目的 提高对链球菌感染及其相关疾病的认识.方法 回顾性分析756例链球菌感染患儿的临床特点, 尤其是除急性肾小球肾炎及风湿热以外的各系统疾病情况.结果 756例患儿中, 发现急性肾小球肾炎60例(7.9%), 风湿热6例(0.8%), IgA肾病6例(0.8%), 过敏性紫癜145例(19.2%), 特发性血小板减少性紫癜12例(1.6%), 肾病综合征4例(0.5%), 川崎病2例(0.3%), 系统性红斑狼疮5例(0.7%), 硬皮病1例(0.1%), 肺含铁血黄素沉积症1例(0.1%), 心肌炎6例(0.8%), 心律失常13例(1.7%), 关节炎20例(2.6%), 癫痫症2例(0.3%), 脑血管病2例(0.3%), 急性脊髓炎2例(0.3%), 情绪障碍4例(0.5%), 急性小脑共济失调1例(0.1%), 神经系统脱髓鞘疾病2例(0.3%), 面神经炎1例(0.1%), 中毒性脑病61例(8.1%), 皮肤病7例(0.9%), 骨髓炎1例(0.1%), 化脓性脑膜炎37例(4.9%), 上呼吸道感染100例(13.2%), 下呼吸道感染255例(33.7%).各疾病抗O比较差异有统计学意义(χ2=44.472,P<0.001), 其中肾脏疾病最高, 关节炎次之.抗O与C反应蛋白(CRP)、血沉(ESR)呈正相关(r=0.083、0.116,P<0.05), 抗O与C3呈负相关(r=-0.259,P<0.05).结论 链球菌感染发病年龄以学龄期及青春期小儿为主, 与多种疾病关系密切, 需积极抗链球菌治疗才能达到较好的疗效.
目的 提高對鏈毬菌感染及其相關疾病的認識.方法 迴顧性分析756例鏈毬菌感染患兒的臨床特點, 尤其是除急性腎小毬腎炎及風濕熱以外的各繫統疾病情況.結果 756例患兒中, 髮現急性腎小毬腎炎60例(7.9%), 風濕熱6例(0.8%), IgA腎病6例(0.8%), 過敏性紫癜145例(19.2%), 特髮性血小闆減少性紫癜12例(1.6%), 腎病綜閤徵4例(0.5%), 川崎病2例(0.3%), 繫統性紅斑狼瘡5例(0.7%), 硬皮病1例(0.1%), 肺含鐵血黃素沉積癥1例(0.1%), 心肌炎6例(0.8%), 心律失常13例(1.7%), 關節炎20例(2.6%), 癲癇癥2例(0.3%), 腦血管病2例(0.3%), 急性脊髓炎2例(0.3%), 情緒障礙4例(0.5%), 急性小腦共濟失調1例(0.1%), 神經繫統脫髓鞘疾病2例(0.3%), 麵神經炎1例(0.1%), 中毒性腦病61例(8.1%), 皮膚病7例(0.9%), 骨髓炎1例(0.1%), 化膿性腦膜炎37例(4.9%), 上呼吸道感染100例(13.2%), 下呼吸道感染255例(33.7%).各疾病抗O比較差異有統計學意義(χ2=44.472,P<0.001), 其中腎髒疾病最高, 關節炎次之.抗O與C反應蛋白(CRP)、血沉(ESR)呈正相關(r=0.083、0.116,P<0.05), 抗O與C3呈負相關(r=-0.259,P<0.05).結論 鏈毬菌感染髮病年齡以學齡期及青春期小兒為主, 與多種疾病關繫密切, 需積極抗鏈毬菌治療纔能達到較好的療效.
목적 제고대련구균감염급기상관질병적인식.방법 회고성분석756례련구균감염환인적림상특점, 우기시제급성신소구신염급풍습열이외적각계통질병정황.결과 756례환인중, 발현급성신소구신염60례(7.9%), 풍습열6례(0.8%), IgA신병6례(0.8%), 과민성자전145례(19.2%), 특발성혈소판감소성자전12례(1.6%), 신병종합정4례(0.5%), 천기병2례(0.3%), 계통성홍반랑창5례(0.7%), 경피병1례(0.1%), 폐함철혈황소침적증1례(0.1%), 심기염6례(0.8%), 심률실상13례(1.7%), 관절염20례(2.6%), 전간증2례(0.3%), 뇌혈관병2례(0.3%), 급성척수염2례(0.3%), 정서장애4례(0.5%), 급성소뇌공제실조1례(0.1%), 신경계통탈수초질병2례(0.3%), 면신경염1례(0.1%), 중독성뇌병61례(8.1%), 피부병7례(0.9%), 골수염1례(0.1%), 화농성뇌막염37례(4.9%), 상호흡도감염100례(13.2%), 하호흡도감염255례(33.7%).각질병항O비교차이유통계학의의(χ2=44.472,P<0.001), 기중신장질병최고, 관절염차지.항O여C반응단백(CRP)、혈침(ESR)정정상관(r=0.083、0.116,P<0.05), 항O여C3정부상관(r=-0.259,P<0.05).결론 련구균감염발병년령이학령기급청춘기소인위주, 여다충질병관계밀절, 수적겁항련구균치료재능체도교호적료효.
Objective To improve understanding of streptococcal infection and its related diseases. Methods A retrospective analysis was made on clinical characteristics, especially condition of organ and system diseases with the exception of acute glomerulonephritis and rheumatic fever, in 756 children with streptococcal infection.Results Among 756 children patients, there were 60 cases with acute glomerulonephritis (7.9%), 6 cases with rheumatic fever (0.8%), 6 cases with IgA nephropathy (0.8%), 145 cases with anaphylactoid purpura (19.2%), 12 cases with idiopathic thrombocytopenic purpura (1.6%), 4 cases with nephrotic syndrome (0.5%), 2 cases with Kawasaki disease (0.3%), 5 cases with systemic lupus erythematosus (0.7%), 1 case with scleroderma (0.1%), 1 case with pulmonary hemosiderosis (0.1%), 6 cases with myocarditis (0.8%), 13 cases with arrhythmia (1.7%), 20 cases with arthritis (2.6%), 2 cases with epilepsy (0.3%), 2 cases with cerebrovascular disease (0.3%), 2 cases with acute myelitis (0.3%), 4 cases with emotional disorder (0.5%), 1 case with acute cerebellar ataxia (0.1%), 2 cases with neurologic demyelinating diseases (0.3%), 1 case with facial neuritis (0.1%), 61 cases with toxic encephalopathy (8.1%), 7 cases with dermatosis (0.9%), 1 case with osteomyelitis (0.1%), 37 cases with suppurative meningitis (4.9%), 100 cases with upper respiratory infection (13.2%), and 255 cases with lower respiratory infection (33.7%). The difference of anti-O in each diseases had statistical significance (χ2=44.472, P<0.001), and nephropathy had the highest level, followed by arthritis. Anti-O was positively correlated with C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) (r=0.083, 0.116,P<0.05), and it had negative correlation with C3 (r=-0.259,P<0.05).Conclusion Main onset age of streptococcal infection includes school-age and adolescence. This disease is closely related with multiple diseases, and active antistreptococcic treatment is essential for good curative effect.
