CAJ | 학술논문

胃肠道肿瘤是世界上发病率和死亡率最高的的肿瘤之一,近年来发病率呈增高趋势,很大一部分患者在确诊时已进入晚期,至今仍没有一种能在早期筛选患癌高风险人群的可靠的标记物.有研究认为,Lgr4在胃肠道肿瘤中阳性表达率较高,Lgr4被建议用于胃肠道肿瘤的诊断、鉴别诊断及预后判断中.Lgr4是G蛋白耦联受体家族成员之一,介导Wnt信号通路,在多种器官的发生发展中起重要作用.近年来,有研究发现kr4与结直肠癌及胃癌等胃肠道肿瘤的发生、发展密切相关,本文就kr4在胃肠道肿瘤中的研究进展作一概述.
위장도종류시세계상발병솔화사망솔최고적적종류지일,근년래발병솔정증고추세,흔대일부분환자재학진시이진입만기,지금잉몰유일충능재조기사선환암고풍험인군적가고적표기물.유연구인위,Lgr4재위장도종류중양성표체솔교고,Lgr4피건의용우위장도종류적진단、감별진단급예후판단중.Lgr4시G단백우련수체가족성원지일,개도Wnt신호통로,재다충기관적발생발전중기중요작용.근년래,유연구발현kr4여결직장암급위암등위장도종류적발생、발전밀절상관,본문취kr4재위장도종류중적연구진전작일개술.
Gastrointestinal carcinomas, whose incidence increases in recent years, are among the malignancies with highest morbidity and mortality.Many patients are always advanced stages when having diagnosis.So far, there are no any reliable tumor biomarkers which are able to screen people with high risk of developing cancer.Studies have shown that the expression level of Lgr4 is high in gastrointestinal carcinomas and Lgr4 is useful in diagnosis, differential diagnosis and prognosis judgment of these carcinomas.Lgr4 belongs to the G-protein-coupled receptors family.Its function is to potentiate Wnt signaling and plays an important role in the development of multiple organs.Recent studies find that Lgr4 has close relationship with the development of many gastrointestinal carcinomas, such as gastric cancer and colorectal cancer (CRC).In this article we review recent progress in understanding the relationship between Lgr4 and gastrointestinal carcinomas.