CAJ | 학술논문

目的探讨莫西沙星治疗耐多药肺结核的临床疗效及对患者血清降钙素原(PCT)与C反应蛋白(CRP)水平的影响.方法选取医院收治的耐多药肺结核患者92例,按患者治疗意愿分为试验组和对照组,各46例.试验组患者采用莫西沙星联合常规化学治疗(简称化疗) ,对照组患者采用左氧氟沙星联合常规化疗.结果治疗后,试验组患者血清PCT及CRP水平明显低于对照组( P<0. 05);试验组患者疗效明显优于对照组( P<0. 05),细胞免疫功能和体液免疫功能显著优于对照组( P<0. 05);两组患者的肝功能与治疗前相比明显改善,但组间无显著差异( P>0. 05).结论莫西沙星治疗耐多药肺结核能有效杀灭结核杆菌,降低血清PCT及CRP水平,提高机体免疫功能,同时不会加重肝脏负担,疗效显著,值得临床推广.
목적 탐토막서사성치료내다약폐결핵적림상료효급대환자혈청강개소원(PCT)여C반응단백(CRP)수평적영향.방법 선취의원수치적내다약폐결핵환자92례,안환자치료의원분위시험조화대조조,각46례.시험조환자채용막서사성연합상규화학치료(간칭화료) ,대조조환자채용좌양불사성연합상규화료.결과 치료후,시험조환자혈청PCT급CRP수평명현저우대조조( P<0. 05);시험조환자료효명현우우대조조( P<0. 05),세포면역공능화체액면역공능현저우우대조조( P<0. 05);량조환자적간공능여치료전상비명현개선,단조간무현저차이( P>0. 05).결론 막서사성치료내다약폐결핵능유효살멸결핵간균,강저혈청PCT급CRP수평,제고궤체면역공능,동시불회가중간장부담,료효현저,치득림상추엄.
Objective To analyze the effect of the treatment of serum PCT, CRP with moxifloxacin in the treatment of multi-drug resis-tant pulmonary tuberculosis. Methods 92 patients with multi drug resistant pulmonary tuberculosis were selected divided into experi-mental group ( 46 cases ) and control group ( 46 cases ) according to the different treatment. The experimental group was treated with moxifloxacin combined with conventional chemotherapy. The control group was treated with levofloxacin combined with conventional chemotherapy. Results After treatment, the serum levels of CRP and PCT in the experimental group were significantly lower than those in the control group( P < 0. 05). The effect of the experimental group was better than that of the control group( P < 0. 05). The cellu-lar immune function and humoral immunity function of the patients in the experimental group were significantly better than those in the control group( P < 0. 05). The liver function of the two groups was significantly improved compared with that before treatment( P < 0. 05). But there was no significant difference between the two groups( P > 0. 05). Conclusion Moxifloxacin in treating multi-drug resistant pulmonary tuberculosis can effectively kill mycobacterium tuberculosis, reduce serum PCT, CRP level, Improve immune function. At the same time, it will not increase the burden of the liver, the curative effect is remarkable, which is worthy of clinical promotion.