中国实用医药
中國實用醫藥
중국실용의약
China Practical Medical
2015年
35期
7-9
,共3页
亚低温治疗%脑出血%血肿抽吸术
亞低溫治療%腦齣血%血腫抽吸術
아저온치료%뇌출혈%혈종추흡술
Mild hypothermia therapy%Intracerebral hemorrhage%Hematoma aspiration
目的 探讨亚低温治疗在脑出血血肿抽吸术后治疗的临床疗效和安全性.方法 202例脑出血行血肿抽吸术治疗的患者, 随机分为观察组(102例)和对照组(100例), 术后分别予以常规内科治疗和亚低温治疗, 纪录两组治疗前后血清神经元特异性烯醇化酶(NSE)、超敏C反应蛋白(hs-CRP)水平, 比较美国国立卫生研究院卒中量表(NIHSS)评分和Barthel指数.结果 两组治疗前及治疗后3、7 d NSE水平比较差异无统计学意义(P>0.05), 表现为逐渐升高趋势, 而治疗后14 d NSE下降, 观察组下降幅度较对照组大, 差异有统计学意义(P<0.05);两组治疗前hs-CRP水平比较差异无统计学意义(P>0.05), 治疗后表现为先升后降, 观察组峰值提前, 下降也提前于对照组, 差异有统计学意义(P<0.05);两组治疗前及治疗后3、7 d NIHSS评分比较差异无统计学意义(P>0.05), 而治疗后14 d观察组显著低于对照组, 差异有统计学意义(P<0.05);随访3个月后观察组患者Barthel指数平均(71.34±23.15)分, 显著高于对照组(57.54±22.67)分, 差异有统计学意义(P<0.05).结论 亚低温治疗配合血肿抽吸术给患者带来更好的预后, 值得推广使用.
目的 探討亞低溫治療在腦齣血血腫抽吸術後治療的臨床療效和安全性.方法 202例腦齣血行血腫抽吸術治療的患者, 隨機分為觀察組(102例)和對照組(100例), 術後分彆予以常規內科治療和亞低溫治療, 紀錄兩組治療前後血清神經元特異性烯醇化酶(NSE)、超敏C反應蛋白(hs-CRP)水平, 比較美國國立衛生研究院卒中量錶(NIHSS)評分和Barthel指數.結果 兩組治療前及治療後3、7 d NSE水平比較差異無統計學意義(P>0.05), 錶現為逐漸升高趨勢, 而治療後14 d NSE下降, 觀察組下降幅度較對照組大, 差異有統計學意義(P<0.05);兩組治療前hs-CRP水平比較差異無統計學意義(P>0.05), 治療後錶現為先升後降, 觀察組峰值提前, 下降也提前于對照組, 差異有統計學意義(P<0.05);兩組治療前及治療後3、7 d NIHSS評分比較差異無統計學意義(P>0.05), 而治療後14 d觀察組顯著低于對照組, 差異有統計學意義(P<0.05);隨訪3箇月後觀察組患者Barthel指數平均(71.34±23.15)分, 顯著高于對照組(57.54±22.67)分, 差異有統計學意義(P<0.05).結論 亞低溫治療配閤血腫抽吸術給患者帶來更好的預後, 值得推廣使用.
목적 탐토아저온치료재뇌출혈혈종추흡술후치료적림상료효화안전성.방법 202례뇌출혈행혈종추흡술치료적환자, 수궤분위관찰조(102례)화대조조(100례), 술후분별여이상규내과치료화아저온치료, 기록량조치료전후혈청신경원특이성희순화매(NSE)、초민C반응단백(hs-CRP)수평, 비교미국국립위생연구원졸중량표(NIHSS)평분화Barthel지수.결과 량조치료전급치료후3、7 d NSE수평비교차이무통계학의의(P>0.05), 표현위축점승고추세, 이치료후14 d NSE하강, 관찰조하강폭도교대조조대, 차이유통계학의의(P<0.05);량조치료전hs-CRP수평비교차이무통계학의의(P>0.05), 치료후표현위선승후강, 관찰조봉치제전, 하강야제전우대조조, 차이유통계학의의(P<0.05);량조치료전급치료후3、7 d NIHSS평분비교차이무통계학의의(P>0.05), 이치료후14 d관찰조현저저우대조조, 차이유통계학의의(P<0.05);수방3개월후관찰조환자Barthel지수평균(71.34±23.15)분, 현저고우대조조(57.54±22.67)분, 차이유통계학의의(P<0.05).결론 아저온치료배합혈종추흡술급환자대래경호적예후, 치득추엄사용.
Objective To investigate clinical effect and safety of mild hypothermia therapy after hematoma aspiration for intracerebral hemorrhage.Methods A total of 202 intracerebral hemorrhage patients receiving hematoma aspiration were randomly divided into observation group (102 cases) and control group (100 cases). The two groups respectively received conventional medical treatment and mild hypothermia therapy. Records were made on their serum neuron specific enolase (NSE) and high-sensitivity C-reactive protein (hs-CRP) levels before and after treamtent. Their national institutes of health stroke scale (NIHSS) scores and Barthel indexes were compared.Results There was no statistically significant difference of NSE levels between the two groups before and in 3 and 7 d after treatment (P>0.05), with an increasing trend. While they had decreased NSE in 14 d after treatment, and the observation group had larger decrease than the control group. Their difference had statistical significance (P<0.05). Before treatment, the difference of hs-CRP levels had no statistical significance between the two groups (P>0.05). Their manifestations after treatment showed increasing trend followed by decreased trend. The observation group had earlier peak value and decrease time than the control group, and their difference had statistical significance (P<0.05). There was no statistically significant difference of NIHSS scores between the two groups before and in 3 and 7 d after treatment (P>0.05). In 14 d after treatment, the observation group had much lower NIHSS score than the control group, and the difference had statistical significance (P<0.05). After 3-month follow-up, the observation group had obviously higher average Barthel index as (71.34±23.15) points than (57.54±22.67) points of the control group. Their difference had statistical significance (P<0.05). Conclusion Mild hypothermia therapy in coordination with hematoma aspiration can bring good prognosis for patients, and this method is worth promoting and applying.