中国综合临床
中國綜閤臨床
중국종합림상
Clinical Medicine of China
2015年
12期
1145-1148
,共4页
胰岛素样生长因子1%多发性抽动症%S100B蛋白%ROC曲线
胰島素樣生長因子1%多髮性抽動癥%S100B蛋白%ROC麯線
이도소양생장인자1%다발성추동증%S100B단백%ROC곡선
Insulin-like growth factor 1%Children with tourette syndrome%S100B protein%Receiver operating characteristic curve
目的 研究多发性抽动症患儿血清胰岛素样生长因子1(IGF-1)水平及其在多发性抽动症诊断中的作用.方法 用ELISA检测53例多发性抽动症和53名健康体检者血清中IGF-1和S100B水平,绘制ROC曲线确定其诊断多发性抽动症的临界值,并评价其敏感性、特异性和诊断效能.结果 多发性抽动症组IGF-1含量显著低于正常对照组[(41.51±4.23) μg/L与(69.04±5.26) μg/L,t=29.693,P＜0.01];S100B水平显著高于正常对照组[(129.48±9.54) ng/L与(81.37±8.42)ng/L,t=27.526,P＜0.01].IGF-1和S100B诊断多发性抽动症的临界值分别为59.28 μg/L、93.35 ng/L,敏感性为89.6％、94.1％,特异性为96.4％、91.3％,ROC曲线下面积为0.931、0.969.结论 IGF-1可能与儿童多发性抽动症发生有关,IGF-1的诊断效能与S100B相近,且血清IGF-1水平测定有助于多发性抽动症的诊断.
目的 研究多髮性抽動癥患兒血清胰島素樣生長因子1(IGF-1)水平及其在多髮性抽動癥診斷中的作用.方法 用ELISA檢測53例多髮性抽動癥和53名健康體檢者血清中IGF-1和S100B水平,繪製ROC麯線確定其診斷多髮性抽動癥的臨界值,併評價其敏感性、特異性和診斷效能.結果 多髮性抽動癥組IGF-1含量顯著低于正常對照組[(41.51±4.23) μg/L與(69.04±5.26) μg/L,t=29.693,P＜0.01];S100B水平顯著高于正常對照組[(129.48±9.54) ng/L與(81.37±8.42)ng/L,t=27.526,P＜0.01].IGF-1和S100B診斷多髮性抽動癥的臨界值分彆為59.28 μg/L、93.35 ng/L,敏感性為89.6％、94.1％,特異性為96.4％、91.3％,ROC麯線下麵積為0.931、0.969.結論 IGF-1可能與兒童多髮性抽動癥髮生有關,IGF-1的診斷效能與S100B相近,且血清IGF-1水平測定有助于多髮性抽動癥的診斷.
목적 연구다발성추동증환인혈청이도소양생장인자1(IGF-1)수평급기재다발성추동증진단중적작용.방법 용ELISA검측53례다발성추동증화53명건강체검자혈청중IGF-1화S100B수평,회제ROC곡선학정기진단다발성추동증적림계치,병평개기민감성、특이성화진단효능.결과 다발성추동증조IGF-1함량현저저우정상대조조[(41.51±4.23) μg/L여(69.04±5.26) μg/L,t=29.693,P＜0.01];S100B수평현저고우정상대조조[(129.48±9.54) ng/L여(81.37±8.42)ng/L,t=27.526,P＜0.01].IGF-1화S100B진단다발성추동증적림계치분별위59.28 μg/L、93.35 ng/L,민감성위89.6％、94.1％,특이성위96.4％、91.3％,ROC곡선하면적위0.931、0.969.결론 IGF-1가능여인동다발성추동증발생유관,IGF-1적진단효능여S100B상근,차혈청IGF-1수평측정유조우다발성추동증적진단.
Objective To explore the relationships between serum insulin-like growth factor 1 (IGF-1) level and children with tourette syndrome, and the significance of IGF-1 level for the diagnosis of tourette syndrome.Methods Enzyme-linked immunosorbent assay (ELISA) was adopted to detect the serum level of IGF-1 and S100B of 53 children patients with tourette syndrome and 53 children with physical examination.The receiver operating characteristic (ROC) curves were used to determine the cut-off value and assess the sensitivity,specificity and diagnostic efficiency.Results The concentration of IGF-1 was significantly lower in the children with tourette syndrome group than in normal group ((41.51±4.23) μg/L vs.(69.04±5.26) μg/ L,t=29.693,P＜0.01),and the concentration of S100B was significantly higher in the children with tourette syndrome group than in normal group((129.48±9.54) ng/L vs.(81.37±8.42) ng/L,t =27.526,P＜0.01) .When 59.28 and 93.35 ng/mL ware used as cut-off value, the sensitivity, specificity and area under curve for IGF-1 in diagnosis of children with tourette syndrome were 89.6％, 96.4％ and 0.931, respectively.The sensitivity,specificity and area under curve for S100B in diagnosis of children with tourette syndrome were 94.1％, 91.3％ and 0.969, respectively.And the diagnostic efficiency of IGF-1 was similar to that of S100B.Conclusion IGF-1 may play an important role in the development of tourette syndrome.Detection of IGF-1 in the serum is helpful in the diagnosis of children with tourette syndrome.
