中国医药
中國醫藥
중국의약
China Medicine
2015年
12期
1757-1759
,共3页
唐友勇%石明%王正艳%杨中卫%李威%邝军
唐友勇%石明%王正豔%楊中衛%李威%鄺軍
당우용%석명%왕정염%양중위%리위%광군
支气管扩张%基质金属蛋白酶抑制剂%炎性反应%相关性
支氣管擴張%基質金屬蛋白酶抑製劑%炎性反應%相關性
지기관확장%기질금속단백매억제제%염성반응%상관성
Bronchiectasis%Matrix metalloproteinase inhibitors%Inflammation%Correlation
目的 探讨支气管扩张患者血清基质金属蛋白酶组织抑制因子1(TIMP-1)水平及意义.方法 选择2011年8月至2015年1月在湖北医药学院附属东风医院呼吸内科就诊的支气管扩张患者120例作为观察组,选择同期支气管无异常者120名作为对照组,检测2组肺功能、血清基质金属蛋白酶(MMP)、TIMP-1与炎症因子水平,并分析TIMP-1与各指标的相关性.结果 观察组的第1秒用力呼气容积(FEV1)、FEV1/用力呼气容积(FVC)分别为(68±10)％和(70±6)％,而对照组分别为(98±13)％和(85±7)％,观察组的FEV1与FEV1/FVC值明显低于对照组(P＜0.05).观察组血清MMP-2、MMP-9与TIMP-1均明显高于对照组,差异均有统计学意义[(62±11) ng/L比(26±11)ng/L、(134±25) ng/L比(45±13) ng/L、(44 ±9) ng/L比(20 ±9) ng/L,均P＜0.05].观察组与对照组的血清IL-6分别为(41±5)ng/L与(13±4) ng/L,差异有统计学意义(P＜0.05).Pearson相关性分析显示TIMP-1水平与MMP-2、MMP-9、IL-6水平呈明显正相关(r=0.563,r=0.505,r=0.509,均P＜0.05),与FEV1、FEV1/FVC值呈明显负相关(r=-0.438,r=-0.225,均P＜0.05).结论 支气管扩张患者血清TIMP-1与MMP的水平异常增高,与炎性反应及肺功能受限有关,TIMP-1水平检测可辅助判定支气管扩张的病情.
目的 探討支氣管擴張患者血清基質金屬蛋白酶組織抑製因子1(TIMP-1)水平及意義.方法 選擇2011年8月至2015年1月在湖北醫藥學院附屬東風醫院呼吸內科就診的支氣管擴張患者120例作為觀察組,選擇同期支氣管無異常者120名作為對照組,檢測2組肺功能、血清基質金屬蛋白酶(MMP)、TIMP-1與炎癥因子水平,併分析TIMP-1與各指標的相關性.結果 觀察組的第1秒用力呼氣容積(FEV1)、FEV1/用力呼氣容積(FVC)分彆為(68±10)％和(70±6)％,而對照組分彆為(98±13)％和(85±7)％,觀察組的FEV1與FEV1/FVC值明顯低于對照組(P＜0.05).觀察組血清MMP-2、MMP-9與TIMP-1均明顯高于對照組,差異均有統計學意義[(62±11) ng/L比(26±11)ng/L、(134±25) ng/L比(45±13) ng/L、(44 ±9) ng/L比(20 ±9) ng/L,均P＜0.05].觀察組與對照組的血清IL-6分彆為(41±5)ng/L與(13±4) ng/L,差異有統計學意義(P＜0.05).Pearson相關性分析顯示TIMP-1水平與MMP-2、MMP-9、IL-6水平呈明顯正相關(r=0.563,r=0.505,r=0.509,均P＜0.05),與FEV1、FEV1/FVC值呈明顯負相關(r=-0.438,r=-0.225,均P＜0.05).結論 支氣管擴張患者血清TIMP-1與MMP的水平異常增高,與炎性反應及肺功能受限有關,TIMP-1水平檢測可輔助判定支氣管擴張的病情.
목적 탐토지기관확장환자혈청기질금속단백매조직억제인자1(TIMP-1)수평급의의.방법 선택2011년8월지2015년1월재호북의약학원부속동풍의원호흡내과취진적지기관확장환자120례작위관찰조,선택동기지기관무이상자120명작위대조조,검측2조폐공능、혈청기질금속단백매(MMP)、TIMP-1여염증인자수평,병분석TIMP-1여각지표적상관성.결과 관찰조적제1초용력호기용적(FEV1)、FEV1/용력호기용적(FVC)분별위(68±10)％화(70±6)％,이대조조분별위(98±13)％화(85±7)％,관찰조적FEV1여FEV1/FVC치명현저우대조조(P＜0.05).관찰조혈청MMP-2、MMP-9여TIMP-1균명현고우대조조,차이균유통계학의의[(62±11) ng/L비(26±11)ng/L、(134±25) ng/L비(45±13) ng/L、(44 ±9) ng/L비(20 ±9) ng/L,균P＜0.05].관찰조여대조조적혈청IL-6분별위(41±5)ng/L여(13±4) ng/L,차이유통계학의의(P＜0.05).Pearson상관성분석현시TIMP-1수평여MMP-2、MMP-9、IL-6수평정명현정상관(r=0.563,r=0.505,r=0.509,균P＜0.05),여FEV1、FEV1/FVC치정명현부상관(r=-0.438,r=-0.225,균P＜0.05).결론 지기관확장환자혈청TIMP-1여MMP적수평이상증고,여염성반응급폐공능수한유관,TIMP-1수평검측가보조판정지기관확장적병정.
Objective To investigate the level and significance of tissue inhibitor of matrix metalloproteinase 1 (TIMP-1) in serum in patients with bronchial dilation.Methods Totally 120 patients with bronchiectasis (observation group) and 120 subjected with normal bronchial from August 2011 to January 2015 were enrolled.The pulmonary function, the levels of matrix metalloproteinases (MMPs), matrix metalloproteinase inhibitor (TIMP-1) and interleukin (IL)-6 in serum were assessed;the correlations of TIMP-1 with MMPs and IL-6 were analyzed.Results The forced expiratory volume in one second (FEV1) and ratio of FEV1 and forced vital capacity in percentage (FEV1/FVC％) in observation group were significantly lower than those in control group [(68±10)％ vs (98±13)％, (70±6)％ vs (85±7)％] (P＜0.05).The levels of serum MMP-2, MMP-9 and TIMP-1 in observation group were significantly higher compared with those in control group [(62±11)ng/Lvs (26±11) ng/L, (134 ±25) ng/L vs (45 ±13) ng/L, (44 ±9) ng/L vs (20±9) ng/L] (P ＜ 0.05).The level of serum IL-6 in observation group was significantly higher than that in control group [(41 ± 5) ng/L vs (13 ± 4) ng/L] (P ＜ 0.05).Pearson correlation analysis showed that the expression of TIMP-1 was positively correlated with MMP-2, MMP-9 and IL-6 (r =0.563, r =0.505, r =0.509,P ＜0.05), was negatively correlated with FEV1 and FEV1/FVC％ (r =-0.438, r =-0.225, P ＜ 0.05).Conclusion The TIMP-1 and MMPs are abnormally increased in patients with bronchiectasis, which is related with inflammatory reaction and limited lung function;measure of TIMP-1 is helpful to determine the bronchiectasis condition.
