中华心血管病杂志
中華心血管病雜誌
중화심혈관병잡지
Chinese Journal of Cardiology
2015年
11期
965-968
,共4页
张路%王薇%钟堃%何法霖%王治国
張路%王薇%鐘堃%何法霖%王治國
장로%왕미%종곤%하법림%왕치국
利钠肽,脑%同型半胱氨酸%参考值
利鈉肽,腦%同型半胱氨痠%參攷值
리납태,뇌%동형반광안산%삼고치
Natriuretic peptide,brain%Homocysteine%Reference values
目的 统计2014年中国参加室间质量评价计划实验的血N末端B型利钠肽原(NT-proBNP)、B型利钠肽(BNP)和同型半胱氨酸(homocysteine,Hcy)参考区间来源,并描述决定限的分布.方法 提取卫生部临床检验中心2014年全国NT-proBNP、BNP和Hcy第1次室间质量评价回报结果中参考区间和决定限的相关信息.剔除异常值和错误数据.使用Microsoft Excel 2007和SPSS13.0软件对剩余数据进行分析,包括参考区间来源及决定限分布.并按检测系统对NT-proBNP和BNP进行分组统计,按试剂厂家对Hcy进行分组统计,分析组间差异.结果 有330、119和339个实验室分别上报了血NT-proBNP、BNP和Hcy数据,但其中只有133、54和102家实验室回报了决定限的相关信息.3个项目参考区间来源比例最高的均为试剂厂家说明书[NT-proBNP 76.97％(254/330),BNP 89.08％(106/119),Hcy 83.19％(282/339)].本调查中NT-proBNP、BNP和Hcy分别只有36.53％(122/334)、45.38％(54/119)和47.95％(164/342)的实验室对直接引用的参考区间进行了验证.3个项目决定限的均值和中位数并不接近(NT-proBNP 507.99ng/L和300.00ng/L,BNP 342.72ng/L和100.00ng/L,Hcy 17.34μmol/L和15.00μmol/L),P2.5～P97.5范围广(NT-proBNP125.00～1800.00ng/L,BNP 87.50～4562.50ng/L,Hey 4.15～50.00μmol/L).决定限范围,NT-proBNP为60.00～7000.00ng/L,BNP为80.00～7000.00ng/L,Hcy为1.5～52.00μmol/L.秩和检验示NT-proBNP、BNP和Hcy的P值分别为0.449、0.208和0.754,显示3个项目各组间总体差异均无统计学意义.结论 各实验室血NT-proBNP、BNP和Hcy决定限分布变异性很大,参考区间来源不统一,应尽快建立适应中国人群的参考区间,推进全国参考区间的一致化和标准化.
目的 統計2014年中國參加室間質量評價計劃實驗的血N末耑B型利鈉肽原(NT-proBNP)、B型利鈉肽(BNP)和同型半胱氨痠(homocysteine,Hcy)參攷區間來源,併描述決定限的分佈.方法 提取衛生部臨床檢驗中心2014年全國NT-proBNP、BNP和Hcy第1次室間質量評價迴報結果中參攷區間和決定限的相關信息.剔除異常值和錯誤數據.使用Microsoft Excel 2007和SPSS13.0軟件對剩餘數據進行分析,包括參攷區間來源及決定限分佈.併按檢測繫統對NT-proBNP和BNP進行分組統計,按試劑廠傢對Hcy進行分組統計,分析組間差異.結果 有330、119和339箇實驗室分彆上報瞭血NT-proBNP、BNP和Hcy數據,但其中隻有133、54和102傢實驗室迴報瞭決定限的相關信息.3箇項目參攷區間來源比例最高的均為試劑廠傢說明書[NT-proBNP 76.97％(254/330),BNP 89.08％(106/119),Hcy 83.19％(282/339)].本調查中NT-proBNP、BNP和Hcy分彆隻有36.53％(122/334)、45.38％(54/119)和47.95％(164/342)的實驗室對直接引用的參攷區間進行瞭驗證.3箇項目決定限的均值和中位數併不接近(NT-proBNP 507.99ng/L和300.00ng/L,BNP 342.72ng/L和100.00ng/L,Hcy 17.34μmol/L和15.00μmol/L),P2.5～P97.5範圍廣(NT-proBNP125.00～1800.00ng/L,BNP 87.50～4562.50ng/L,Hey 4.15～50.00μmol/L).決定限範圍,NT-proBNP為60.00～7000.00ng/L,BNP為80.00～7000.00ng/L,Hcy為1.5～52.00μmol/L.秩和檢驗示NT-proBNP、BNP和Hcy的P值分彆為0.449、0.208和0.754,顯示3箇項目各組間總體差異均無統計學意義.結論 各實驗室血NT-proBNP、BNP和Hcy決定限分佈變異性很大,參攷區間來源不統一,應儘快建立適應中國人群的參攷區間,推進全國參攷區間的一緻化和標準化.
목적 통계2014년중국삼가실간질량평개계화실험적혈N말단B형리납태원(NT-proBNP)、B형리납태(BNP)화동형반광안산(homocysteine,Hcy)삼고구간래원,병묘술결정한적분포.방법 제취위생부림상검험중심2014년전국NT-proBNP、BNP화Hcy제1차실간질량평개회보결과중삼고구간화결정한적상관신식.척제이상치화착오수거.사용Microsoft Excel 2007화SPSS13.0연건대잉여수거진행분석,포괄삼고구간래원급결정한분포.병안검측계통대NT-proBNP화BNP진행분조통계,안시제엄가대Hcy진행분조통계,분석조간차이.결과 유330、119화339개실험실분별상보료혈NT-proBNP、BNP화Hcy수거,단기중지유133、54화102가실험실회보료결정한적상관신식.3개항목삼고구간래원비례최고적균위시제엄가설명서[NT-proBNP 76.97％(254/330),BNP 89.08％(106/119),Hcy 83.19％(282/339)].본조사중NT-proBNP、BNP화Hcy분별지유36.53％(122/334)、45.38％(54/119)화47.95％(164/342)적실험실대직접인용적삼고구간진행료험증.3개항목결정한적균치화중위수병불접근(NT-proBNP 507.99ng/L화300.00ng/L,BNP 342.72ng/L화100.00ng/L,Hcy 17.34μmol/L화15.00μmol/L),P2.5～P97.5범위엄(NT-proBNP125.00～1800.00ng/L,BNP 87.50～4562.50ng/L,Hey 4.15～50.00μmol/L).결정한범위,NT-proBNP위60.00～7000.00ng/L,BNP위80.00～7000.00ng/L,Hcy위1.5～52.00μmol/L.질화검험시NT-proBNP、BNP화Hcy적P치분별위0.449、0.208화0.754,현시3개항목각조간총체차이균무통계학의의.결론 각실험실혈NT-proBNP、BNP화Hcy결정한분포변이성흔대,삼고구간래원불통일,응진쾌건립괄응중국인군적삼고구간,추진전국삼고구간적일치화화표준화.
Objective To analyze the sources of reference intervals and distribution of medical decision levels in NT-proBNP,BNP and homocysteine (Hcy) based on the feedback of laboratories which participated in the 2014 External Quality Assessment (EQA) program in China.Methods Information of reference intervals and medical decision levels was collected from the 2014 EQA programs in NT-proBNP,BNP and Hcy.All the abnormal values and errors were eliminated.Data were analyzed by SPSS 13.0 and Microsoft Excel 2007 in terms of referring to sources of reference intervals and distribution of medical decision levels.Values were further grouped based on instrument system for NT-proBNP and BNP,reagent manufacturers for Hcy.Results There were 330,119 and 339 laboratories submitting the data on the reference intervals of NT-proBNP,BNP and Hcy.Only 133,54 and 102 laboratories provided iffformation about medical decision levels.Most reference sources were derived from reagent manufactures (NT-proBNP 76.97％ (254/330),BNP 89.08％ (106/119),Hcy 83.19％ (282/339)).Approximately,36.53％ (122/334),45.38％ (54/119) and 47.95％ (164/342) of the laboratories validated the reference intervals of NT-proBNP,BNP and Hcy.According to the surveys,the mean and median values were not close to each other (NT-proBNP 507.99ng/L and 300.00ng/L,BNP 342.72ng/L and 100.00ng/L,Hcy 17.34μmoL/L and 15.00μmol/L).Variation of P2.5 and P97.5 was as follows:(NT-proBNP 125.00-1800.00ng/L,BNP 87.50-4562.50ng/L,Hcy 4.15-50.00μmol/L).The ranges were NT-proBNP 60.00-7000.00ng/L,and BNP 80.00-7000.00ng/L,and Hcy 1.5-52.00μmol/L.Pvalues of rank sum test for NT-proBNP,BNP and Hcy were 0.449,0.208 and 0.754.Conclusions Medical decision levels of NT-proBNP,Hcy and BNP showed large variation among laboratories and the sources of reference interval were not unified.Thus,urgent efforts should be made to establish appropriate reference intervals for Chinese people and promote harmonization and standardization of reference intervals and medical decision levels on BNP,NT-proBNP and Hcy.
