中国实用医刊
中國實用醫刊
중국실용의간
Chinese Journal of Practical Medicine
2015年
24期
73-75
,共3页
急性缺血性脑卒中%阿替普酶%用药剂量%神经功能%病死率
急性缺血性腦卒中%阿替普酶%用藥劑量%神經功能%病死率
급성결혈성뇌졸중%아체보매%용약제량%신경공능%병사솔
Acute ischemic stroke%Alteplase%Dose%Nerve function%Death rate
目的 对比不同剂量阿替普酶在急性缺血性卒中静脉溶栓中的应用价值.方法 选取入医院治疗的急性缺血脑卒中患者82例作为研究对象,均取阿替普酶行溶栓治疗,根据用药剂量分为对照组和观察组,对照组取低剂量阿替普酶用药(0.6 mg/kg)治疗,观察组取标准剂量(0.9 mg/kg)治疗,行美国国立卫生研究院卒中量表(NIHSS)和改良Rankin量表(mRS)评分,记录用药24 h后阻塞血管再通良好率,观察用药7d和3个月的病死率.结果 观察组用药24 h、3个月NIHSS评分分剐为(6.95±1.29)分、(6.95±1.29)分,均显著低于对照组,mRS评分分别为(1.98±0.86)分、(0.87±0.52)分,均显著低于对照组,差异有统计学意义(P＜0.05).观察组用药24 h后阻塞血管再通良好率为58.54％,显著高于对照组(43.90％),差异有统计学意义(P＜0.05).结论 与低剂量相比,取标准剂量阿替普酶溶栓治疗急性缺血性卒中效果更好,能有效改善神经功能缺损症状.
目的 對比不同劑量阿替普酶在急性缺血性卒中靜脈溶栓中的應用價值.方法 選取入醫院治療的急性缺血腦卒中患者82例作為研究對象,均取阿替普酶行溶栓治療,根據用藥劑量分為對照組和觀察組,對照組取低劑量阿替普酶用藥(0.6 mg/kg)治療,觀察組取標準劑量(0.9 mg/kg)治療,行美國國立衛生研究院卒中量錶(NIHSS)和改良Rankin量錶(mRS)評分,記錄用藥24 h後阻塞血管再通良好率,觀察用藥7d和3箇月的病死率.結果 觀察組用藥24 h、3箇月NIHSS評分分剮為(6.95±1.29)分、(6.95±1.29)分,均顯著低于對照組,mRS評分分彆為(1.98±0.86)分、(0.87±0.52)分,均顯著低于對照組,差異有統計學意義(P＜0.05).觀察組用藥24 h後阻塞血管再通良好率為58.54％,顯著高于對照組(43.90％),差異有統計學意義(P＜0.05).結論 與低劑量相比,取標準劑量阿替普酶溶栓治療急性缺血性卒中效果更好,能有效改善神經功能缺損癥狀.
목적 대비불동제량아체보매재급성결혈성졸중정맥용전중적응용개치.방법 선취입의원치료적급성결혈뇌졸중환자82례작위연구대상,균취아체보매행용전치료,근거용약제량분위대조조화관찰조,대조조취저제량아체보매용약(0.6 mg/kg)치료,관찰조취표준제량(0.9 mg/kg)치료,행미국국립위생연구원졸중량표(NIHSS)화개량Rankin량표(mRS)평분,기록용약24 h후조새혈관재통량호솔,관찰용약7d화3개월적병사솔.결과 관찰조용약24 h、3개월NIHSS평분분과위(6.95±1.29)분、(6.95±1.29)분,균현저저우대조조,mRS평분분별위(1.98±0.86)분、(0.87±0.52)분,균현저저우대조조,차이유통계학의의(P＜0.05).관찰조용약24 h후조새혈관재통량호솔위58.54％,현저고우대조조(43.90％),차이유통계학의의(P＜0.05).결론 여저제량상비,취표준제량아체보매용전치료급성결혈성졸중효과경호,능유효개선신경공능결손증상.
Objective To compare the application value of different doses of alteplase in intravenous thrombolysis of acute ischemic stroke.Methods The 82 patients with acute ischemic stroke were divided into the observation group and the control group based on the dosage of alteplase.The patients in control group were treated with low dose of alteplase (0.6 mg/kg) and the patients in observation group were treated with high dose of alteplase (0.9 mg/kg).NISS and mRS were graded and the recanalization rate of blocked blood vessel 24h after administration were recorded.The death rate on 7days and 3 months after administration were observed.Results NIHSS scores of observation group 24h (6.95 ± 1.29) and 3 months(6.95 ± 1.29) after administration were significantly higher than that of control group (P ＜ 0.05).mRS scores of observation group 24h (1.98 ± 0.86) and 3 months (0.87 ± 0.52) after administration were significantly lower than that of control group (P ＜ 0.05).The recanalization rate of blocked blood vessel in observation group (58.54％) was significantly higher than that of control group(43.90％) (P ＜ 0.05).Conclusions Standard dose of alteplase has better curative effect on acute ischemic stroke than low dose and can relieve the symptoms of nerve function defect.
