国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
International Journal of Pediatrics
2015年
6期
603-606
,共4页
Kv1.3钾离子通道%T细胞%自身免疫性疾病%肿瘤
Kv1.3鉀離子通道%T細胞%自身免疫性疾病%腫瘤
Kv1.3갑리자통도%T세포%자신면역성질병%종류
Kv1.3 potassium channel%T lymphocyte%Autoimmune disease%Tumor
Kv1.3钾离子通道在T细胞活化中有着关键性作用,在T细胞介导的许多疾病中,如多发性硬化、风湿性关节炎、系统性红斑狼疮、抗肾小球基膜型肾小球肾炎、哮喘,发病时Kv1.3钾离子通道表达均上调,与其发病机制密切相关.在心血管系统疾病中,Kv1.3钾离子通道蛋白与单核细胞源性巨噬细胞向泡沫细胞分化过程以及血管重塑过程有关.此外Kv1.3钾离子通道参与细胞凋亡过程.为T细胞介导的系列疾病、心血管系统疾病以及肿瘤的诊治提供新思路.
Kv1.3鉀離子通道在T細胞活化中有著關鍵性作用,在T細胞介導的許多疾病中,如多髮性硬化、風濕性關節炎、繫統性紅斑狼瘡、抗腎小毬基膜型腎小毬腎炎、哮喘,髮病時Kv1.3鉀離子通道錶達均上調,與其髮病機製密切相關.在心血管繫統疾病中,Kv1.3鉀離子通道蛋白與單覈細胞源性巨噬細胞嚮泡沫細胞分化過程以及血管重塑過程有關.此外Kv1.3鉀離子通道參與細胞凋亡過程.為T細胞介導的繫列疾病、心血管繫統疾病以及腫瘤的診治提供新思路.
Kv1.3갑리자통도재T세포활화중유착관건성작용,재T세포개도적허다질병중,여다발성경화、풍습성관절염、계통성홍반랑창、항신소구기막형신소구신염、효천,발병시Kv1.3갑리자통도표체균상조,여기발병궤제밀절상관.재심혈관계통질병중,Kv1.3갑리자통도단백여단핵세포원성거서세포향포말세포분화과정이급혈관중소과정유관.차외Kv1.3갑리자통도삼여세포조망과정.위T세포개도적계렬질병、심혈관계통질병이급종류적진치제공신사로.
Kvl.3 potassium channel plays a key role in T lymphocyte activation.In many diseases mediated by T lymphocytes, such as multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, anti-glomerular basement membrane glomerulonephritis, asthma, Kv1.3 potassium channel expression is up-regulated,closely related to the mechanism of those disease.In the cardiovascular system diseases, Kv1.3 potassium channel protein is related to the differentiation of monocyte derived macrophage into foam cells, and vascular remodeling.In addition Kv1.3 potassium channel plays a role in apoptosis.This paper provide new ideas for the diagnosis and treatment of T lymphocytes mediated disease, cardiovascular disease and neoplasms.
