交通医学
交通醫學
교통의학
Medical Journal of Communications
2015年
5期
425-428
,共4页
吕秀芳%赵奉波%巩秀%孙长江
呂秀芳%趙奉波%鞏秀%孫長江
려수방%조봉파%공수%손장강
肝细胞性肝癌%神经肽Y%骨桥蛋白%α-甲胎蛋白
肝細胞性肝癌%神經肽Y%骨橋蛋白%α-甲胎蛋白
간세포성간암%신경태Y%골교단백%α-갑태단백
hepatocellular carcinoma%neuropeptide Y%osteopontin%alpha-fetoprotein
目的:探讨神经肽Y(Neuropeptide Y,NPY)和骨桥蛋白(Osteopontin,OPN)在肝细胞肝癌(hepatocellular carcinoma,HCC)诊断中潜在的应用价值.方法:收集各类受试者血清,其中慢性乙型肝炎(chronic hepatitis B,CHB)65例、肝硬化(liver cirrhosis,LC)74例、HCC患者53例、健康志愿者68例作为正常对照(health control,HC).以酶联免疫法检测受试者血清中NPY、OPN和α-甲胎蛋白(alpha-fetoprotein,AFP)含量,分析NPY、OPN在HCC诊断中的应用价值并与AFP进行比较.结果:HCC患者血清NPY显著高于HC组、CHB组及LC组(F=59.63,P<0.0001);HCC患者血清OPN显著高于HC组、CHB组及LC组(F=36.00,P<0.0001);与HC组相比,受试者工作曲线(ROC)下面积分别为NPY=0.924±0.025,OPN=0.864±0.036;NPY对HCC诊断灵敏度和特异度分别为79.28%、98.53%;OPN对HCC诊断灵敏度和特异度分别为83.02%、82.35%,与AFP相比,NPY特异性最强,OPN灵敏度最高.结论:血清NPY和OPN是潜在的HCC诊断标志物,与AFP联合诊断对HCC的诊断价值更高.
目的:探討神經肽Y(Neuropeptide Y,NPY)和骨橋蛋白(Osteopontin,OPN)在肝細胞肝癌(hepatocellular carcinoma,HCC)診斷中潛在的應用價值.方法:收集各類受試者血清,其中慢性乙型肝炎(chronic hepatitis B,CHB)65例、肝硬化(liver cirrhosis,LC)74例、HCC患者53例、健康誌願者68例作為正常對照(health control,HC).以酶聯免疫法檢測受試者血清中NPY、OPN和α-甲胎蛋白(alpha-fetoprotein,AFP)含量,分析NPY、OPN在HCC診斷中的應用價值併與AFP進行比較.結果:HCC患者血清NPY顯著高于HC組、CHB組及LC組(F=59.63,P<0.0001);HCC患者血清OPN顯著高于HC組、CHB組及LC組(F=36.00,P<0.0001);與HC組相比,受試者工作麯線(ROC)下麵積分彆為NPY=0.924±0.025,OPN=0.864±0.036;NPY對HCC診斷靈敏度和特異度分彆為79.28%、98.53%;OPN對HCC診斷靈敏度和特異度分彆為83.02%、82.35%,與AFP相比,NPY特異性最彊,OPN靈敏度最高.結論:血清NPY和OPN是潛在的HCC診斷標誌物,與AFP聯閤診斷對HCC的診斷價值更高.
목적:탐토신경태Y(Neuropeptide Y,NPY)화골교단백(Osteopontin,OPN)재간세포간암(hepatocellular carcinoma,HCC)진단중잠재적응용개치.방법:수집각류수시자혈청,기중만성을형간염(chronic hepatitis B,CHB)65례、간경화(liver cirrhosis,LC)74례、HCC환자53례、건강지원자68례작위정상대조(health control,HC).이매련면역법검측수시자혈청중NPY、OPN화α-갑태단백(alpha-fetoprotein,AFP)함량,분석NPY、OPN재HCC진단중적응용개치병여AFP진행비교.결과:HCC환자혈청NPY현저고우HC조、CHB조급LC조(F=59.63,P<0.0001);HCC환자혈청OPN현저고우HC조、CHB조급LC조(F=36.00,P<0.0001);여HC조상비,수시자공작곡선(ROC)하면적분별위NPY=0.924±0.025,OPN=0.864±0.036;NPY대HCC진단령민도화특이도분별위79.28%、98.53%;OPN대HCC진단령민도화특이도분별위83.02%、82.35%,여AFP상비,NPY특이성최강,OPN령민도최고.결론:혈청NPY화OPN시잠재적HCC진단표지물,여AFP연합진단대HCC적진단개치경고.
Objective:To explore the diagnostic value of Neuropeptide Y (NPY) and Osteopontin (OPN) in patients with hepatocellular carcinoma (HCC). Methods:Serum of 65 patients with chronic hepatitis B (CHB), 74 patients with liver cirrhosis (LC), 53 patients with HCC, and 68 health people as control (HC) were collected. Serum levels of NPY, OPN, and alpha-fetoprotein (AFP) were detected by enzyme linked immunosorbent assay (ELISA). The value of them in the diagnosis of HCC was analyzed by receiver operating characteristic curve (ROC). Results:Serum NPY (F=59.63, P<0.0001) and OPN (F=36.00, P<0.0001) levels were significantly higher in HCC patients than in HC, CHB and LC. Area under ROC curve of NPY is 0.924 ±0.025 and OPN is 0.864 ±0.036. The specificity and sensitivity of NPY are 79.28% and 98.53%, OPN are 83.02%、82.35%. Compared with AFP, the specificity of NPY is the strongest and the sensitivity of OPN is the highest. Conclusion:Serum NPY and OPN is a potential diagnostic marker for HCC. The combined use of NPY, OPN, and AFP as biomarker panel could enhance the diagnostic ability for HCC.
