided into 3 groups ( n=30 each):cisatracurium stored for 30 days at 2~4℃group( group A) ,cisatracurium stored for 30 days at room temperature group ( group B) and cisatracurium stored for 30 days at room temperature group and 2~4℃,12 h in turn ( group C) .Anesthesia was induced with iv injection of midazolam and target-controlled infusion of propofol( target plasma concentration 3μg/mL) and remifentanil( target efect-site concentration 3~5 ng/mL) .A bolus of cisatracurium 0.2 mg/kg was given intravenously over 5~10 S as soon as the patients lost consciousness.Neuromus-cular block was monitored with TOF-Watch SX( Organon,Netherlands) .Single stimulation was applied to the ulnar nerve at wrist.The maximal degree of neuromuscular block,onset time,clin-ical duration,recovery index and 75%recovery time were recorded.The patients were intubated and mechanically ventilated when neuromuscular block reached the maximal degree.The intuba-tion condition was evaluated.Results Compared with group A,the onset time was significantly prolonged,clinical duration, recovery index and 75%recovery time were shortened in group B and group C ( P<0.05) .The intubation condition was excellent or good in group A and there was no significant difference among group B and group C.Conclusion The neuromuscular block of ci-satracurium is significantly attenuated when stored for 30 days at room temperature or room temperature and 2~4℃alternately.
