中国药业
中國藥業
중국약업
China Pharmaceuticals
2015年
21期
4-8
,共5页
戴川%赵圣轩%林世博%陈宇瑛
戴川%趙聖軒%林世博%陳宇瑛
대천%조골헌%림세박%진우영
利伐沙班%中间体%工业化路线
利伐沙班%中間體%工業化路線
리벌사반%중간체%공업화로선
rivaroxaban%intermediates%industrialization route
目的 研究利伐沙班合成工艺,提高利伐沙班的合成产率,得到适合利伐沙班工业化的合成路线.方法 通过查阅文献和专利,筛选出合成各关键中间体最优路线.结果与结论 得到一条适用于工业化合成利伐沙班的路线.该法工艺简单,易于分离,适于工业化生产.
目的 研究利伐沙班閤成工藝,提高利伐沙班的閤成產率,得到適閤利伐沙班工業化的閤成路線.方法 通過查閱文獻和專利,篩選齣閤成各關鍵中間體最優路線.結果與結論 得到一條適用于工業化閤成利伐沙班的路線.該法工藝簡單,易于分離,適于工業化生產.
목적 연구리벌사반합성공예,제고리벌사반적합성산솔,득도괄합리벌사반공업화적합성로선.방법 통과사열문헌화전리,사선출합성각관건중간체최우로선.결과여결론 득도일조괄용우공업화합성리벌사반적로선.해법공예간단,역우분리,괄우공업화생산.
Objective To study on the synthesis of rivaroxaban to increase synthesis yield of rivaroxaban and find a route of industrial-ization for the synthetic of rivaroxaban. Methods The key intermediate for synthesis by screening out the optimal route from consulting literature and patents. Results and conclusion A route for the industrial synthesis of rivaroxaban was found. The method has the ad-vantages of simple process, easy separation, and is suitable for industrialized production.
