中华检验医学杂志
中華檢驗醫學雜誌
중화검험의학잡지
Chinese Journal of Laboratory Medicine
2015年
11期
746-750
,共5页
冠心病%N-乙酰神经氨酸%乳蛋白质类%C反应蛋白质%危险因素
冠心病%N-乙酰神經氨痠%乳蛋白質類%C反應蛋白質%危險因素
관심병%N-을선신경안산%유단백질류%C반응단백질%위험인소
Coronary disease%N-acetylneuraminic acid%Milk proteins%C-reactive protein%Risk factors
目的 探讨血清唾液酸(SA)、乳凝集素(MFG-E8)在预估冠状动脉粥样硬化性心脏病(CHD)的风险中的临床价值.方法 病例对照研究.收集2014年1至6月武汉大学人民医院心内科295例住院患者,根据其冠状动脉造影结果,分为对照组(78例,冠状动脉造影结果完全正常)和CHD组(217例,冠造结果显示至少1支主要冠状动脉狭窄大于30％),其中CHD组根据临床诊断分为稳定性心绞痛组、不稳定性心绞痛组以及心肌梗死组.检测血清SA、MFG-E8、超敏C反应蛋白(hs-CRP)以及血脂各项,统计分析各组血清SA、MFG-E8水平之间的差异,以及与冠心病狭窄程度(以Gensini评分表示)的相关性,采用二元logistic回归分析血清SA、MFG-E8与CHD危险性的关系.结果 与对照组相比,CHD组患者血清SA水平显著升高,MFG-E8水平明显降低(U值分别为4 402.5、2 736.0,P均＜0.001);AMI亚组SA显著高于StA亚组及UA亚组(U值分别为1329.0、957.5,P均＜0.001),AMI亚组MFG-E8显著低于StA亚组(U值为1 517.0,P＜0.001).Spearman相关性分析显示,血清SA水平与TG、hs-CRP水平及Gensini评分呈正相关,与MFG-E8水平呈负相关(r值分别为0.214、0.462、0.378、-0.322,P均＜0.01);MFG-E8水平与TG、hs-CRP水平及Gensini评分呈负相关(r值分别为-0.18、-0.425、-0.564,P均＜0.01).二元logistic回归分析显示,血清SA与CHD危险性呈正相关(OR值分别为4.782、5.319、4.179、3.832、3.648,P均＜0.001),血清MFG-E8与CHD危险性呈负相关(OR值分别为0.118、0.112、0.127、0.135、0.134,P均＜0.001).结论 血清SA越高,MFG-E8越低,患CHD的风险性越大,联合检测血清SA、MFG-E8可能是CHD诊断、综合评估狭窄程度及危险性的新指标.
目的 探討血清唾液痠(SA)、乳凝集素(MFG-E8)在預估冠狀動脈粥樣硬化性心髒病(CHD)的風險中的臨床價值.方法 病例對照研究.收集2014年1至6月武漢大學人民醫院心內科295例住院患者,根據其冠狀動脈造影結果,分為對照組(78例,冠狀動脈造影結果完全正常)和CHD組(217例,冠造結果顯示至少1支主要冠狀動脈狹窄大于30％),其中CHD組根據臨床診斷分為穩定性心絞痛組、不穩定性心絞痛組以及心肌梗死組.檢測血清SA、MFG-E8、超敏C反應蛋白(hs-CRP)以及血脂各項,統計分析各組血清SA、MFG-E8水平之間的差異,以及與冠心病狹窄程度(以Gensini評分錶示)的相關性,採用二元logistic迴歸分析血清SA、MFG-E8與CHD危險性的關繫.結果 與對照組相比,CHD組患者血清SA水平顯著升高,MFG-E8水平明顯降低(U值分彆為4 402.5、2 736.0,P均＜0.001);AMI亞組SA顯著高于StA亞組及UA亞組(U值分彆為1329.0、957.5,P均＜0.001),AMI亞組MFG-E8顯著低于StA亞組(U值為1 517.0,P＜0.001).Spearman相關性分析顯示,血清SA水平與TG、hs-CRP水平及Gensini評分呈正相關,與MFG-E8水平呈負相關(r值分彆為0.214、0.462、0.378、-0.322,P均＜0.01);MFG-E8水平與TG、hs-CRP水平及Gensini評分呈負相關(r值分彆為-0.18、-0.425、-0.564,P均＜0.01).二元logistic迴歸分析顯示,血清SA與CHD危險性呈正相關(OR值分彆為4.782、5.319、4.179、3.832、3.648,P均＜0.001),血清MFG-E8與CHD危險性呈負相關(OR值分彆為0.118、0.112、0.127、0.135、0.134,P均＜0.001).結論 血清SA越高,MFG-E8越低,患CHD的風險性越大,聯閤檢測血清SA、MFG-E8可能是CHD診斷、綜閤評估狹窄程度及危險性的新指標.
목적 탐토혈청타액산(SA)、유응집소(MFG-E8)재예고관상동맥죽양경화성심장병(CHD)적풍험중적림상개치.방법 병례대조연구.수집2014년1지6월무한대학인민의원심내과295례주원환자,근거기관상동맥조영결과,분위대조조(78례,관상동맥조영결과완전정상)화CHD조(217례,관조결과현시지소1지주요관상동맥협착대우30％),기중CHD조근거림상진단분위은정성심교통조、불은정성심교통조이급심기경사조.검측혈청SA、MFG-E8、초민C반응단백(hs-CRP)이급혈지각항,통계분석각조혈청SA、MFG-E8수평지간적차이,이급여관심병협착정도(이Gensini평분표시)적상관성,채용이원logistic회귀분석혈청SA、MFG-E8여CHD위험성적관계.결과 여대조조상비,CHD조환자혈청SA수평현저승고,MFG-E8수평명현강저(U치분별위4 402.5、2 736.0,P균＜0.001);AMI아조SA현저고우StA아조급UA아조(U치분별위1329.0、957.5,P균＜0.001),AMI아조MFG-E8현저저우StA아조(U치위1 517.0,P＜0.001).Spearman상관성분석현시,혈청SA수평여TG、hs-CRP수평급Gensini평분정정상관,여MFG-E8수평정부상관(r치분별위0.214、0.462、0.378、-0.322,P균＜0.01);MFG-E8수평여TG、hs-CRP수평급Gensini평분정부상관(r치분별위-0.18、-0.425、-0.564,P균＜0.01).이원logistic회귀분석현시,혈청SA여CHD위험성정정상관(OR치분별위4.782、5.319、4.179、3.832、3.648,P균＜0.001),혈청MFG-E8여CHD위험성정부상관(OR치분별위0.118、0.112、0.127、0.135、0.134,P균＜0.001).결론 혈청SA월고,MFG-E8월저,환CHD적풍험성월대,연합검측혈청SA、MFG-E8가능시CHD진단、종합평고협착정도급위험성적신지표.
Objective To discuss the effect and clinical value of serum sialic acid (SA) and lactadherin(MFG-E8) in the coronary atherosclerotic heart disease(CHD).Methods Selected 295 patients who visited to Wuhan University Renmin's Hospital cardiovascular medicine (from January to June, 2014), and then according to the results of coronary angiography divide the subjects into control group (n =78, the result of coronary angiography completely normal)and coronary heart disease group(n =217, the results of coronary angiography showed that one major coronary stenosis was more than 30％).Detected their serum level of lipid, SA, MFG-E8, hs-CRP index.At last, analyze the differences of SA and MFG-E8 between these groups, and the correlation with the severity of coronary stenosis (symbolize with Gensini score), use the binary logistic regression analysis to research the relationship among the serum level of SA, MFG-E8 and the risk of CHD.Results Compared with the control group, the patients with CHD have a higher level of serum SA and a lower level of MFG-E8 (U =4 402.5, 2 736.0 respectively,P ＜0.001);the AMI group has a higher level of serum SA than the StA and UA groups (U =1 329.0,957.5 respectively, P ＜0.001);the AMI group has a lower level of serum MFG-E8 than the StA groups (U =1517.0, P ＜ 0.001).The spearman correlation analysis showed that the serum SA has a positively correlation with the level of TG, hsCRP and Gensini score, and has a negatively correlated with the level of MFG-E8 (r =0.214, 0.462, 0.378,-0.322 respectively,P ＜0.01);the MFG-E8 has a negatively correlated with the level of TG, hsCRP and Gensini score (r =-0.18,-0.425,-0.564 respectively, P ＜0.01).Binary logistic regression analysis showed that there was a positive correlation between the serum SA and the risk of CHD (OD =4.782, 5.319, 4.179 3.832, 3.648 respectively, P ＜0.001), and the was a negative correlation between the serum MFG-E8 and the risk of CHD (OD =O.118, 0.112, 0.127, 0.135, 0.134 respectively, P ＜ 0.001).Conclusion With the serum SA rised and the MFG-E8 reduced, the risk of coronary heart disease was higher, combined detection these two indexes may be able to diagnose the CHD and assess the degree of stenosis and the risk of CHD.
