山西中医学院学报
山西中醫學院學報
산서중의학원학보
Journal of Shanxi College of Traditional Chinese Medicine
2015年
5期
20-26
,共7页
阙金花%黄鸣清%郑海音%徐伟%李煌%洪振丰%许舒瑜%刘杰%林诗瑶
闕金花%黃鳴清%鄭海音%徐偉%李煌%洪振豐%許舒瑜%劉傑%林詩瑤
궐금화%황명청%정해음%서위%리황%홍진봉%허서유%류걸%림시요
复方熊胆茵陈颗粒%水提醇沉%正交试验%绿原酸%柴胡皂苷a
複方熊膽茵陳顆粒%水提醇沉%正交試驗%綠原痠%柴鬍皂苷a
복방웅담인진과립%수제순침%정교시험%록원산%시호조감a
compound Xiongdan Yinchen particles%water extracting-alcohol precipitating%orthogonal test%chlorogenic acid%saikosaponin a
目的：优选复方熊胆茵陈颗粒的水提醇沉工艺条件。方法：以绿原酸、柴胡皂苷a的含量和浸膏得率为考察指标，正交试验法优选水提醇沉最佳工艺条件。结果：最佳水提醇沉条件为加8倍量水提取2次，每次1.5 h；醇沉药液相对密度1.2（50℃），醇沉乙醇浓度为70%，醇沉时间24 h。结论：该优选工艺方法简便、稳定可行，可作为复方熊胆茵陈颗粒的提取纯化工艺。
目的：優選複方熊膽茵陳顆粒的水提醇沉工藝條件。方法：以綠原痠、柴鬍皂苷a的含量和浸膏得率為攷察指標，正交試驗法優選水提醇沉最佳工藝條件。結果：最佳水提醇沉條件為加8倍量水提取2次，每次1.5 h；醇沉藥液相對密度1.2（50℃），醇沉乙醇濃度為70%，醇沉時間24 h。結論：該優選工藝方法簡便、穩定可行，可作為複方熊膽茵陳顆粒的提取純化工藝。
목적：우선복방웅담인진과립적수제순침공예조건。방법：이록원산、시호조감a적함량화침고득솔위고찰지표，정교시험법우선수제순침최가공예조건。결과：최가수제순침조건위가8배량수제취2차，매차1.5 h；순침약액상대밀도1.2（50℃），순침을순농도위70%，순침시간24 h。결론：해우선공예방법간편、은정가행，가작위복방웅담인진과립적제취순화공예。
Objective:To optimize technology conditions of water extracting-alcohol precipitating of compound Xiongdan Yinchen particles. Methods:Orthogonal test was adopted and the contents of chlorogenic acid,saikosaponin a and the yield of extractum were as indices. Results:The optimum technology conditions were as follows:8 times quantity of water extracts 2 times,1 times per 1.5 h;the relative density of alcohol precipitation solution was 1.2 (50℃),the concentration of alcohol was 70%,and the alcohol precipitation time was 24 h. Conclusion:The optimization method is simple and stable,could be used as the technology of extraction and purification of compound Xiongdan Yinchen particles.
