口腔颌面外科杂志
口腔頜麵外科雜誌
구강합면외과잡지
Journal of Oral and Maxillofacial Surgery
2015年
5期
360-364
,共5页
口腔颌面部%恶性神经鞘瘤%影像学%病理学
口腔頜麵部%噁性神經鞘瘤%影像學%病理學
구강합면부%악성신경초류%영상학%병이학
oral and maxillofacial region%malignant neurilemmoma%radiographic image%pathology
目的:系统分析口腔颌面部恶性神经鞘瘤的影像学和病理学特征,提高对该疾病的认识. 方法:收集2005—2013年我院收治并经病理检查确诊的8例口腔颌面部恶性神经鞘瘤的病历资料, 系统分析其CT和MRI影像学表现,以及组织病理学特征.结果:颌骨内恶性神经鞘瘤的CT检查表现出骨质破坏、牙根吸收等恶性肿瘤特征.而软组织恶性神经鞘瘤的MRI检查表现为边界不清,T1WI呈等信号、T2WI压脂像呈高信号,信号不均匀,有不均匀强化等特点. 病理学上,Vimentin免疫组织化学染色在所有病例的恶性神经鞘瘤细胞中为强阳性,S-100和Ki-67表现为部分肿瘤细胞表达阳性. CD34在7例患者肿瘤细胞中表达为阴性. 结论:CT和MRI影像学检查可帮助确定颌面部恶性神经鞘瘤的性质、范围、形态和破坏程度及与周围组织的关系. Vimentin、S-100和Ki-67免疫组织化学染色可用于肿瘤术后的确诊.
目的:繫統分析口腔頜麵部噁性神經鞘瘤的影像學和病理學特徵,提高對該疾病的認識. 方法:收集2005—2013年我院收治併經病理檢查確診的8例口腔頜麵部噁性神經鞘瘤的病歷資料, 繫統分析其CT和MRI影像學錶現,以及組織病理學特徵.結果:頜骨內噁性神經鞘瘤的CT檢查錶現齣骨質破壞、牙根吸收等噁性腫瘤特徵.而軟組織噁性神經鞘瘤的MRI檢查錶現為邊界不清,T1WI呈等信號、T2WI壓脂像呈高信號,信號不均勻,有不均勻彊化等特點. 病理學上,Vimentin免疫組織化學染色在所有病例的噁性神經鞘瘤細胞中為彊暘性,S-100和Ki-67錶現為部分腫瘤細胞錶達暘性. CD34在7例患者腫瘤細胞中錶達為陰性. 結論:CT和MRI影像學檢查可幫助確定頜麵部噁性神經鞘瘤的性質、範圍、形態和破壞程度及與週圍組織的關繫. Vimentin、S-100和Ki-67免疫組織化學染色可用于腫瘤術後的確診.
목적:계통분석구강합면부악성신경초류적영상학화병이학특정,제고대해질병적인식. 방법:수집2005—2013년아원수치병경병리검사학진적8례구강합면부악성신경초류적병력자료, 계통분석기CT화MRI영상학표현,이급조직병이학특정.결과:합골내악성신경초류적CT검사표현출골질파배、아근흡수등악성종류특정.이연조직악성신경초류적MRI검사표현위변계불청,T1WI정등신호、T2WI압지상정고신호,신호불균균,유불균균강화등특점. 병이학상,Vimentin면역조직화학염색재소유병례적악성신경초류세포중위강양성,S-100화Ki-67표현위부분종류세포표체양성. CD34재7례환자종류세포중표체위음성. 결론:CT화MRI영상학검사가방조학정합면부악성신경초류적성질、범위、형태화파배정도급여주위조직적관계. Vimentin、S-100화Ki-67면역조직화학염색가용우종류술후적학진.
Objective:To review and analyze the clinical characteristics of malignant neurilemmoma in the oral and max-illofacial region in order to raise awareness of the disease. Methods:8 patients (2005—2013) with malignant neurilemmo-ma, the clinicopathologic findings, immunohistochemical expressions, and imaging studies were retrospectively reviewed. Results: Microscopically, malignant neurilemmoma was very cellular and was composed of abundant spindle cells with variable numbers of abnormal mitotic figures. Streaming and palisading of nuclei were often seen. Nuclear pleomorphism may also be prominent. For immunohistochemistry, Vimentin protein was strongly positive in tumor tissues in all eight pa-tients. S-100 and Ki-67 exhibited positive staining in part of tumor cells in all patients, whereas CD34 showed negative staining in tumor tissues in seven patients. CT image of the malignant neurilemmoma of the jaw exhibited features of ma-lignant tumor, such as bony destruction and teeth root resorption. MRI image of the malignant neurilemmoma in the soft tissues showed ill-defined margins, heterogeneous signal and inhomogeneous enhancement. Conclusion:Microscopic sepa-ration of this lesion from other sarcomas may be difficult, making CT and MRI, and immunohistochemistry important diag-nostic adjuncts.
