中华检验医学杂志
中華檢驗醫學雜誌
중화검험의학잡지
Chinese Journal of Laboratory Medicine
2015年
11期
761-764
,共4页
王静%郑群%余素飞%冯贻君%沈波
王靜%鄭群%餘素飛%馮貽君%瀋波
왕정%정군%여소비%풍이군%침파
宫颈肿瘤%Logistic模型%肿瘤标记,生物学%决策树
宮頸腫瘤%Logistic模型%腫瘤標記,生物學%決策樹
궁경종류%Logistic모형%종류표기,생물학%결책수
Uterine cervical neoplasms%Logistic models%Tumor markers,biological%Decision trees
目的 采用Logistic回归筛选与宫颈癌相关的血清肿瘤标志物,并进一步使用分类树卡方自动交互检测法(CHAID)建立鳞状上皮细胞癌相关抗原(Scc)在宫颈癌中的辅助诊断模型.方法 回顾性收集2010至2013年浙江省台州医院检测肿瘤标志物的宫颈癌初诊患者581例,宫颈良性疾病者342例,健康体检者341名,检测其糖类抗原199(CA199)、糖类抗原125(CA125)、CEA、SCC、AFP水平.先采用Logistic回归筛选出有统计学意义的肿瘤标志物,再进一步采用决策树CHAID法确定上述肿瘤标志物在辅助诊断宫颈癌中的价值.最后收集2014年1至12月SCC高于本研究得出的诊断值的子宫相关疾病患者共284例,计算其中的宫颈癌患者比例来验证决策树CHAID法结果.结果 Logistic回归结果显示5类可能与宫颈癌相关的肿瘤标志物中仅SCC具有统计学意义(Wald x2=22.120,P=0.000),OR值及其95％ CI为1.900(1.454 ～2.483).随着SCC数值的升高,宫颈癌患者的比例也逐渐增高,当SCC＞2.20 μg/L时,阳性预测值达94.7％.284例SCC高于2.20 μg/L的考虑子宫相关疾病的人群中,最终证实为宫颈癌的比例为95.1％(270例).结论 SCC对于官颈癌患者具有较好的辅助诊断价值.
目的 採用Logistic迴歸篩選與宮頸癌相關的血清腫瘤標誌物,併進一步使用分類樹卡方自動交互檢測法(CHAID)建立鱗狀上皮細胞癌相關抗原(Scc)在宮頸癌中的輔助診斷模型.方法 迴顧性收集2010至2013年浙江省檯州醫院檢測腫瘤標誌物的宮頸癌初診患者581例,宮頸良性疾病者342例,健康體檢者341名,檢測其糖類抗原199(CA199)、糖類抗原125(CA125)、CEA、SCC、AFP水平.先採用Logistic迴歸篩選齣有統計學意義的腫瘤標誌物,再進一步採用決策樹CHAID法確定上述腫瘤標誌物在輔助診斷宮頸癌中的價值.最後收集2014年1至12月SCC高于本研究得齣的診斷值的子宮相關疾病患者共284例,計算其中的宮頸癌患者比例來驗證決策樹CHAID法結果.結果 Logistic迴歸結果顯示5類可能與宮頸癌相關的腫瘤標誌物中僅SCC具有統計學意義(Wald x2=22.120,P=0.000),OR值及其95％ CI為1.900(1.454 ～2.483).隨著SCC數值的升高,宮頸癌患者的比例也逐漸增高,噹SCC＞2.20 μg/L時,暘性預測值達94.7％.284例SCC高于2.20 μg/L的攷慮子宮相關疾病的人群中,最終證實為宮頸癌的比例為95.1％(270例).結論 SCC對于官頸癌患者具有較好的輔助診斷價值.
목적 채용Logistic회귀사선여궁경암상관적혈청종류표지물,병진일보사용분류수잡방자동교호검측법(CHAID)건립린상상피세포암상관항원(Scc)재궁경암중적보조진단모형.방법 회고성수집2010지2013년절강성태주의원검측종류표지물적궁경암초진환자581례,궁경량성질병자342례,건강체검자341명,검측기당류항원199(CA199)、당류항원125(CA125)、CEA、SCC、AFP수평.선채용Logistic회귀사선출유통계학의의적종류표지물,재진일보채용결책수CHAID법학정상술종류표지물재보조진단궁경암중적개치.최후수집2014년1지12월SCC고우본연구득출적진단치적자궁상관질병환자공284례,계산기중적궁경암환자비례래험증결책수CHAID법결과.결과 Logistic회귀결과현시5류가능여궁경암상관적종류표지물중부SCC구유통계학의의(Wald x2=22.120,P=0.000),OR치급기95％ CI위1.900(1.454 ～2.483).수착SCC수치적승고,궁경암환자적비례야축점증고,당SCC＞2.20 μg/L시,양성예측치체94.7％.284례SCC고우2.20 μg/L적고필자궁상관질병적인군중,최종증실위궁경암적비례위95.1％(270례).결론 SCC대우관경암환자구유교호적보조진단개치.
Objective To explore the relationship between serum tumor markers and cervical cancer by using Logistic regression, and to further establish the diagnosis model of squamous cell carcinoma antigen (SCC) in cervical cancer by using chi-squared automatic interaction detector (CHAID) analysis of decision tree.Methods Total of 581 cases of cervical cancer,342 cases of cervical benign diseases and 341 cases of healthy controls who detected tumor markers in Taizhou Hospital of Zhejiang during 2010-2013, were retrospectively studied.The test results of carbohydrate antigen 199 (CA199), carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA), SCC, and alpha fetoprotein (AFP) were reviewed.The Logistic regression were firstly used in screening the related tumor markers of cervical cancer, and then the CHAID method of decision tree was used in determining the values of the related tumor markers on the diagnosis of cervical cancer.The SCC elevated cases of uterine disease from January 2014 to December 2014 were collected to verify the diagnostic value of SCC in cervical cancer patients.Results Logistic regression analysis showed that among the 5 tumor markers which might be associated with cervical cancer, SCC was the only one which had statistical significance between cervical cancer and cervical benign diseases (Wald x2 =22.120,P =0.000), the OR and its 95％ CI was 1.900 (1.454-2.483).With the SCC numerical increases, the proportion of patients with cervical cancer also gradually increased, when SCC ＞ 2.20 μg/L, the positive predictive value was 94.7％.In 284 cases of SCC higher than 2.20 μg/L who considered as uterus related diseases, there were 270 cases (95.1％) who were eventually confirmed as cervical cancer.Conclusion There was a good diagnostic value of SCC for cervical cancer patients.
