山西医药杂志
山西醫藥雜誌
산서의약잡지
Shanxi Medical Journal
2015年
22期
2609-2611
,共3页
结肠炎,溃疡性%生物学标记%血液
結腸炎,潰瘍性%生物學標記%血液
결장염,궤양성%생물학표기%혈액
Colitis%ulcerative%Biological markers%Blood
目的 探讨常见血液检测指标对溃疡性结肠炎(U C )的诊断、疾病严重程度及相关性的价值.方法 回顾性分析2009年8月至2014年8月中国医科大学附属盛京医院消化科收治的108例U C患者及55名健康对照者的临床资料及检测血常规、肝功能、凝血及红细胞沉降率(ESR)的结果.结果 活动期 UC患者的血红蛋白(Hb)、平均血小板体积(MPV)、血清白蛋白(ALB)水平显著低于对照组及缓解期UC患者 ,而血小板计数(PLT)、红细胞分布宽度(RDW)、D-二聚体、纤维蛋白原(FIB)、ESR的水平显著高于对照组及缓解期UC患者(P<0.05);重度活动UC患者的 Hb、MPV、ALB显著低于中度及轻度活动组 ;PLT、D-二聚体、FIB、ESR、RDW显著高于轻度及中度活动组(P<0.05).各指标在UC患者的活动性均不十分理想 ,但ESR、RDW、MPV三者联合检测的受试者工作特征曲线(ROC)曲线下面积为0 .891;Hb、MPV和ALB与 UC患者严重程度呈负相关(P<0.05) ,PLT、RDW、D-二聚体、FIB、ESR与UC患者严重程度呈正相关.结论 常见血液各指标检查简单易行 ,可作为初筛指标 ,可以帮助早发现UC患者、早完善其他相关检查、尽早地开展个体化的治疗.
目的 探討常見血液檢測指標對潰瘍性結腸炎(U C )的診斷、疾病嚴重程度及相關性的價值.方法 迴顧性分析2009年8月至2014年8月中國醫科大學附屬盛京醫院消化科收治的108例U C患者及55名健康對照者的臨床資料及檢測血常規、肝功能、凝血及紅細胞沉降率(ESR)的結果.結果 活動期 UC患者的血紅蛋白(Hb)、平均血小闆體積(MPV)、血清白蛋白(ALB)水平顯著低于對照組及緩解期UC患者 ,而血小闆計數(PLT)、紅細胞分佈寬度(RDW)、D-二聚體、纖維蛋白原(FIB)、ESR的水平顯著高于對照組及緩解期UC患者(P<0.05);重度活動UC患者的 Hb、MPV、ALB顯著低于中度及輕度活動組 ;PLT、D-二聚體、FIB、ESR、RDW顯著高于輕度及中度活動組(P<0.05).各指標在UC患者的活動性均不十分理想 ,但ESR、RDW、MPV三者聯閤檢測的受試者工作特徵麯線(ROC)麯線下麵積為0 .891;Hb、MPV和ALB與 UC患者嚴重程度呈負相關(P<0.05) ,PLT、RDW、D-二聚體、FIB、ESR與UC患者嚴重程度呈正相關.結論 常見血液各指標檢查簡單易行 ,可作為初篩指標 ,可以幫助早髮現UC患者、早完善其他相關檢查、儘早地開展箇體化的治療.
목적 탐토상견혈액검측지표대궤양성결장염(U C )적진단、질병엄중정도급상관성적개치.방법 회고성분석2009년8월지2014년8월중국의과대학부속성경의원소화과수치적108례U C환자급55명건강대조자적림상자료급검측혈상규、간공능、응혈급홍세포침강솔(ESR)적결과.결과 활동기 UC환자적혈홍단백(Hb)、평균혈소판체적(MPV)、혈청백단백(ALB)수평현저저우대조조급완해기UC환자 ,이혈소판계수(PLT)、홍세포분포관도(RDW)、D-이취체、섬유단백원(FIB)、ESR적수평현저고우대조조급완해기UC환자(P<0.05);중도활동UC환자적 Hb、MPV、ALB현저저우중도급경도활동조 ;PLT、D-이취체、FIB、ESR、RDW현저고우경도급중도활동조(P<0.05).각지표재UC환자적활동성균불십분이상 ,단ESR、RDW、MPV삼자연합검측적수시자공작특정곡선(ROC)곡선하면적위0 .891;Hb、MPV화ALB여 UC환자엄중정도정부상관(P<0.05) ,PLT、RDW、D-이취체、FIB、ESR여UC환자엄중정도정정상관.결론 상견혈액각지표검사간단역행 ,가작위초사지표 ,가이방조조발현UC환자、조완선기타상관검사、진조지개전개체화적치료.
Objective To investigate the diagnostic value of common blood parameters in activity and severi-ty assessment of ulcerative colitis(UC) ,and their correlation .Methods From August 2009 to August 2014 ,108 cases of UC patients and 55 healthy controls were retrospectively analyzed the clinical data ,blood routine test ,liv-er function ,blood coagulation and red blood cell sedimentation rate (ESR) in Shengjing Hospital affiliated to Chi-na Medical University .Results The level of hemoglobin (Hb) ,mean platelet volume (MPV) ,serum albumin (ALB) in active UC patients were significantly lower than those in the control group and the UC patients in remis-sion .The platelet count (PLT) ,red cell distribution width (RDW) ,D-dimer ,fibrinogen (FIB) and the level of ESR were significantly higher than those of the control group and the UC patients in remission (P<0.05);the levels of Hb ,MPV and ALB in severe UC patients were significantly lower than those in moderate and mild group;PLT ,D-dimer ,FIB ,ESR and RDW in severe UC patients were significantly higher than those of mild and moderate active group (P<0 .05) .Each index in patients with UC are not very ideal ,but the ROC of the combi-nation detection of ESR ,RDW and MPV were 0 .891 .Hb ,MPV and ALB were negative correlated with severity of UC patients(P<0 .05) ,PLT ,RDW ,D-dimer ,FIB and ESR were positively correlated with severity of UC pa-tients(P<0 .05) .Conclusion Common blood parameters test is simple and easy ,can be used as a screening in-dex ,can help early detection of patients with UC ,as early as the other related to improve the examination ,as soon as possible to carry out individual treatment .
