中国综合临床
中國綜閤臨床
중국종합림상
Clinical Medicine of China
2015年
12期
1067-1070
,共4页
雷海%黄晓蓉%闫珊玲%缪世茜
雷海%黃曉蓉%閆珊玲%繆世茜
뢰해%황효용%염산령%무세천
乳腺癌%前哨淋巴结活检%染料染色%荧光染色
乳腺癌%前哨淋巴結活檢%染料染色%熒光染色
유선암%전초림파결활검%염료염색%형광염색
Breast cancer%Sentinel lymph node biopsy%Dye dyeing%Fluorescence staining
目的 探讨吲哚菁绿荧光染色联合亚甲蓝染料染色标记乳腺癌前哨淋巴结在手术中的应用价值.方法 随机将174例拟行乳腺癌改良根治术的乳腺癌患者分为3组,A组(57例)行亚甲蓝染色前哨淋巴结,B组(58例)行吲哚菁绿荧光染色前哨淋巴结,C组(59例)行吲哚菁绿联合亚甲蓝染色前哨淋巴结.3组患者均行常规前哨淋巴结活检手术,并行腋窝1、2组淋巴结清扫术.术中切除前哨淋巴结及腋窝淋巴结行常规石蜡病理检查.结果 A、B、C组各组间染色阳性率差异无统计学意义(x2=2.96,P=0.241);3组检出淋巴结数组间差异有统计学意义(F=15.34,P＜0.05),A、B组检出前哨淋巴结数差异无统计学意义(P=0.07),C组检出淋巴结数均明显高于A、B组,差异均有统计学意义(P均＜0.05).3组间前哨淋巴结阳性率差异有统计学意义(x2=6.75,P=0.039),其中A、B组前哨淋巴结阳性率比较差异无统计学意义(P=0.915),C组前哨淋巴结阳性率均高于A、B组,差异均有统计学意义(P均＜0.05).结论 荧光染色联合染料染色具有皮上及皮下的双重示踪优势,检出前哨淋巴结数量和腋窝淋巴结阳性患者多于荧光染色及染料染色单独染色方法.
目的 探討吲哚菁綠熒光染色聯閤亞甲藍染料染色標記乳腺癌前哨淋巴結在手術中的應用價值.方法 隨機將174例擬行乳腺癌改良根治術的乳腺癌患者分為3組,A組(57例)行亞甲藍染色前哨淋巴結,B組(58例)行吲哚菁綠熒光染色前哨淋巴結,C組(59例)行吲哚菁綠聯閤亞甲藍染色前哨淋巴結.3組患者均行常規前哨淋巴結活檢手術,併行腋窩1、2組淋巴結清掃術.術中切除前哨淋巴結及腋窩淋巴結行常規石蠟病理檢查.結果 A、B、C組各組間染色暘性率差異無統計學意義(x2=2.96,P=0.241);3組檢齣淋巴結數組間差異有統計學意義(F=15.34,P＜0.05),A、B組檢齣前哨淋巴結數差異無統計學意義(P=0.07),C組檢齣淋巴結數均明顯高于A、B組,差異均有統計學意義(P均＜0.05).3組間前哨淋巴結暘性率差異有統計學意義(x2=6.75,P=0.039),其中A、B組前哨淋巴結暘性率比較差異無統計學意義(P=0.915),C組前哨淋巴結暘性率均高于A、B組,差異均有統計學意義(P均＜0.05).結論 熒光染色聯閤染料染色具有皮上及皮下的雙重示蹤優勢,檢齣前哨淋巴結數量和腋窩淋巴結暘性患者多于熒光染色及染料染色單獨染色方法.
목적 탐토신타정록형광염색연합아갑람염료염색표기유선암전초림파결재수술중적응용개치.방법 수궤장174례의행유선암개량근치술적유선암환자분위3조,A조(57례)행아갑람염색전초림파결,B조(58례)행신타정록형광염색전초림파결,C조(59례)행신타정록연합아갑람염색전초림파결.3조환자균행상규전초림파결활검수술,병행액와1、2조림파결청소술.술중절제전초림파결급액와림파결행상규석사병리검사.결과 A、B、C조각조간염색양성솔차이무통계학의의(x2=2.96,P=0.241);3조검출림파결수조간차이유통계학의의(F=15.34,P＜0.05),A、B조검출전초림파결수차이무통계학의의(P=0.07),C조검출림파결수균명현고우A、B조,차이균유통계학의의(P균＜0.05).3조간전초림파결양성솔차이유통계학의의(x2=6.75,P=0.039),기중A、B조전초림파결양성솔비교차이무통계학의의(P=0.915),C조전초림파결양성솔균고우A、B조,차이균유통계학의의(P균＜0.05).결론 형광염색연합염료염색구유피상급피하적쌍중시종우세,검출전초림파결수량화액와림파결양성환자다우형광염색급염료염색단독염색방법.
Objective To evaluate intraoperative tracing of sentinel lymph node(SLN) by fluorescence staining combined with dye dyeing.Methods A total of 174 patients with breast cancer were randomly divided into three groups : the group A with 57 patients receiving methylene blue (MB), the group B with 58 patients receiving indocyanine green(ICG) as the lymphatic mapping tracers,the group C with 59 patients receiving MB and ICG.The sentinel and axillary lymph node of level Ⅱ, Ⅲ was excised, followed by conventional histopathology.Results There was no significant difference among the three groups in the term of visualized detection rate (x2=2.96, P =0.241).There was statistical significant difference among three groups in the term of detected lymph nodes(F=15.34, P＜0.05).Comparing with the three groups, the number of detected lymph nodes of A and B group had no significant differences(P=0.07) ,the number of detected lymph nodes of C was higher than that of A and B group, and the difference was significant(P＜0.05).There was statistical significant difference among three groups in the term of SLN positive rate (x2 =6.75, P =0.039), and there was no significant difference among A and B group(P=0.915) ,SLN positive rate of C group was higher than than A and B group, and the difference was statistical significant (P＜0.05).Conclusion Intraoperative tracing of SLN by fluorescence staining combined with dye dyeing has the skin and subcutaneous reveal advantage.The use of ICG fluorescence and MB increases lymph node detection rate.
