中国药业
中國藥業
중국약업
China Pharmaceuticals
2015年
21期
92-94
,共3页
舒血宁注射液%银杏二萜内酯葡胺注射液%药理作用
舒血寧註射液%銀杏二萜內酯葡胺註射液%藥理作用
서혈저주사액%은행이첩내지포알주사액%약리작용
Shuxuening Injection%Ginkgo Diterpene Lactone Meglumine Injection%pharmacological action research
目的 比较舒血宁注射液和银杏二萜内酯葡胺注射液药理作用的区别,为临床使用提供参考.方法 选择性状相似的小鼠,给予不同剂量的舒血宁注射液和银杏二萜内酯葡胺注射液.结果 高剂量的舒血宁组和银杏二萜内酯葡胺组小鼠的单核-巨噬细胞碳粒廓清指数(K)和吞噬指数(α)均显著升高,均较对照组小鼠有显著性差异( P<0. 05),但银杏二萜内酯葡胺注射液的免疫效果更明显;高剂量的舒血宁和银杏二萜内酯葡胺注射液均显著降低小鼠的收缩压和舒张压,均较对照组具有显著性差异( P<0. 05),但银杏二萜内酯葡胺注射液的降压效果更明显;高剂量的舒血宁注射液和银杏二萜内酯葡胺注射液均能显著促进小鼠的睡眠,入睡比例和入睡时间均较对照组小鼠有显著性差异( P<0. 05),但银杏二萜内酯葡胺注射液组镇静效果更显著.结论 舒血宁注射液和银杏二萜内酯葡胺注射液均有较好的免疫、降血压、中枢镇静作用,但后者的药理活性更强.
目的 比較舒血寧註射液和銀杏二萜內酯葡胺註射液藥理作用的區彆,為臨床使用提供參攷.方法 選擇性狀相似的小鼠,給予不同劑量的舒血寧註射液和銀杏二萜內酯葡胺註射液.結果 高劑量的舒血寧組和銀杏二萜內酯葡胺組小鼠的單覈-巨噬細胞碳粒廓清指數(K)和吞噬指數(α)均顯著升高,均較對照組小鼠有顯著性差異( P<0. 05),但銀杏二萜內酯葡胺註射液的免疫效果更明顯;高劑量的舒血寧和銀杏二萜內酯葡胺註射液均顯著降低小鼠的收縮壓和舒張壓,均較對照組具有顯著性差異( P<0. 05),但銀杏二萜內酯葡胺註射液的降壓效果更明顯;高劑量的舒血寧註射液和銀杏二萜內酯葡胺註射液均能顯著促進小鼠的睡眠,入睡比例和入睡時間均較對照組小鼠有顯著性差異( P<0. 05),但銀杏二萜內酯葡胺註射液組鎮靜效果更顯著.結論 舒血寧註射液和銀杏二萜內酯葡胺註射液均有較好的免疫、降血壓、中樞鎮靜作用,但後者的藥理活性更彊.
목적 비교서혈저주사액화은행이첩내지포알주사액약리작용적구별,위림상사용제공삼고.방법 선택성상상사적소서,급여불동제량적서혈저주사액화은행이첩내지포알주사액.결과 고제량적서혈저조화은행이첩내지포알조소서적단핵-거서세포탄립곽청지수(K)화탄서지수(α)균현저승고,균교대조조소서유현저성차이( P<0. 05),단은행이첩내지포알주사액적면역효과경명현;고제량적서혈저화은행이첩내지포알주사액균현저강저소서적수축압화서장압,균교대조조구유현저성차이( P<0. 05),단은행이첩내지포알주사액적강압효과경명현;고제량적서혈저주사액화은행이첩내지포알주사액균능현저촉진소서적수면,입수비례화입수시간균교대조조소서유현저성차이( P<0. 05),단은행이첩내지포알주사액조진정효과경현저.결론 서혈저주사액화은행이첩내지포알주사액균유교호적면역、강혈압、중추진정작용,단후자적약리활성경강.
Objective To compare the different pharmacological effects of Shuxuening injection and Ginkgo diterpene lactone meglumine Injection to provide suitable clinical reference. Methods Mice with similar traits were chosen and treated with different doses of Shux-uening injection and Ginkgo Diterpene Lactone Meglumine Injection. Results The high dose of Shuxuening Injection group and Ginkgo Diterpene Lactone Meglumine Injection group were significantly increased in mice monocyte-macrophage carbon particle clearance index K and index alpha of phagocytosis, and were lower than those in the control group with significant difference ( P < 0. 05 ) , but the im-mune effects of Ginkgo Diterpene Lactone Meglumine Injection group was more obvious; high dose of Shuxuening Injection group and Ginkgo Diterpene Lactone Meglumine Injection group were significantly decreased in mice systolic and diastolic blood pressure, which were lower than those in the control group with significant difference ( P < 0. 05 ) , but the hypotensive effect of the Ginkgo Diterpene Lactone Meglumine Injection group was more obvious; high dose of Shuxuening Injection group and Ginkgo diterpene lactone meglumine Injection group were significantly accelerated in the mice's sleep, sleep time ratio, which were lower than those in the control group with significant difference ( P < 0. 05 ) , but the Ginkgo Diterpene Lactone Meglumine Injection group was more significant in the sedative ef-fect. Conclusion Shuxuening Injection and Ginkgo Diterpene Lactone Meglumine Injection both have good immune function, as well as blood pressure lowering and central sedation effect, but Ginkgo Diterpene Lactone Meglumine Injection has strong pharmacological activity.
