中国药业
中國藥業
중국약업
China Pharmaceuticals
2015年
21期
58-59,54
,共3页
王宇%李文军%郭军%饶友义
王宇%李文軍%郭軍%饒友義
왕우%리문군%곽군%요우의
利伐沙班%出血%不良反应信号%数据挖掘
利伐沙班%齣血%不良反應信號%數據挖掘
리벌사반%출혈%불량반응신호%수거알굴
rivaroxaban%bleeding%signals of ADR%data mining
目的 通过探讨利伐沙班引起的不良反应信号,为临床合理用药提供参考.方法 采用报告比值比(ROR)法对美国不良事件报告系统(AERS)2013年第1季度至第3季度收集的报告进行分析,找出利伐沙班致各部位出血的相关信号.结果 共挖掘出利伐沙班致各部位出血的可疑不良反应危险信号70个,其中部分为药品说明书尚未提及的新不良反应.结论 挖掘出利伐沙班致各部位出血的不良反应相关信号,可为其在临床合理用药使用提供依据.
目的 通過探討利伐沙班引起的不良反應信號,為臨床閤理用藥提供參攷.方法 採用報告比值比(ROR)法對美國不良事件報告繫統(AERS)2013年第1季度至第3季度收集的報告進行分析,找齣利伐沙班緻各部位齣血的相關信號.結果 共挖掘齣利伐沙班緻各部位齣血的可疑不良反應危險信號70箇,其中部分為藥品說明書尚未提及的新不良反應.結論 挖掘齣利伐沙班緻各部位齣血的不良反應相關信號,可為其在臨床閤理用藥使用提供依據.
목적 통과탐토리벌사반인기적불량반응신호,위림상합리용약제공삼고.방법 채용보고비치비(ROR)법대미국불량사건보고계통(AERS)2013년제1계도지제3계도수집적보고진행분석,조출리벌사반치각부위출혈적상관신호.결과 공알굴출리벌사반치각부위출혈적가의불량반응위험신호70개,기중부분위약품설명서상미제급적신불량반응.결론 알굴출리벌사반치각부위출혈적불량반응상관신호,가위기재림상합리용약사용제공의거.
Objective To mine the ADR signals induced by rivaroxaban, and to provide references for clinical rational drug use. Methods Report odds ratio method was used to mine the signals from the ADR reports of Adverse Event Reporting System for the United States from first quarter to third quarter in 2013, the signals of bleeding in various parts causing by rivaroxaban were discovered. Results 70 warning signals of bleeding in various parts causing by rivaroxaban were obtained,some of which were the new adverse reactions that are not mentioned by the instructions. Conclusion Mining the ADR signals of bleeding in various parts induced by rivaroxaban can provide references for clinical rational drug use.
