中国医药
中國醫藥
중국의약
China Medicine
2015年
12期
1838-1840
,共3页
纤维支气管镜%瑞芬太尼%七氟烷%小儿
纖維支氣管鏡%瑞芬太尼%七氟烷%小兒
섬유지기관경%서분태니%칠불완%소인
Fiberoptic bronchoscopy%Remifentanil%Sevoflurane%Children
目的 探讨与瑞芬太尼联用时七氟烷抑制小儿纤维支气管镜置入反应的半数效应浓度(EC50)和95％效应浓度(EC95).方法 选择南京医科大学附属淮安第一医院2014年12月至2015年3月美国麻醉医师学会Ⅰ或Ⅱ级,年龄3 ～12岁拟行喉罩下全身麻醉患儿,采用8％七氟烷潮气量诱导法后缓慢静脉注射瑞芬太尼1.5 μg,/kg,随后持续泵注瑞芬太尼0.03～0.06μg/(kg·min),待脑电双频指数(BIS)达到50 ～ 65时置入喉罩,"T型"密封接头连接喉罩与麻醉环路.根据改良Dixon序贯法确定潮气末七氟烷浓度,达预定值并稳定15 min后纤维支气管镜经喉罩进入气管及支气管,置入过程患儿躯干、四肢及头颈有可见的肌束收缩为置入反应阳性,否则为阴性.计算联合瑞芬太尼时七氟烷抑制小儿纤维支气管镜置入反应的EC50、EC95及相应的95％置信区间(CI).结果 本研究共纳入患儿22例.联合瑞芬太尼时七氟烷抑制小儿纤维支气管镜置入反应的EC50为2.30％,95％ CI:2.08％～2.46％;EC95为2.56％,95％ CI:2.42％ ～3.74％.结论 联合瑞芬太尼时七氟烷抑制小儿纤维支气管镜置入反应的EC50为2.30％,EC95为2.56％.
目的 探討與瑞芬太尼聯用時七氟烷抑製小兒纖維支氣管鏡置入反應的半數效應濃度(EC50)和95％效應濃度(EC95).方法 選擇南京醫科大學附屬淮安第一醫院2014年12月至2015年3月美國痳醉醫師學會Ⅰ或Ⅱ級,年齡3 ～12歲擬行喉罩下全身痳醉患兒,採用8％七氟烷潮氣量誘導法後緩慢靜脈註射瑞芬太尼1.5 μg,/kg,隨後持續泵註瑞芬太尼0.03～0.06μg/(kg·min),待腦電雙頻指數(BIS)達到50 ～ 65時置入喉罩,"T型"密封接頭連接喉罩與痳醉環路.根據改良Dixon序貫法確定潮氣末七氟烷濃度,達預定值併穩定15 min後纖維支氣管鏡經喉罩進入氣管及支氣管,置入過程患兒軀榦、四肢及頭頸有可見的肌束收縮為置入反應暘性,否則為陰性.計算聯閤瑞芬太尼時七氟烷抑製小兒纖維支氣管鏡置入反應的EC50、EC95及相應的95％置信區間(CI).結果 本研究共納入患兒22例.聯閤瑞芬太尼時七氟烷抑製小兒纖維支氣管鏡置入反應的EC50為2.30％,95％ CI:2.08％～2.46％;EC95為2.56％,95％ CI:2.42％ ～3.74％.結論 聯閤瑞芬太尼時七氟烷抑製小兒纖維支氣管鏡置入反應的EC50為2.30％,EC95為2.56％.
목적 탐토여서분태니련용시칠불완억제소인섬유지기관경치입반응적반수효응농도(EC50)화95％효응농도(EC95).방법 선택남경의과대학부속회안제일의원2014년12월지2015년3월미국마취의사학회Ⅰ혹Ⅱ급,년령3 ～12세의행후조하전신마취환인,채용8％칠불완조기량유도법후완만정맥주사서분태니1.5 μg,/kg,수후지속빙주서분태니0.03～0.06μg/(kg·min),대뇌전쌍빈지수(BIS)체도50 ～ 65시치입후조,"T형"밀봉접두련접후조여마취배로.근거개량Dixon서관법학정조기말칠불완농도,체예정치병은정15 min후섬유지기관경경후조진입기관급지기관,치입과정환인구간、사지급두경유가견적기속수축위치입반응양성,부칙위음성.계산연합서분태니시칠불완억제소인섬유지기관경치입반응적EC50、EC95급상응적95％치신구간(CI).결과 본연구공납입환인22례.연합서분태니시칠불완억제소인섬유지기관경치입반응적EC50위2.30％,95％ CI:2.08％～2.46％;EC95위2.56％,95％ CI:2.42％ ～3.74％.결론 연합서분태니시칠불완억제소인섬유지기관경치입반응적EC50위2.30％,EC95위2.56％.
Objective To investigate the half effective concentration (EC50) and 95％ effective concentration (ECgs) of sevoflurane combined with remifentanil in inhibiting insertion response of fiberoptic bronchoscopy in children.Methods The patients aged 3-12 years with American society of anesthesiologists Ⅰ or Ⅱ who underwent general anesthesia with laryngeal mask airway (LMA) from December 2014 to March 2015were enrolled.Anesthesia was induced with tidal volume inhalation of 8 ％ sevoflurane, then 1.5 μg/kg remifentanil was intravenously infected, followed by maintain infusion [0.03-0.06 μg/(kg · min)];the LMA was inserted and combined with anesthesia breathing circuit through T-seal adapter when bispectral index get to 50-65.The end-tidal concentration of sevoflurane was determined according to Dixon's up-and-down methods;the fiberoptic bronchoscopy was inserted into trachea and bronchus through LMA after the end-tidal concentration of sevoflurane reached the preset value and stabled for at least 15 min.Any visible contraction of the muscle bundle movement of trunk, limbs, head and neck was marked as positive, otherwise it was marked as negative.The EC50, EC95 and 95％ confidence interval (CI) of sevoflurane were calculated.Results Totally 22 patients were enrolled in this study.The EC50 of sevoflurane was 2.30％ (95％ CI: 2.08％-2.46％) and EC95 was 2.56％ (95％ CI: 2.42％-3.74％) combined with remifentanil in inhibiting insertion response of fiberoptic bronchoscopy.Conclusion The EC50 and EC95 of sevoflurane in inhibiting insertion response of fiberoptic bronchoscopy are 2.30％ and 2.56％combined with remifentanil in children.
