CAJ | 학술논문

选择性剪接是指真核细胞选择性地对前信使RNA (pre-mRNA)剪接位点的组合剪接加工,形成不同的成熟信使RNA(mRNA),从而使一个基因产生若干有独特结构和功能的蛋白质异构体的过程.其过程受多种顺式作用元件和反式作用因子的调控.近年发现异常选择性剪接在多种不同类型白血病患者体内普遍存在,与白血病的发生、发展及化疗抵抗等密切相关,在白血病诊断及治疗中有广阔的应用前景.
선택성전접시지진핵세포선택성지대전신사RNA (pre-mRNA)전접위점적조합전접가공,형성불동적성숙신사RNA(mRNA),종이사일개기인산생약간유독특결구화공능적단백질이구체적과정.기과정수다충순식작용원건화반식작용인자적조공.근년발현이상선택성전접재다충불동류형백혈병환자체내보편존재,여백혈병적발생、발전급화료저항등밀절상관,재백혈병진단급치료중유엄활적응용전경.
Alternative splicing is a process refering a pre-mRNA transforms to different mature mRNAs by different splicing sites combination, and then the mRNAs translate to various proteins.This process is regulated by a variety of cis acting elements and trans acting factors.Recent studies have shown that aberrant alternative splicing is prevalent in leukemia patients, and is closely associated with leukemic occurrence, development and chemotherapy resistance.This shows us that aberrant altemative splicing may be helpful to leukemia diagnosis and treatment.