CAJ | 학술논문

目的：观察心理干预联合帕罗西汀治疗冠脉造影阴性伴焦虑抑郁患者躯体症状改善与焦虑抑郁情绪的相关性以及不同治疗方案的临床疗效。方法将84例冠脉造影阴性伴焦虑、抑郁情绪出院诊断为心神经症的患者随机分为两组，对照组42例，治疗组42例。对照组仅给予心理干预治疗，治疗组在心理干预基础上给予盐酸帕罗西汀20mg 每日早上一次，两组均在治疗前，治疗后8周分别采用症状自评量表（SCL-90）、汉密尔顿焦虑量表（HAMA）、汉密尔顿抑郁量表（HAMD）进行疗效评定。结果治疗8周后治疗组和对照组躯体症状减分率与 HAMA、HAMD 减分率呈正相关（相关系数分别为0.842，0.851，P<0.05）,治疗8周后治疗组和对照组HAMA、HAMD减分率比较有差异有统计学意义（P<0.05）。结论冠脉造影阴性伴焦虑、抑郁的患者抗焦虑、抑郁治疗后躯体症状得到有效缓解，这些患者躯体症状的缓解与焦虑抑郁症状的改善存在明显的相关性。帕罗西汀联合心理治疗冠脉造影阴性伴焦虑、抑郁的患者临床疗效显著。
목적：관찰심리간예연합파라서정치료관맥조영음성반초필억욱환자구체증상개선여초필억욱정서적상관성이급불동치료방안적림상료효。방법장84례관맥조영음성반초필、억욱정서출원진단위심신경증적환자수궤분위량조，대조조42례，치료조42례。대조조부급여심리간예치료，치료조재심리간예기출상급여염산파라서정20mg 매일조상일차，량조균재치료전，치료후8주분별채용증상자평량표（SCL-90）、한밀이돈초필량표（HAMA）、한밀이돈억욱량표（HAMD）진행료효평정。결과치료8주후치료조화대조조구체증상감분솔여 HAMA、HAMD 감분솔정정상관（상관계수분별위0.842，0.851，P<0.05）,치료8주후치료조화대조조HAMA、HAMD감분솔비교유차이유통계학의의（P<0.05）。결론관맥조영음성반초필、억욱적환자항초필、억욱치료후구체증상득도유효완해，저사환자구체증상적완해여초필억욱증상적개선존재명현적상관성。파라서정연합심리치료관맥조영음성반초필、억욱적환자림상료효현저。
Objective To investigate the psychological intervention combined with paroxetine in the treatment of coronary angiography negative correlation with anxiety and clinical efficacy of different treatment regimens of patients with depression and somatic symptoms of anxiety and depression. Methods 84 patients with negative coronary angiography with anxiety, depression discharge diagnosis of cardiac neurosis were randomly divided into two groups, 42 cases, 42 cases of treatment group. The control group received psychological intervention, treatment group received paroxetine hydrochloride 20mg once daily in the morning, both groups before and after treatment eight weeks respectively Symptom Checklist (SCL-90) on the basis of psychological intervention on Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD) efficacy evaluation. Results After 8 weeks of treatment and control groups reduced rate of somatic symptoms and HAMA, HAMD reduction rate was positively correlated (correlation coefficients were 0.842,0.851, P<0.05), the treatment of eight weeks after the treatment and control groups HAMA, HAMD reduction rate there are differences statistically significant (P <0.05). Conclusions Coronary angiography negative with anxiety and depression in patients with anti-anxiety, depression and post-treatment effectively alleviate the physical symptoms, the presence of somatic symptoms in these patients improve ease with anxiety and depression symptoms significantly correlated. Paroxetine plus psychotherapy negative coronary angiography with anxiety, clinical efficacy in patients with significant depression.