CAJ | 학술논문

局灶节段性肾小球硬化(focal segmental glomerulosclerosis,FSGS)是儿童及成人终末期肾脏病最多见的病理类型,也是肾移植后复发最常见的原因.其发病机制仍未完全明确,但近年来随着对FSGS特别是遗传性FSGS突变基因研究的不断深入,人们已明确足细胞在FSGS发生发展中的重要作用,越来越多的与FSGS有关的足细胞突变基因被报道.同时,可溶性尿激酶型纤维酶原激活物受体在FSGS肾移植后复发中的重要作用也成为研究热点.该文就FSGS发病机制的研究进展作一综述.
국조절단성신소구경화(focal segmental glomerulosclerosis,FSGS)시인동급성인종말기신장병최다견적병리류형,야시신이식후복발최상견적원인.기발병궤제잉미완전명학,단근년래수착대FSGS특별시유전성FSGS돌변기인연구적불단심입,인문이명학족세포재FSGS발생발전중적중요작용,월래월다적여FSGS유관적족세포돌변기인피보도.동시,가용성뇨격매형섬유매원격활물수체재FSGS신이식후복발중적중요작용야성위연구열점.해문취FSGS발병궤제적연구진전작일종술.
Focal segmental glomerulosclerosis (FSGS) is the main pathologic type that causes end-stage kidney diseases and the recurrence after kidney transplantation.So far, the pathogenesis of FSGS is still not entirely clear.However, more and more mutations have been reported on the FSGS, especially on the genetic FSGS.It is clear that podocyte plays an important role in the development of FSGS.At the same time, the role of soluble urokinase-type plasminogen activator receptor in the recurrence after kidney transplantation has become the research focus.This article will make a brief review on the progress of the pathogenesis of FSGS.