CAJ | 학술논문

与单一作用靶点的药物相比较 ,中药的作用机制为典型的多成分、多靶点、多途径的整体性治疗 ,各药物之间能够产生协同作用 ,最终达到增效减毒的目的.确证中药作用的靶点 ,对阐明我国传统药物的作用机制具有重要的理论价值 ,也为中药的临床应用提供重要参考.近年来研究表明 ,对中药多组分作用多靶点的探究主要是通过网络药理学、计算机辅助药物设计、蛋白质组学、生物芯片等途径实现.本文综述了近5年在中药作用靶点预测、识别和确证研究中所采用的主要方法和途径 ,为进一步阐明中药的作用靶点提供了参考.
여단일작용파점적약물상비교 ,중약적작용궤제위전형적다성분、다파점、다도경적정체성치료 ,각약물지간능구산생협동작용 ,최종체도증효감독적목적.학증중약작용적파점 ,대천명아국전통약물적작용궤제구유중요적이론개치 ,야위중약적림상응용제공중요삼고.근년래연구표명 ,대중약다조분작용다파점적탐구주요시통과망락약이학、계산궤보조약물설계、단백질조학、생물심편등도경실현.본문종술료근5년재중약작용파점예측、식별화학증연구중소채용적주요방법화도경 ,위진일보천명중약적작용파점제공료삼고.
Compared to the drug with single target ,traditional Chinese medicines (TCM ) with the overall therapeutic effect have the typical mechanism such as multi-components ,multi-targets and multi-channels.In this system ,many compounds together produce a synergistic ef-fect on the purpose of reducing toxicity and improving the therapeutic effect.It is really important for TCM that the molecular mechanism will be clarified and be confirmed.The confirmed targets would provide an important reference for the clinical application of TCM.According to the re-cently studies ,the prediction ,identification and validation of the multi -target that TCM acted on are mainly through network pharmacology , computer-aided drug design ,pr-oteomics and bioship.By reviewing the literature in five years ,this paper would provide a good reference for the methods applying in mechanism studying of TCM.