中国医药
中國醫藥
중국의약
China Medicine
2015年
12期
1783-1785
,共3页
铂类药物%新辅助化疗%腹腔镜%T1期胃癌%开腹手术
鉑類藥物%新輔助化療%腹腔鏡%T1期胃癌%開腹手術
박류약물%신보조화료%복강경%T1기위암%개복수술
Platinum drugs%Neoadjuvant chemotherapy%Laparoscope%Gastric cancer%Open surgery
目的 探讨应用铂类药物的新辅助化疗(NACT)联合腹腔镜切除治疗T1期胃癌的临床效果.方法 2007年1月至2014年1月广东省江门市中心医院病房收治的240例T1期胃癌患者在应用铂类药物的NACT治疗后,按照患者选择分为腹腔镜手术组(136例)和开腹手术组(104例),对比2组患者的术中淋巴结清扫范围、肿瘤距切缘距离、手术所需时间、术中出血量、术后胃肠功能恢复时间、术后住院天数和近期并发症的发生率.结果 240例患者接受铂类药物的NACT后客观有效率为57.9％(139/240),临床的获益率为89.2％ (214/240).腹腔镜手术组手术所需时间长于开腹手术组,术中出血量、术后胃肠功能恢复时间、术后住院时间均小于开腹手术组,差异有统计学意义[(196±20) min比(168±19)min、(99±45) ml比(177±50) ml、(2.8±0.6)d比(3.3±0.7)d、(7.7±0.9)d比(15.2±1.6)d,P＜0.05],而淋巴结清扫范围、肿瘤距切缘距离以及术后并发症的发生率差异均无统计学意义(P＞0.05).结论 应用铂类药物的NACT联合腹腔镜切除治疗T1期胃癌淋巴结清扫范围与联合开腹手术相似,术中出血少、术后恢复快.
目的 探討應用鉑類藥物的新輔助化療(NACT)聯閤腹腔鏡切除治療T1期胃癌的臨床效果.方法 2007年1月至2014年1月廣東省江門市中心醫院病房收治的240例T1期胃癌患者在應用鉑類藥物的NACT治療後,按照患者選擇分為腹腔鏡手術組(136例)和開腹手術組(104例),對比2組患者的術中淋巴結清掃範圍、腫瘤距切緣距離、手術所需時間、術中齣血量、術後胃腸功能恢複時間、術後住院天數和近期併髮癥的髮生率.結果 240例患者接受鉑類藥物的NACT後客觀有效率為57.9％(139/240),臨床的穫益率為89.2％ (214/240).腹腔鏡手術組手術所需時間長于開腹手術組,術中齣血量、術後胃腸功能恢複時間、術後住院時間均小于開腹手術組,差異有統計學意義[(196±20) min比(168±19)min、(99±45) ml比(177±50) ml、(2.8±0.6)d比(3.3±0.7)d、(7.7±0.9)d比(15.2±1.6)d,P＜0.05],而淋巴結清掃範圍、腫瘤距切緣距離以及術後併髮癥的髮生率差異均無統計學意義(P＞0.05).結論 應用鉑類藥物的NACT聯閤腹腔鏡切除治療T1期胃癌淋巴結清掃範圍與聯閤開腹手術相似,術中齣血少、術後恢複快.
목적 탐토응용박류약물적신보조화료(NACT)연합복강경절제치료T1기위암적림상효과.방법 2007년1월지2014년1월광동성강문시중심의원병방수치적240례T1기위암환자재응용박류약물적NACT치료후,안조환자선택분위복강경수술조(136례)화개복수술조(104례),대비2조환자적술중림파결청소범위、종류거절연거리、수술소수시간、술중출혈량、술후위장공능회복시간、술후주원천수화근기병발증적발생솔.결과 240례환자접수박류약물적NACT후객관유효솔위57.9％(139/240),림상적획익솔위89.2％ (214/240).복강경수술조수술소수시간장우개복수술조,술중출혈량、술후위장공능회복시간、술후주원시간균소우개복수술조,차이유통계학의의[(196±20) min비(168±19)min、(99±45) ml비(177±50) ml、(2.8±0.6)d비(3.3±0.7)d、(7.7±0.9)d비(15.2±1.6)d,P＜0.05],이림파결청소범위、종류거절연거리이급술후병발증적발생솔차이균무통계학의의(P＞0.05).결론 응용박류약물적NACT연합복강경절제치료T1기위암림파결청소범위여연합개복수술상사,술중출혈소、술후회복쾌.
Objective To investigate the effect of platinum based neoadjuvant chemotherapy (NACT)combined with laparoscopic resection in treating stage T1 gastric cancer.Methods Totally 240 patients with stage T1 gastric cancer from January 2007 to January 2014 received platinum based NACT, then were divided into laparoscopy surgery group (136 cases) and open surgery group (104 cases) according to the patient selection.The lymph node cleaning scope, distance from tumor to cut edge, operation duration, intraoperative blood loss, recovery time of gastrointestinal function, postoperative hospitalization duration and the incidence of complications in short term were compared between groups.Results The objective effective rate was 57.9％(139/240) and the clinical benefit rate was 89.2％ (214/240) after NACT.The operation duration in laparoscopy surgery group was significantly longer, the intraoperative blood loss, recovery time of gastrointestinal function and postoperative hospitalization duration were significantly less/shorter than those in open surgery group [(196±20) minvs (168±19) min, (99±45) mlvs (177±50) ml, (2.8±0.6) dvs (3.3±0.7) d,(7.7 ± 0.9) d vs (15.2 ± 1.6) d] (P ＜ 0.05);the lymph node cleaning scope, distance from tumor to cut edge and incidence of postoperative complications were not significantly different between groups (P ＞ 0.05).Conclusion Laparoscopic resection has the same lymph node cleaning scope compared with open surgery in treating T1 stage gastric cancer after platinum drugs based NACT, with less intraoperative bleeding and faster recovery.
