CAJ | 학술논문

目的：研究蛇竭颗粒对神经根型颈椎病大鼠模型血清一氧化氮（ NO）、血浆内皮素（ ET）含量的影响。方法采用颈椎插线法建立大鼠神经根型颈椎病模型，将50只正常Wistar大鼠，随机分为模型组、假手术组、颈复康颗粒对照组、蛇竭颗粒高剂量组和蛇竭颗粒低剂量组，测定各组NO、ET的含量。结果治疗28 d后，蛇竭颗粒高、低剂量组及颈复康对照组血清NO含量显著升高，血浆内皮素含量明显下降，与治疗前比较有显著性意义（ P＜0．05）。治疗后蛇竭颗粒高、低剂量组及颈复康对照组血清NO含量与模型组比较有显著差异（ P＜0．01）；蛇竭颗粒高、低剂量组及颈复康对照组的血浆ET含量治疗后明显低于模型组（ P＜0．01），蛇竭颗粒高剂量组血浆ET含量的明显高于颈复康对照组（ P＜0．05）。结论蛇竭颗粒可影响内皮细胞活性因子NO、ET水平及含量的变化，对颈椎病有积极治疗作用。
목적：연구사갈과립대신경근형경추병대서모형혈청일양화담（ NO）、혈장내피소（ ET）함량적영향。방법채용경추삽선법건립대서신경근형경추병모형，장50지정상Wistar대서，수궤분위모형조、가수술조、경복강과립대조조、사갈과립고제량조화사갈과립저제량조，측정각조NO、ET적함량。결과치료28 d후，사갈과립고、저제량조급경복강대조조혈청NO함량현저승고，혈장내피소함량명현하강，여치료전비교유현저성의의（ P＜0．05）。치료후사갈과립고、저제량조급경복강대조조혈청NO함량여모형조비교유현저차이（ P＜0．01）；사갈과립고、저제량조급경복강대조조적혈장ET함량치료후명현저우모형조（ P＜0．01），사갈과립고제량조혈장ET함량적명현고우경복강대조조（ P＜0．05）。결론사갈과립가영향내피세포활성인자NO、ET수평급함량적변화，대경추병유적겁치료작용。
Objective To investigate the effects of Shejie granules on serum nitric oxide ( NO) and plasma endothelin ( ET) in rat model with nerve root cervical spondylosis.Methods The rat model with nerve root cervical spondylosis was established by intervertebral nylon suture inser-ting method.The 50 cases of normal Wistar rats were randomly divided into model group,sham operation group, control group treated with Jingfukang granules and treatment group treated with high-dosed and low-dosed Shejie granules, respectively.The NO and ET levels in each group were observed.Results After treatment,the NO and ET levels in both treatment and con-trol group were improved more significantly than those in both model and sham operation group (P<0.05).In addition,the effect in treatment group treated with high-dosed Shejie granules was better than that in control group treated with Jingfukang granules ( P<0.05) .Conclusion The Shejie granules can influence the levels and contents of active factors of NO and ET in endothe-lial cell and have positive therapeutic effect on cervical spondylosis.