中华肿瘤杂志
中華腫瘤雜誌
중화종류잡지
Chinese Journal of Oncology
2015年
11期
827-832
,共6页
谭林深%秦海明%朴瑛%刘兆喆%韩雅玲%宋福林%谢晓冬
譚林深%秦海明%樸瑛%劉兆喆%韓雅玲%宋福林%謝曉鼕
담림심%진해명%박영%류조철%한아령%송복림%사효동
乳腺肿瘤%异黏蛋白%血管内皮生长因子%预后
乳腺腫瘤%異黏蛋白%血管內皮生長因子%預後
유선종류%이점단백%혈관내피생장인자%예후
Breast neoplasms%Metadherin%Vascular endothelial growth factor%Prognosis
目的 探讨异黏蛋白(MTDH)和血管内皮生长因子(VEGF)在三阴性乳腺癌组织中的表达及其临床意义.方法 收集168例乳腺癌(其中三阴性乳腺癌112例和非三阴性乳腺癌56例)、10例乳腺纤维腺瘤和15例正常乳腺组织标本及临床资料,采用免疫组化法检测MTDH和VEGF蛋白的表达,并结合临床资料分析其临床意义.结果 168例乳腺癌组织中,MTDH和VEGF蛋白的高表达率分别为57.1％(96/168)和49.4％ (83/168).MTDH和VEGF蛋白在三阴性乳腺癌组织中的高表达率分别为64.3％(72/112)和56.3％ (63/112),高于非三阴性乳腺癌组织(42.9％和35.7％)、乳腺纤维腺瘤(10.0％和20.0％)和正常乳腺组织(0.0％和0.0％),差异均有统计学意义(均P＜0.05).三阴性乳腺癌组织中MTDH蛋白与VEGF蛋白的表达呈低度正相关(r=0.356,P＜0.001).MTDH蛋白表达与三阴性乳腺癌的肿瘤大小、体质指数(BMI)、腋窝淋巴结转移、病理分期、p53状态、Ki-67状态和复发转移有关(均P＜0.05);VEGF蛋白表达与三阴性乳腺癌的腋窝淋巴结转移、病理分期、Ki-67状态和复发转移有关(均P＜0.05).MTDH和VEGF蛋白高表达组的三阴性乳腺癌患者无病生存时间和总生存时间明显低于MTDH和VEGF蛋白低表达组,差异均有统计学意义(均P＜0.05).结论 在三阴性乳腺癌中,MTDH蛋白可能与VEGF蛋白对肿瘤血管生成的调节有关;MTDH和VEGF蛋白表达有可能成为三阴性乳腺癌有价值的预后指标.
目的 探討異黏蛋白(MTDH)和血管內皮生長因子(VEGF)在三陰性乳腺癌組織中的錶達及其臨床意義.方法 收集168例乳腺癌(其中三陰性乳腺癌112例和非三陰性乳腺癌56例)、10例乳腺纖維腺瘤和15例正常乳腺組織標本及臨床資料,採用免疫組化法檢測MTDH和VEGF蛋白的錶達,併結閤臨床資料分析其臨床意義.結果 168例乳腺癌組織中,MTDH和VEGF蛋白的高錶達率分彆為57.1％(96/168)和49.4％ (83/168).MTDH和VEGF蛋白在三陰性乳腺癌組織中的高錶達率分彆為64.3％(72/112)和56.3％ (63/112),高于非三陰性乳腺癌組織(42.9％和35.7％)、乳腺纖維腺瘤(10.0％和20.0％)和正常乳腺組織(0.0％和0.0％),差異均有統計學意義(均P＜0.05).三陰性乳腺癌組織中MTDH蛋白與VEGF蛋白的錶達呈低度正相關(r=0.356,P＜0.001).MTDH蛋白錶達與三陰性乳腺癌的腫瘤大小、體質指數(BMI)、腋窩淋巴結轉移、病理分期、p53狀態、Ki-67狀態和複髮轉移有關(均P＜0.05);VEGF蛋白錶達與三陰性乳腺癌的腋窩淋巴結轉移、病理分期、Ki-67狀態和複髮轉移有關(均P＜0.05).MTDH和VEGF蛋白高錶達組的三陰性乳腺癌患者無病生存時間和總生存時間明顯低于MTDH和VEGF蛋白低錶達組,差異均有統計學意義(均P＜0.05).結論 在三陰性乳腺癌中,MTDH蛋白可能與VEGF蛋白對腫瘤血管生成的調節有關;MTDH和VEGF蛋白錶達有可能成為三陰性乳腺癌有價值的預後指標.
목적 탐토이점단백(MTDH)화혈관내피생장인자(VEGF)재삼음성유선암조직중적표체급기림상의의.방법 수집168례유선암(기중삼음성유선암112례화비삼음성유선암56례)、10례유선섬유선류화15례정상유선조직표본급림상자료,채용면역조화법검측MTDH화VEGF단백적표체,병결합림상자료분석기림상의의.결과 168례유선암조직중,MTDH화VEGF단백적고표체솔분별위57.1％(96/168)화49.4％ (83/168).MTDH화VEGF단백재삼음성유선암조직중적고표체솔분별위64.3％(72/112)화56.3％ (63/112),고우비삼음성유선암조직(42.9％화35.7％)、유선섬유선류(10.0％화20.0％)화정상유선조직(0.0％화0.0％),차이균유통계학의의(균P＜0.05).삼음성유선암조직중MTDH단백여VEGF단백적표체정저도정상관(r=0.356,P＜0.001).MTDH단백표체여삼음성유선암적종류대소、체질지수(BMI)、액와림파결전이、병리분기、p53상태、Ki-67상태화복발전이유관(균P＜0.05);VEGF단백표체여삼음성유선암적액와림파결전이、병리분기、Ki-67상태화복발전이유관(균P＜0.05).MTDH화VEGF단백고표체조적삼음성유선암환자무병생존시간화총생존시간명현저우MTDH화VEGF단백저표체조,차이균유통계학의의(균P＜0.05).결론 재삼음성유선암중,MTDH단백가능여VEGF단백대종류혈관생성적조절유관;MTDH화VEGF단백표체유가능성위삼음성유선암유개치적예후지표.
Objective To study the expression and clinical significance of MTDH and VEGF in triple-negative breast cancer (TNBC).Methods Tissue samples of 168 breast cancers (including 112 TNBC tissue and 56 non-TNBC tissue), 10 breast fibroadenomas and 15 normal breast tissues were collected.Postoperative specimens were examined by immunohistochemistry for MTDH and VEGF expression.The correlation between the expression of MTDH and VEGF and clinicopathological features was analyzed.Results MTDH and VEGF were expressed in 57.1％ and 49.4％ of breast cancer patients, 64.3％ and 56.3％ in TNBC patients, respectively, significantly higher than that in the non-TNBC tissues, breast fibroadenomas and normal breast tissues (P ＜ 0.05 for all).Statistically significant correlation was found between the MTDH and VEGF expressions (r =0.356, P＜0.001).Moreover, MTDH expression was correlated with tumor size, BMI index, lymph node metastasis, pathological stage, recurrence and metastasis, and the expression of p53 and Ki-67 proteins (P＜0.05 for all).The VEGF protein expression was correlated with lymph node metastasis, pathological staging, recurrence and metastasis, and the expression of Ki-67 protein (P＜0.05 for all).The patients with high expression of MTDH and VEGF showed a lower DFS and OS (P＜0.05 for both).Conclusions MTDH and VEGF expression may be correlated with tumor angiogenesis and progression and has the potential to be valuable prognostic factors in patients with TNBC.
