CAJ | 학술논문

目的探讨新生儿败血症与绒毛膜羊膜炎的相关性及美罗培南治疗的临床疗效.方法将2014年4月至12月收治的150例新生儿败血症患儿分为研究组和对照组,各75例.对照组采用常规抗感染治疗措施,研究组采用美罗培南治疗.结果 150例新生儿败血症患儿中合并120例绒毛膜羊膜炎,发生率为80. 00%,为新生儿败血症的重要致病因素.两组患儿在治疗前后急性生理学及慢性健康状态评分系统( APACHEⅡ评分)和全身性感染相关衰竭评分( SOFA评分)之间的差异均有统计学意义( P<0. 05),两种治疗方式均能改善患儿各项指标( P<0. 05),且研究组改善情况优于对照组( P<0. 05).治疗前两组患儿的C反应蛋白( CRP ) ,降钙素原( PCT ) ,CD64值差异无统计学意义( P>0. 05),治疗后两组患儿较治疗前均显著降低( P<0. 05),研究组好转更显著( P<0. 05).研究组临床总有效率为86. 67%,高于对照组患儿的60. 00%( P<0. 05).结论绒毛膜羊膜炎是新生儿败血症发病的重要因素.美罗培南治疗新生儿败血症具有显著临床疗效,能减轻患儿机体的炎症反应,阻止病情恶化,促进机体康复.
목적 탐토신생인패혈증여융모막양막염적상관성급미라배남치료적림상료효.방법 장2014년4월지12월수치적150례신생인패혈증환인분위연구조화대조조,각75례.대조조채용상규항감염치료조시,연구조채용미라배남치료.결과 150례신생인패혈증환인중합병120례융모막양막염,발생솔위80. 00%,위신생인패혈증적중요치병인소.량조환인재치료전후급성생이학급만성건강상태평분계통( APACHEⅡ평분)화전신성감염상관쇠갈평분( SOFA평분)지간적차이균유통계학의의( P<0. 05),량충치료방식균능개선환인각항지표( P<0. 05),차연구조개선정황우우대조조( P<0. 05).치료전량조환인적C반응단백( CRP ) ,강개소원( PCT ) ,CD64치차이무통계학의의( P>0. 05),치료후량조환인교치료전균현저강저( P<0. 05),연구조호전경현저( P<0. 05).연구조림상총유효솔위86. 67%,고우대조조환인적60. 00%( P<0. 05).결론 융모막양막염시신생인패혈증발병적중요인소.미라배남치료신생인패혈증구유현저림상료효,능감경환인궤체적염증반응,조지병정악화,촉진궤체강복.
Objective To study the correlation between neonatal septicemia and chorioamnionitis and the Safety of meropenem. Methods 150 cases of neonatal septicemia admitted to the hospital from April to December 2014 was divided into the study group ( 75 cas-es ) and control group ( 75 cases ) . The control group was treated with conventional anti-infection treatment, and the study group re-ceived meropenem. Results 120 cases out of 150 cases of neonatal sepsis were with chorioamnionitis, the rate was 80. 00%, forming an important pathogenic factor in neonatal septicemia. APACHEⅡscores and SOFA scores of the two groups before and after treatment had statistically significant difference ( P < 0. 05 ) , indicators in both groups improved; the two indicators after treatment between the two group had statistically significant difference, and the study group improved more ( P < 0. 05 ) . Before treatment, the patient's CRP, PCT, CD64 value difference was not statistically significant ( P > 0. 05 ) , after treatment, compared two groups of patients before treatment were significantly lower ( P < 0. 05 ) , the study group improved more significantly than the control group ( P < 0. 05 ) . Study group received 2 courses of treatment, and the clinical total effective rate was 86. 67%, which was higher than 60. 00% of the control group, and the difference was statistically significant ( P < 0. 05 ) . Conclusion Chorioamnionitis is an important factor in the pathogenesis of neonatal sepsis; in the treatment of neonatal sepsis meropenem has significant clinical efficacy, can reduce the body's inflammatory response to prevent disease progression, and promote the body's recovery.