CAJ | 학술논문

目的探讨丁苯酞注射液预防重度一氧化碳中毒迟发性脑病的临床效果.方法 158例重度一氧化碳中毒患者按随机数字表法分为两组.观察组83例,在常规治疗的基础上加用丁苯酞;对照组75例,给予常规治疗未使用丁苯酞.观察指标为3个月内迟发性脑病的发病率及效果.结果观察组出现迟发性脑病5例,发病率6.58％;对照组出现迟发性脑病14例,发病率18.67％;两组比较差异有统计学意义(x2=154.204,P＜0.05).经治疗后两组迟发性脑病患者昏迷量表Glasgow评分分别为(14.00±1.89)分与(13.00±3.30)分,简易精神状态评价量表(MMSE)评分分别为(26.20±2.89)分与(19.57±7.12)分,两组比较差异均有统计学意义(t值分别为1.780、2.003,P均＜0.05).结论早期使用丁苯酞可显著减少迟发性脑病的发病率.
목적 탐토정분태주사액예방중도일양화탄중독지발성뇌병적림상효과.방법 158례중도일양화탄중독환자안수궤수자표법분위량조.관찰조83례,재상규치료적기출상가용정분태;대조조75례,급여상규치료미사용정분태.관찰지표위3개월내지발성뇌병적발병솔급효과.결과 관찰조출현지발성뇌병5례,발병솔6.58％;대조조출현지발성뇌병14례,발병솔18.67％;량조비교차이유통계학의의(x2=154.204,P＜0.05).경치료후량조지발성뇌병환자혼미량표Glasgow평분분별위(14.00±1.89)분여(13.00±3.30)분,간역정신상태평개량표(MMSE)평분분별위(26.20±2.89)분여(19.57±7.12)분,량조비교차이균유통계학의의(t치분별위1.780、2.003,P균＜0.05).결론 조기사용정분태가현저감소지발성뇌병적발병솔.
Objective To evaluate the prevention and treatment effect of butylphthalide injection in delayed encephalopathy after severe carbon monoxide poisoning(DESCMP).Methods One hundred and fiftyeight cases with severe carbon monoxide poisoning (SCMP) were randomly assigned to 2 groups.Observation group (n =83), butylphthalide treatment when SCMP was diagnosed;Control group (n =75), with no butylphthalide therapy.Incidence rate in 3 month, drug amount and the clinical effects of butylphthalide were observed.Results Observation group occurred 5 DEACMP, with the incidence rate of 6.58％, and control group occurred 14 cases,with the incidence rate of 18.67％ ,significant difference was observed in two groups(x2 =154.204,P＜0.05).There were also significant differences in the glasgow coma scale(14.00±1.89 vs.13.00 ±3.30,t =1.780, P＜ 0.05) and mini-mental state examination (26.20± 2.89 vs.19.57 ± 7.12, t =2.003, P＜0.05) between the two groups.Conclusion Early treatment with butylphthalide can decrease the incidence rate of DEACMP.