新疆医学
新疆醫學
신강의학
Xinjiang Medical Journal
2015年
11期
1648-1650,1637
,共4页
王平%旷南岳%李文军%李辉
王平%曠南嶽%李文軍%李輝
왕평%광남악%리문군%리휘
美罗培南%输注方式%重症肺炎
美囉培南%輸註方式%重癥肺炎
미라배남%수주방식%중증폐염
meropenem%infusion methods%severe pneumonia
目的 观察美罗培南不同输注方式治疗重症肺炎的临床疗效.方法 选取ICU重症肺炎患者40例,随机分为两组:对照组和治疗组.对照组的输注方案为美罗培南1g溶于0.9%的生理盐水100mL中,经30min静脉点滴给药;治疗组的输注方案为美罗培南1g溶于0.9%的生理盐水50 ml中,微量推注泵持续3h泵入.比较两组患者的体温和白细胞变化值、临床疗效、病原学疗效及不良反应发生率等相关指标.结果 给药72h后,白细胞计数变化值两组间比较无统计学意义(P>0.05);体温下降幅度治疗组高于对照组(P<0.05).停药当天,治疗组临床有效率及细菌清除率高于对照组P<0.05.结论 美罗培南3h持续泵入给药方案治疗重症肺炎的疗效优于30min静脉点滴给药.
目的 觀察美囉培南不同輸註方式治療重癥肺炎的臨床療效.方法 選取ICU重癥肺炎患者40例,隨機分為兩組:對照組和治療組.對照組的輸註方案為美囉培南1g溶于0.9%的生理鹽水100mL中,經30min靜脈點滴給藥;治療組的輸註方案為美囉培南1g溶于0.9%的生理鹽水50 ml中,微量推註泵持續3h泵入.比較兩組患者的體溫和白細胞變化值、臨床療效、病原學療效及不良反應髮生率等相關指標.結果 給藥72h後,白細胞計數變化值兩組間比較無統計學意義(P>0.05);體溫下降幅度治療組高于對照組(P<0.05).停藥噹天,治療組臨床有效率及細菌清除率高于對照組P<0.05.結論 美囉培南3h持續泵入給藥方案治療重癥肺炎的療效優于30min靜脈點滴給藥.
목적 관찰미라배남불동수주방식치료중증폐염적림상료효.방법 선취ICU중증폐염환자40례,수궤분위량조:대조조화치료조.대조조적수주방안위미라배남1g용우0.9%적생리염수100mL중,경30min정맥점적급약;치료조적수주방안위미라배남1g용우0.9%적생리염수50 ml중,미량추주빙지속3h빙입.비교량조환자적체온화백세포변화치、림상료효、병원학료효급불량반응발생솔등상관지표.결과 급약72h후,백세포계수변화치량조간비교무통계학의의(P>0.05);체온하강폭도치료조고우대조조(P<0.05).정약당천,치료조림상유효솔급세균청제솔고우대조조P<0.05.결론 미라배남3h지속빙입급약방안치료중증폐염적료효우우30min정맥점적급약.
Objective To investigate the efficacy of different infusion methods of meropenem in the treatment of severe pneumonia. Methods 40 cases of patients with severe pneumonia form ICU, were randomly divided into treatment group and control group. In the control group, meropenem 1g was added into 100mL NS intravenous infusion for 30 minutes, every 8 hours at a time.In the treatment group, meropenem 1g was added into 50mL NS using micro pump intravenously for 3 hours, every 8 hours at a time.Other treatment were expectorant, life support and nutritional support and other symptomatic treatment. At last, the changes of body temperature and white blood cell count;the bacterial clearance rate;the incidence of adverse reactions and another indicators of the two groups were compared. Results After 72 hours of meropenem administration, no significant difference was obeserved on white blood cell counts of the two groups (P>0.05);compared with control group, the temperature in treatment group significantly dereased (P<0.05); On the withdrawal day, the clinical efficiency and bacterial clearance rate were treatment group than control group (P<0.05). Conclusion Meropenem in the way of 3 hour infusion on severe pneumonia's treatment has better efficacy than that of 30 minutes infusion.
