国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
International Journal of Pediatrics
2015年
6期
693-697
,共5页
毛细支气管炎%呼吸道合胞病毒%临床评分%病情%儿童
毛細支氣管炎%呼吸道閤胞病毒%臨床評分%病情%兒童
모세지기관염%호흡도합포병독%림상평분%병정%인동
Bronchiolitis%Respiratory syncytial virus%Clinical score%Disease severity%Children
目的 探讨呼吸道合胞病毒(respiratory syncytial virus,RSV)感染及非RSV感染毛细支气管炎的临床特征及病情严重度特点.方法 选取2012年11月至2014年3月毛细支气管炎住院患儿96例.采用直接免疫荧光法检测RSV抗原,根据检测结果分成RSV感染组和非RSV感染组,对比两组患儿人口学资料、过敏状况等临床特征.两组用改良Tal评分法进行临床评分,并分析临床评分与发病天数及住院天数的相关性以评价病情严重度.结果 共筛选入组毛细支气管炎患儿96例,RSV感染组为40例(41.67％).与非RSV感染的毛细支气管炎患儿相比,RSV感染者住院年龄小(t=-2.706,P=0.008),体重低(t=-2.070,P=0.041),而性别比例、出生方式、出生体重、身长等差异均无统计学意义(P＞0.05).两组患儿湿疹史、过敏性家族史及血清总IgE差异无统计学意义(P＞0.05).从病情严重程度对比来看,RSV感染组临床评分显著高于非RSV感染者(t=-0.405,P＜0.001),住院时间有延长趋势(t=0.480,P=0.081).临床评分与住院天数呈正相关(r=0.305,P=0.003),与发病天数无显著相关性(P＞0.05).结论 RSV感染的毛支气管炎患儿年龄偏小,体重偏低,临床评分较高提示病情较重.毛细支气管炎的临床评分与住院天数呈正相关.结合病原学检查及改良的Tal评分系统,可有助于早期识别重症毛细支气管炎患儿,早期给予严密观察和及时有效的治疗.
目的 探討呼吸道閤胞病毒(respiratory syncytial virus,RSV)感染及非RSV感染毛細支氣管炎的臨床特徵及病情嚴重度特點.方法 選取2012年11月至2014年3月毛細支氣管炎住院患兒96例.採用直接免疫熒光法檢測RSV抗原,根據檢測結果分成RSV感染組和非RSV感染組,對比兩組患兒人口學資料、過敏狀況等臨床特徵.兩組用改良Tal評分法進行臨床評分,併分析臨床評分與髮病天數及住院天數的相關性以評價病情嚴重度.結果 共篩選入組毛細支氣管炎患兒96例,RSV感染組為40例(41.67％).與非RSV感染的毛細支氣管炎患兒相比,RSV感染者住院年齡小(t=-2.706,P=0.008),體重低(t=-2.070,P=0.041),而性彆比例、齣生方式、齣生體重、身長等差異均無統計學意義(P＞0.05).兩組患兒濕疹史、過敏性傢族史及血清總IgE差異無統計學意義(P＞0.05).從病情嚴重程度對比來看,RSV感染組臨床評分顯著高于非RSV感染者(t=-0.405,P＜0.001),住院時間有延長趨勢(t=0.480,P=0.081).臨床評分與住院天數呈正相關(r=0.305,P=0.003),與髮病天數無顯著相關性(P＞0.05).結論 RSV感染的毛支氣管炎患兒年齡偏小,體重偏低,臨床評分較高提示病情較重.毛細支氣管炎的臨床評分與住院天數呈正相關.結閤病原學檢查及改良的Tal評分繫統,可有助于早期識彆重癥毛細支氣管炎患兒,早期給予嚴密觀察和及時有效的治療.
목적 탐토호흡도합포병독(respiratory syncytial virus,RSV)감염급비RSV감염모세지기관염적림상특정급병정엄중도특점.방법 선취2012년11월지2014년3월모세지기관염주원환인96례.채용직접면역형광법검측RSV항원,근거검측결과분성RSV감염조화비RSV감염조,대비량조환인인구학자료、과민상황등림상특정.량조용개량Tal평분법진행림상평분,병분석림상평분여발병천수급주원천수적상관성이평개병정엄중도.결과 공사선입조모세지기관염환인96례,RSV감염조위40례(41.67％).여비RSV감염적모세지기관염환인상비,RSV감염자주원년령소(t=-2.706,P=0.008),체중저(t=-2.070,P=0.041),이성별비례、출생방식、출생체중、신장등차이균무통계학의의(P＞0.05).량조환인습진사、과민성가족사급혈청총IgE차이무통계학의의(P＞0.05).종병정엄중정도대비래간,RSV감염조림상평분현저고우비RSV감염자(t=-0.405,P＜0.001),주원시간유연장추세(t=0.480,P=0.081).림상평분여주원천수정정상관(r=0.305,P=0.003),여발병천수무현저상관성(P＞0.05).결론 RSV감염적모지기관염환인년령편소,체중편저,림상평분교고제시병정교중.모세지기관염적림상평분여주원천수정정상관.결합병원학검사급개량적Tal평분계통,가유조우조기식별중증모세지기관염환인,조기급여엄밀관찰화급시유효적치료.
Objective To investigate the differences of clinical characteristics and disease severity between respiratory syncytial virus (RSV) and non-RSV bronchiolitis.Methods Ninety-six bronchiolitis inpatients of Shengjing Hospital from November 2012 to March 2014 were enrolled.RSV detection was performed at enrollment by direct immunofluorescence assay and the patients were divided into RSV group and non-RSV group.Clinical characteristics were collected and compared, including patients' demographic data, allergy, etc.Clinical scores were assessed by modified-Tal score system, and the associations between clinical scores and duration of onset or length of stay were analyzed to assess disease severity.Results In all 96 patients, forty (46.17％) were determined to be infected with RSV.Patients with RSV bronchiolitis were younger at hospitalization (t =-2.706,P =0.008) and the weight was lower (t =-2.070, P =0.041).There was no significant differences in sex, birth way, birth weight, height, ete (P ＞ 0.05).There was no significant differences in eczema, history of family allergy and total serum IgE (P ＞ 0.05).For patients with RSV bronchiolitis, the clinical scores were higher (t =-0.405 ,P ＜0.001) and the length of stay trended to be longer (t =0.480 ,P =0.081).The clinical score had a positive relation with length of stay (r =0.305, P =0.003), but not with the duration of onset (P ＞ 0.05).Conclusion Compared with non-RSV bronchiolitis, the clinical characteristics of patients with RSV bronchiolitis are younger age and lower weight, and have higher clinical scores, which indicates the clinical conditions may be more severe.For bronchiolitis, there is a positive correlation between clinical score and length of stay.The combination of etiological detection and modified-Tal score system may help to recognize severe cases, which should be observed carefully and treated immediately.
