中国医药
中國醫藥
중국의약
China Medicine
2015年
12期
1737-1741
,共5页
余英%冯妍%王以新%马立萍%杨敏京%乔曼丽%蔡瑾%李亚冬
餘英%馮妍%王以新%馬立萍%楊敏京%喬曼麗%蔡瑾%李亞鼕
여영%풍연%왕이신%마립평%양민경%교만려%채근%리아동
冠状动脉疾病%围绝经期%血脂代谢%炎性因子
冠狀動脈疾病%圍絕經期%血脂代謝%炎性因子
관상동맥질병%위절경기%혈지대사%염성인자
Coronary artery disease%Peri-menopause%Lipid metabolism%Inflammatory factors
目的 探讨围绝经期女性冠状动脉粥样硬化性心脏病(冠心病)患者相关危险因素及心脏功能.方法 选择2013年12月至2014年12月于首都医科大学附属北京安贞医院就诊的围绝经期女性冠心病患者220例作为观察组,另选同一时期男性冠心病患者220例作为对照组,比较2组患者冠状动脉病变特点、各项生化指标、超声心动图指标的差异.结果 观察组冠状动脉单支病变比例明显高于对照组[32.7％(72/220)比16.8％ (37/220)],三支病变和左主干+三支病变比例明显低于对照组[27.7％(61/220)比36.8％(81/220),4.5％(10/220)比12.3％(27/220)],差异均有统计学意义(均P＜0.05).2组双支病变比例差异无统计学意义(P＞0.05).观察组总胆固醇、低密度脂蛋白胆固醇、同型半胱氨酸、C反应蛋白、血尿酸水平明显低于对照组[(4.1±0.9) mmol/L比(4.5±1.2) mmol/L,(2.4±0.8) mmol/L比(2.8±1.0) mmol/L, 10.2(7.4, 13.6) μmol/L比15.3(12.8,20.8)μmol/L,1.11(0.41,2.68) mg/L比2.17(0.69,7.65) mg/L,(319±91)μmol/L比(374±103)μmol/L],高密度脂蛋白胆固醇明显高于对照组[(0.97±0.23) mmol/L比(0.90±0.19) mmol/L],差异有统计学意义(P＜0.05);2组其余指标比较,差异无统计学意义(P＞0.05).观察组左心房内径、左心室舒张末期内径、室间隔厚度、左心室后壁厚度明显小于对照组[(37±7) mm比(42±10)mm,(48±5)mm比(50±6) mm,(9.8±3.8)mm比(10.3± 1.2)mm,(8.9±1.3)mm比(9.8±1.5)mm],左心室射血分数明显高于对照组[(63±10)％比(61±10)％],差异均有统计学意义(p＜0.05).结论 围绝经期女性冠心病患者与男性患者相比血脂水平和动脉粥样硬化风险较低,心脏功能、结构较好.
目的 探討圍絕經期女性冠狀動脈粥樣硬化性心髒病(冠心病)患者相關危險因素及心髒功能.方法 選擇2013年12月至2014年12月于首都醫科大學附屬北京安貞醫院就診的圍絕經期女性冠心病患者220例作為觀察組,另選同一時期男性冠心病患者220例作為對照組,比較2組患者冠狀動脈病變特點、各項生化指標、超聲心動圖指標的差異.結果 觀察組冠狀動脈單支病變比例明顯高于對照組[32.7％(72/220)比16.8％ (37/220)],三支病變和左主榦+三支病變比例明顯低于對照組[27.7％(61/220)比36.8％(81/220),4.5％(10/220)比12.3％(27/220)],差異均有統計學意義(均P＜0.05).2組雙支病變比例差異無統計學意義(P＞0.05).觀察組總膽固醇、低密度脂蛋白膽固醇、同型半胱氨痠、C反應蛋白、血尿痠水平明顯低于對照組[(4.1±0.9) mmol/L比(4.5±1.2) mmol/L,(2.4±0.8) mmol/L比(2.8±1.0) mmol/L, 10.2(7.4, 13.6) μmol/L比15.3(12.8,20.8)μmol/L,1.11(0.41,2.68) mg/L比2.17(0.69,7.65) mg/L,(319±91)μmol/L比(374±103)μmol/L],高密度脂蛋白膽固醇明顯高于對照組[(0.97±0.23) mmol/L比(0.90±0.19) mmol/L],差異有統計學意義(P＜0.05);2組其餘指標比較,差異無統計學意義(P＞0.05).觀察組左心房內徑、左心室舒張末期內徑、室間隔厚度、左心室後壁厚度明顯小于對照組[(37±7) mm比(42±10)mm,(48±5)mm比(50±6) mm,(9.8±3.8)mm比(10.3± 1.2)mm,(8.9±1.3)mm比(9.8±1.5)mm],左心室射血分數明顯高于對照組[(63±10)％比(61±10)％],差異均有統計學意義(p＜0.05).結論 圍絕經期女性冠心病患者與男性患者相比血脂水平和動脈粥樣硬化風險較低,心髒功能、結構較好.
목적 탐토위절경기녀성관상동맥죽양경화성심장병(관심병)환자상관위험인소급심장공능.방법 선택2013년12월지2014년12월우수도의과대학부속북경안정의원취진적위절경기녀성관심병환자220례작위관찰조,령선동일시기남성관심병환자220례작위대조조,비교2조환자관상동맥병변특점、각항생화지표、초성심동도지표적차이.결과 관찰조관상동맥단지병변비례명현고우대조조[32.7％(72/220)비16.8％ (37/220)],삼지병변화좌주간+삼지병변비례명현저우대조조[27.7％(61/220)비36.8％(81/220),4.5％(10/220)비12.3％(27/220)],차이균유통계학의의(균P＜0.05).2조쌍지병변비례차이무통계학의의(P＞0.05).관찰조총담고순、저밀도지단백담고순、동형반광안산、C반응단백、혈뇨산수평명현저우대조조[(4.1±0.9) mmol/L비(4.5±1.2) mmol/L,(2.4±0.8) mmol/L비(2.8±1.0) mmol/L, 10.2(7.4, 13.6) μmol/L비15.3(12.8,20.8)μmol/L,1.11(0.41,2.68) mg/L비2.17(0.69,7.65) mg/L,(319±91)μmol/L비(374±103)μmol/L],고밀도지단백담고순명현고우대조조[(0.97±0.23) mmol/L비(0.90±0.19) mmol/L],차이유통계학의의(P＜0.05);2조기여지표비교,차이무통계학의의(P＞0.05).관찰조좌심방내경、좌심실서장말기내경、실간격후도、좌심실후벽후도명현소우대조조[(37±7) mm비(42±10)mm,(48±5)mm비(50±6) mm,(9.8±3.8)mm비(10.3± 1.2)mm,(8.9±1.3)mm비(9.8±1.5)mm],좌심실사혈분수명현고우대조조[(63±10)％비(61±10)％],차이균유통계학의의(p＜0.05).결론 위절경기녀성관심병환자여남성환자상비혈지수평화동맥죽양경화풍험교저,심장공능、결구교호.
Objective To explore the related risk factors and cardiac function in peri-menopausal patients with coronary heart disease.Methods Totally 220 peri-menopausal female patients with coronary atherosclerotic heart disease from December 2013 to December 2014 were selected as observation group;another 220 male patients with coronary heart disease were matched and selected as control group.The characteristics of coronary artery lesion, biochemical and echocardiographic indicators were compared between the two groups.Results The proportion of single vessel diseases in observation group was significantly higher than that in control group [32.7％(72/220) vs 16.8％ (37/220)], the proportion of three-vessel disease and proportion of left main coronary artery +three-vessel diseases in observation group were significantly lower than those in control group [27.7％(61/220) vs 36.8％ (81/220), 4.5 ％ (10/220) vs 12.3 ％ (27/220)] (both P ＜ 0.05);the proportion of double vessel disease had no significant difference between groups (P ＞ 0.05).The levels of total cholesterol, low density lipoprotein cholesterol, homocysteine, C reactive protein and blood uric acid in observation group were significantly lower than those in control group [(4.1 ±0.9) mmol/L vs (4.5 ± 1.2) mmol/L, (2.4 ±0.8) mmol/L vs (2.8 ±1.0) mmol/L, 10.2 (7.4, 13.6) μmol/L vs 15.3 (12.8, 20.8) μmol/L, 1.11(0.41, 2.68) mg/L vs 2.17 (0.69, 7.65) mg/L, (319 ±91) μmol/L vs (374 ± 103) μmol/L] ,the level of high density lipoprotein cholesterol was significantly higher than that in control group [(0.97 ± 0.23) mmol/L vs (0.90 ± 0.19) mmol/L] (P ＜ 0.05).Other biochemical indicators had no significant differences between groups (P ＞ 0.05).The left atrium diameter, left ventricular end-diastolic diameter, interventricular septum thickness,left ventricular posterior wall thickness in observation group were significantly smaller than those in control group [(37±7) mmvs (42±10) mm, (48±5) mmvs (50±6) mm, (9.8±3.8) mmvs (10.3±1.2) mm,(8.9 ± 1.3) mm vs (9.8 ± 1.5) mm], the left ventricular ejection fraction was significantly higher than that in control group [(63 ± 10) ％ vs (61 ± 10) ％] (P ＜ 0.05).Conclusion The peri-menopausal women with coronary heart disease have lower blood lipid level and atherosclerosis risk, better heart function and structure compared with female patients.
