CAJ | 학술논문

目的考察黄体酮热熔压敏胶透皮贴剂皮肤用药的安全性.方法通过对豚鼠的皮肤急性毒性试验、皮肤过敏性试验及家兔的皮肤刺激性试验,观察黄体酮热熔胶透皮贴剂对动物经皮肤用药的急性毒性、刺激性和敏感性.结果黄体酮热熔胶透皮贴剂对豚鼠的完整皮肤和破损皮肤均未引起急性毒性反应,对家兔皮肤未产生刺激作用,对豚鼠皮肤未产生致敏作用.结论黄体酮热熔胶透皮贴剂皮肤用药安全、无毒.
목적 고찰황체동열용압민효투피첩제피부용약적안전성.방법 통과대돈서적피부급성독성시험、피부과민성시험급가토적피부자격성시험,관찰황체동열용효투피첩제대동물경피부용약적급성독성、자격성화민감성.결과 황체동열용효투피첩제대돈서적완정피부화파손피부균미인기급성독성반응,대가토피부미산생자격작용,대돈서피부미산생치민작용.결론 황체동열용효투피첩제피부용약안전、무독.
Objective To investigate the safety of progesterone hot-melt pressure sensitive adhesive transdermal patch through the skin. Methods The aim of this research was to survey acute toxicity, irritation and hypersensitivity of progesterone hot-melt adhesive transdermal patch on animal skin through skin acute toxicity, skin hypersensitivity in healthy guinea pigs, and skin irritation test in healthy rabbits. Results The result showed that the progesterone hot-melt adhesive transdermal patch had no acute toxicity on inte-grated and worn skin of guinea pigs, it had no irritation on integrated and worn skin of rabbits, and it had no hypersensitivity on skin of guinea pigs. Conclusion The experiment indicated that it is safe to administrate the progesterone hot-melt adhesive transdermal patch via skin.