中华诊断学电子杂志
中華診斷學電子雜誌
중화진단학전자잡지
Chinese Journal of Diagnostics (Electronic Edition)
2015年
4期
274-278
,共5页
张同梅%鲁葆华%秦娜%贾文蕴%钱哲%郑华%胡瑛%仝丽%李雪冰%王敬萍%张红梅%李宝兰
張同梅%魯葆華%秦娜%賈文蘊%錢哲%鄭華%鬍瑛%仝麗%李雪冰%王敬萍%張紅梅%李寶蘭
장동매%로보화%진나%가문온%전철%정화%호영%동려%리설빙%왕경평%장홍매%리보란
肺肿瘤%癌,非小细胞肺%胸苷酸合酶%预后
肺腫瘤%癌,非小細胞肺%胸苷痠閤酶%預後
폐종류%암,비소세포폐%흉감산합매%예후
Lung neoplasms%Carcinoma,non-small cell lung%Thymidylate synthase%Prognosis
目的:探讨非小细胞肺癌患者肿瘤组织中胸苷酸合成酶( TS)的表达水平与年龄及其他临床病理特征之间的关系。方法回顾分析2008年3月至2009年10月在首都医科大学附属北京胸科医院肿瘤科住院,且经外科手术确诊的302例非小细胞肺癌( NSCLC)患者的临床资料及石蜡包埋的肿瘤组织标本。将患者按年龄分为3组:≤45岁组,46~69岁组,≥70岁组;用免疫组化( IHC)半定量法测定瘤组织中TS的表达,IHC得分范围0~9分,按IHC得分分为低表达(0~3分)和高表达(>3分)。采用SPSS 17.0软件对资料进行统计分析,不同组别TS表达率的显著性检验采用χ2检验;患者年龄和肿瘤组织分化程度符合正态分布,其与IHC得分的相关性采用Pearson相关分析法进行分析。结果302例患者中鳞癌140(46.4%)例,非鳞癌162(53.6%)例。 TS高表达在鳞癌32.1%(45/140),非鳞癌29.0%(47/162)中,差异无统计学意义(χ2=0.35, P=0.556)。不同年龄组患者肿瘤组织TS高表达率分别为:≤45岁组45.2%(14/31)、46~69岁组31.7%(70/221)和≥70岁组16.0%(8/50),差异有统计学意义(χ2=8.52, P =0.016)。287例NSCLC患者病理有分化程度,低分化和中高分化肿瘤组织TS高表达率分别为37.8%(37/98)和25.4%(48/189),差异有统计学意义(χ2=4.73, P =0.030)。相关性分析显示年龄与IHC得分呈负相关( r =-0.15, P =0.010);分化程度与IHC得分无关( r =-0.11, P =0.057)。 NSCLC患者不同病理类型性别、吸烟指数、肿瘤大小、TNM分期和有无淋巴结转移间TS蛋白表达水平,均差异无统计学意义(χ2=0.35,0.85,0.41,0.01,0.16,0.67;P>0.05)。结论 NSCLC瘤组织表达TS水平高低与年龄和肿瘤分化程度相关;不同年龄组患者和不同分化程度的肿瘤组织TS表达的水平有差异,仅年龄与TS的表达呈负相关。
目的:探討非小細胞肺癌患者腫瘤組織中胸苷痠閤成酶( TS)的錶達水平與年齡及其他臨床病理特徵之間的關繫。方法迴顧分析2008年3月至2009年10月在首都醫科大學附屬北京胸科醫院腫瘤科住院,且經外科手術確診的302例非小細胞肺癌( NSCLC)患者的臨床資料及石蠟包埋的腫瘤組織標本。將患者按年齡分為3組:≤45歲組,46~69歲組,≥70歲組;用免疫組化( IHC)半定量法測定瘤組織中TS的錶達,IHC得分範圍0~9分,按IHC得分分為低錶達(0~3分)和高錶達(>3分)。採用SPSS 17.0軟件對資料進行統計分析,不同組彆TS錶達率的顯著性檢驗採用χ2檢驗;患者年齡和腫瘤組織分化程度符閤正態分佈,其與IHC得分的相關性採用Pearson相關分析法進行分析。結果302例患者中鱗癌140(46.4%)例,非鱗癌162(53.6%)例。 TS高錶達在鱗癌32.1%(45/140),非鱗癌29.0%(47/162)中,差異無統計學意義(χ2=0.35, P=0.556)。不同年齡組患者腫瘤組織TS高錶達率分彆為:≤45歲組45.2%(14/31)、46~69歲組31.7%(70/221)和≥70歲組16.0%(8/50),差異有統計學意義(χ2=8.52, P =0.016)。287例NSCLC患者病理有分化程度,低分化和中高分化腫瘤組織TS高錶達率分彆為37.8%(37/98)和25.4%(48/189),差異有統計學意義(χ2=4.73, P =0.030)。相關性分析顯示年齡與IHC得分呈負相關( r =-0.15, P =0.010);分化程度與IHC得分無關( r =-0.11, P =0.057)。 NSCLC患者不同病理類型性彆、吸煙指數、腫瘤大小、TNM分期和有無淋巴結轉移間TS蛋白錶達水平,均差異無統計學意義(χ2=0.35,0.85,0.41,0.01,0.16,0.67;P>0.05)。結論 NSCLC瘤組織錶達TS水平高低與年齡和腫瘤分化程度相關;不同年齡組患者和不同分化程度的腫瘤組織TS錶達的水平有差異,僅年齡與TS的錶達呈負相關。
목적:탐토비소세포폐암환자종류조직중흉감산합성매( TS)적표체수평여년령급기타림상병리특정지간적관계。방법회고분석2008년3월지2009년10월재수도의과대학부속북경흉과의원종류과주원,차경외과수술학진적302례비소세포폐암( NSCLC)환자적림상자료급석사포매적종류조직표본。장환자안년령분위3조:≤45세조,46~69세조,≥70세조;용면역조화( IHC)반정량법측정류조직중TS적표체,IHC득분범위0~9분,안IHC득분분위저표체(0~3분)화고표체(>3분)。채용SPSS 17.0연건대자료진행통계분석,불동조별TS표체솔적현저성검험채용χ2검험;환자년령화종류조직분화정도부합정태분포,기여IHC득분적상관성채용Pearson상관분석법진행분석。결과302례환자중린암140(46.4%)례,비린암162(53.6%)례。 TS고표체재린암32.1%(45/140),비린암29.0%(47/162)중,차이무통계학의의(χ2=0.35, P=0.556)。불동년령조환자종류조직TS고표체솔분별위:≤45세조45.2%(14/31)、46~69세조31.7%(70/221)화≥70세조16.0%(8/50),차이유통계학의의(χ2=8.52, P =0.016)。287례NSCLC환자병리유분화정도,저분화화중고분화종류조직TS고표체솔분별위37.8%(37/98)화25.4%(48/189),차이유통계학의의(χ2=4.73, P =0.030)。상관성분석현시년령여IHC득분정부상관( r =-0.15, P =0.010);분화정도여IHC득분무관( r =-0.11, P =0.057)。 NSCLC환자불동병리류형성별、흡연지수、종류대소、TNM분기화유무림파결전이간TS단백표체수평,균차이무통계학의의(χ2=0.35,0.85,0.41,0.01,0.16,0.67;P>0.05)。결론 NSCLC류조직표체TS수평고저여년령화종류분화정도상관;불동년령조환자화불동분화정도적종류조직TS표체적수평유차이,부년령여TS적표체정부상관。
Objective To explore the relationship among the thymidylate synthase ( TS) level,age and different clinicopathologic features in human non?small cell lung cancer(NSCLC) tumor tissue.Methods The clinical data and operative specimens of 302 NSCLC patients were collected in Oncology of Beijing Chest Hospital from March 2008 to October 2009. TS protein expression was evaluated by semi?quantitative immunohistochemistry (IHC) in formalin?fixed paraffin?embedded (FFPE) specimens.Patients were divided into three groups:≤45 years old group,the 46~69 age group,≥70 years old group.IHC scores range was 0~9 points.Furthermore,according to the IHC score,patients were divided into two groups:low group (0~3 points) and high group(>3 points).TS expression rates in different groups were analyzed byχ2 test and the correlation analysis was conducted by Pearson correlation analysis. Results There were 140 ( 46. 4%) squamous cell carcinoma and 162(53.6%) non?squamous cell carcinoma patients in the total 302 cases.The rate of TS high expression in squamous cell carcinoma was 32. 1% ( 45/140) while in non?squamous cell carcinoma was 29.0% (47/162) respectively,no significant difference was observed( χ2=0.35, P =0.556). TS high expression rates in different age groups were 45.2% (14/31),31.7% (70/221) and 16.0% (8/50) respectively,and the difference was statistically significant ( χ2=8.52, P =0.016) . Two hundred and eighty?seven NSCLC patients had pathologic differentiation, TS high expression rates in poorly differentiated and well?differentiated tumor tissue were 37.8%(37/98) and 25.4%(48/189) respectively,the difference was statistically obvious ( χ2=4.73, P =0.030).Correlation analysis showed that age was negatively correlated with the IHC scores( r =-0.15, P =0.010);IHC scores had no correlation with the degree of differentiation ( r =-0.11, P =0.057).No significant difference was found in TS expression among pathological type,sex, smoking index,tumor size,TNM stage and lymph node metastasis( χ2=0.35,0.85,0.41,0.01,0.16,0.16;P>0.05).Conclusion TS expression in NSCLC tumor′s tissue is relative to age as well as the degree of tumor differentiation,but it is only negatively correlated with age.