中国医药
中國醫藥
중국의약
China Medicine
2015年
12期
1771-1775
,共5页
唐启令%孙永旭%胡晓帆%陆丛笑
唐啟令%孫永旭%鬍曉帆%陸叢笑
당계령%손영욱%호효범%륙총소
病毒性肝炎%痰热清注射液%总胆红素%天冬氨酸转氨酶%丙氨酸转氨酶%Meta分析
病毒性肝炎%痰熱清註射液%總膽紅素%天鼕氨痠轉氨酶%丙氨痠轉氨酶%Meta分析
병독성간염%담열청주사액%총담홍소%천동안산전안매%병안산전안매%Meta분석
Virus hepatitis%Tanreqing injection%Total bilirubin%Aspartate aminotransferase%Alanine aminotransferase%Meta-analysis
目的 评价痰热清注射液对病毒性肝炎患者肝功能指标的影响,为临床用药提供循证依据.方法 计算机检索中国期刊全文数据库(CNKI)、万方医学网、PubMed和Ovid中英文数据库,检索时限自2003年1月至2014年8月.按纳入与排除标准筛选文献,提取数据和评价纳入研究的方法质量后,采用RevMan 5.3.5软件进行Meta分析.结果 共纳入11个随机对照试验,共864例患者.均分为观察组与对照组,观察组在对照组治疗基础上加用了痰热清.Meta分析结果显示:观察组肝功能指标总胆红素[均数差(MD):15.50,95％置信区间(CI):13.85 ～ 17.15,P＜0.000 01]、天冬氨酸转氨酶(MD:20.42,95％ CI:3.99 ～ 36.84,P=0.01)、丙氨酸转氨酶改善(MD:23.57,95％CI:0.80 ～46.35,P=0.04)均较对照组更明显,差异均有统计学意义(P＜0.05).结论 痰热清注射液治疗病毒性肝炎可明显改善肝功能指标总胆红素、天冬氨酸转氨酶和丙氨酸转氨酶.但本研究纳入文献的质量较低,需更多高质量临床试验支持验证.
目的 評價痰熱清註射液對病毒性肝炎患者肝功能指標的影響,為臨床用藥提供循證依據.方法 計算機檢索中國期刊全文數據庫(CNKI)、萬方醫學網、PubMed和Ovid中英文數據庫,檢索時限自2003年1月至2014年8月.按納入與排除標準篩選文獻,提取數據和評價納入研究的方法質量後,採用RevMan 5.3.5軟件進行Meta分析.結果 共納入11箇隨機對照試驗,共864例患者.均分為觀察組與對照組,觀察組在對照組治療基礎上加用瞭痰熱清.Meta分析結果顯示:觀察組肝功能指標總膽紅素[均數差(MD):15.50,95％置信區間(CI):13.85 ～ 17.15,P＜0.000 01]、天鼕氨痠轉氨酶(MD:20.42,95％ CI:3.99 ～ 36.84,P=0.01)、丙氨痠轉氨酶改善(MD:23.57,95％CI:0.80 ～46.35,P=0.04)均較對照組更明顯,差異均有統計學意義(P＜0.05).結論 痰熱清註射液治療病毒性肝炎可明顯改善肝功能指標總膽紅素、天鼕氨痠轉氨酶和丙氨痠轉氨酶.但本研究納入文獻的質量較低,需更多高質量臨床試驗支持驗證.
목적 평개담열청주사액대병독성간염환자간공능지표적영향,위림상용약제공순증의거.방법 계산궤검색중국기간전문수거고(CNKI)、만방의학망、PubMed화Ovid중영문수거고,검색시한자2003년1월지2014년8월.안납입여배제표준사선문헌,제취수거화평개납입연구적방법질량후,채용RevMan 5.3.5연건진행Meta분석.결과 공납입11개수궤대조시험,공864례환자.균분위관찰조여대조조,관찰조재대조조치료기출상가용료담열청.Meta분석결과현시:관찰조간공능지표총담홍소[균수차(MD):15.50,95％치신구간(CI):13.85 ～ 17.15,P＜0.000 01]、천동안산전안매(MD:20.42,95％ CI:3.99 ～ 36.84,P=0.01)、병안산전안매개선(MD:23.57,95％CI:0.80 ～46.35,P=0.04)균교대조조경명현,차이균유통계학의의(P＜0.05).결론 담열청주사액치료병독성간염가명현개선간공능지표총담홍소、천동안산전안매화병안산전안매.단본연구납입문헌적질량교저,수경다고질량림상시험지지험증.
Objective To evaluate the influence and safety of Tanreqing injection on liver function in virus hepatitis using Meta-analysis.Methods China National Knowledge Infrastructure (CNKI), Wanfang database, PubMed and Ovid database were searched to retrieve the relevant studies from 2003 to August of 2014.According to the including and excluding criteria, the literatures were included, then the data were extracted and the study quality was assessed.Meta-analysis was performed by using RevMan 5.3.5 software.Results Eleven randomized controlled trials including 864 patients were included;the patients were all divided into observation group and control group.Meta-analysis showed that compared with those in control group, the liver function indices such as total bilirubin, aspartate aminotransferase and alanine aminotransferase were better improved in observation group compared with those in control group [mean difference (MD) : 15.50, 95％ confidence interval (CI) :13.85-17.15, P＜0.000 01;MD: 20.42, 95％CI: 3.99-36.84, P=0.01;MD: 23.57, 95％CI: 0.80-46.35,P =0.04].Conclusions Tanreqing injection can effectively improve the liver function indices such as total bilirubin, aspartate aminotransferase and alanine aminotransferase;while more clinical trials with higher quality are need to support the conclusion because the included literatures in this study show low quality.
