CAJ | 학술논문

晚期肺发育发生在胚胎小管期以后,这一阶段初级隔膜转化为次级隔膜,产生大量的小型肺泡,扩大气体交换的表面积,次级化分隔作用和肺血管结构的改变是晚期肺发育的关键环节.近年来研究表明晚期肺发育障碍参与了支气管肺发育不良的病理过程.支气管肺发育不良是一种肺泡发育障碍的新生儿肺部疾病,由炎症、气压伤和氧中毒等多种因素所致,和晚期肺发育障碍互为因果.该文对晚期肺发育障碍与支气管肺发育不良的最新研究进展作一综述.
만기폐발육발생재배태소관기이후,저일계단초급격막전화위차급격막,산생대량적소형폐포,확대기체교환적표면적,차급화분격작용화폐혈관결구적개변시만기폐발육적관건배절.근년래연구표명만기폐발육장애삼여료지기관폐발육불량적병리과정.지기관폐발육불량시일충폐포발육장애적신생인폐부질병,유염증、기압상화양중독등다충인소소치,화만기폐발육장애호위인과.해문대만기폐발육장애여지기관폐발육불량적최신연구진전작일종술.
The process of late lung development is disturbed in bronchopulmonary dysplasia (BPD).One of the keys in late lung development is secondary septation, in which secondary septa arise from primary septa, producing plenty of small alveoli, which significantly increase the surface area of gas exchange.Secondary septation,together with architectural changes to the vascular structure of the lung which minimize the distance between the blood and the inspired air, are the targets of late lung development.BPD is a disease of premature infants in which development of the alveoli is stunted caused by many factors including volutrauma,inflammation,and oxygen toxicity.Compared with early lung development, the later development of the immature lung remains unclear.This paper is to emphasize remarkable latest research of arrested late lung development and BPD.