中华眼底病杂志
中華眼底病雜誌
중화안저병잡지
Chinese Journal of Ocular Fundus Diseases
2015年
6期
560-563
,共4页
糖尿病视网膜病变/药物疗法%血管生成抑制剂/治疗应用%抗体,单克隆/治疗应用%血管内皮生长因子类
糖尿病視網膜病變/藥物療法%血管生成抑製劑/治療應用%抗體,單剋隆/治療應用%血管內皮生長因子類
당뇨병시망막병변/약물요법%혈관생성억제제/치료응용%항체,단극륭/치료응용%혈관내피생장인자류
Diabetic retinopathy/drug therapy%Angiogenesis inhibitors/therapeutic use%Antibodies,monoclonal/therapeutic use%Vascular endothelial growth factors
目的 观察增生型糖尿病视网膜病变(PDR)患眼玻璃体腔注射雷珠单抗(IVR)治疗前后房水血管内皮生长因子(VEGF)和色素上皮衍生因子(PEDF)的浓度变化.方法 临床确诊为PDR的20例患者25只眼(PDR组)及老年性白内障患者(对照组)21例25只眼纳入研究.两组患者的性别(x2=0.223)、年龄(Z=-1.555)、眼压(Z=-0.225)比较,差异无统计学意义(P＞0.05).PDR组患眼行常规IVR治疗;对照组患眼常规行白内障超声乳化手术.PDR组患眼于IVR治疗前及IVR治疗后7d、对照组患眼于手术前各抽取房水0.1 ml,采用酶联免疫吸附测定法检测房水VEGF、PEDF浓度.对两组患眼房水VEGF、PEDF浓度行相关性分析.结果 IVR治疗后PDR组患眼房水VEGF、PEDF浓度较IVR治疗前明显降低,差异有统计学意义(Z=-4.072、-4.319,P＜0.05).IVR治疗前PDR组患眼房水VEGF、PEDF浓度较对照组明显升高,差异有统计学意义(Z=-5.228、4.706,P＜0.05).与对照组比较,IVR治疗后PDR组患眼房水VEGF浓度无明显变化,差异无统计学意义(Z=-1.557,P＞0.05);而PEDF浓度仍偏高,差异有统计学意义(Z=-2.475,P＜0.05).IVR治疗前后PDR组患眼房水VEGF/PEDF浓度比值比较,差异有统计学意义(Z=-2.058,P＜0.05).IVR治疗前后PDR组患眼房水VEGF/PEDF浓度比值分别与对照组比较,差异均无统计学意义(Z=-0.456、-0.844,P＞0.05).相关性分析结果显示,IVR治疗前后PDR组患眼房水VEGF和PEDF浓度之间均无明显相关性(r=-0.195、-0.174,P＞0.05);对照组患眼房水VEGF和PEDF浓度之间也无明显相关性(r=0.286,P＞0.05).结论 PDR患眼房水中VEGF和PEDF浓度显著增高;经IVR治疗后,房水VEGF、PEDF浓度明显降低.
目的 觀察增生型糖尿病視網膜病變(PDR)患眼玻璃體腔註射雷珠單抗(IVR)治療前後房水血管內皮生長因子(VEGF)和色素上皮衍生因子(PEDF)的濃度變化.方法 臨床確診為PDR的20例患者25隻眼(PDR組)及老年性白內障患者(對照組)21例25隻眼納入研究.兩組患者的性彆(x2=0.223)、年齡(Z=-1.555)、眼壓(Z=-0.225)比較,差異無統計學意義(P＞0.05).PDR組患眼行常規IVR治療;對照組患眼常規行白內障超聲乳化手術.PDR組患眼于IVR治療前及IVR治療後7d、對照組患眼于手術前各抽取房水0.1 ml,採用酶聯免疫吸附測定法檢測房水VEGF、PEDF濃度.對兩組患眼房水VEGF、PEDF濃度行相關性分析.結果 IVR治療後PDR組患眼房水VEGF、PEDF濃度較IVR治療前明顯降低,差異有統計學意義(Z=-4.072、-4.319,P＜0.05).IVR治療前PDR組患眼房水VEGF、PEDF濃度較對照組明顯升高,差異有統計學意義(Z=-5.228、4.706,P＜0.05).與對照組比較,IVR治療後PDR組患眼房水VEGF濃度無明顯變化,差異無統計學意義(Z=-1.557,P＞0.05);而PEDF濃度仍偏高,差異有統計學意義(Z=-2.475,P＜0.05).IVR治療前後PDR組患眼房水VEGF/PEDF濃度比值比較,差異有統計學意義(Z=-2.058,P＜0.05).IVR治療前後PDR組患眼房水VEGF/PEDF濃度比值分彆與對照組比較,差異均無統計學意義(Z=-0.456、-0.844,P＞0.05).相關性分析結果顯示,IVR治療前後PDR組患眼房水VEGF和PEDF濃度之間均無明顯相關性(r=-0.195、-0.174,P＞0.05);對照組患眼房水VEGF和PEDF濃度之間也無明顯相關性(r=0.286,P＞0.05).結論 PDR患眼房水中VEGF和PEDF濃度顯著增高;經IVR治療後,房水VEGF、PEDF濃度明顯降低.
목적 관찰증생형당뇨병시망막병변(PDR)환안파리체강주사뢰주단항(IVR)치료전후방수혈관내피생장인자(VEGF)화색소상피연생인자(PEDF)적농도변화.방법 림상학진위PDR적20례환자25지안(PDR조)급노년성백내장환자(대조조)21례25지안납입연구.량조환자적성별(x2=0.223)、년령(Z=-1.555)、안압(Z=-0.225)비교,차이무통계학의의(P＞0.05).PDR조환안행상규IVR치료;대조조환안상규행백내장초성유화수술.PDR조환안우IVR치료전급IVR치료후7d、대조조환안우수술전각추취방수0.1 ml,채용매련면역흡부측정법검측방수VEGF、PEDF농도.대량조환안방수VEGF、PEDF농도행상관성분석.결과 IVR치료후PDR조환안방수VEGF、PEDF농도교IVR치료전명현강저,차이유통계학의의(Z=-4.072、-4.319,P＜0.05).IVR치료전PDR조환안방수VEGF、PEDF농도교대조조명현승고,차이유통계학의의(Z=-5.228、4.706,P＜0.05).여대조조비교,IVR치료후PDR조환안방수VEGF농도무명현변화,차이무통계학의의(Z=-1.557,P＞0.05);이PEDF농도잉편고,차이유통계학의의(Z=-2.475,P＜0.05).IVR치료전후PDR조환안방수VEGF/PEDF농도비치비교,차이유통계학의의(Z=-2.058,P＜0.05).IVR치료전후PDR조환안방수VEGF/PEDF농도비치분별여대조조비교,차이균무통계학의의(Z=-0.456、-0.844,P＞0.05).상관성분석결과현시,IVR치료전후PDR조환안방수VEGF화PEDF농도지간균무명현상관성(r=-0.195、-0.174,P＞0.05);대조조환안방수VEGF화PEDF농도지간야무명현상관성(r=0.286,P＞0.05).결론 PDR환안방수중VEGF화PEDF농도현저증고;경IVR치료후,방수VEGF、PEDF농도명현강저.
Objective To analyze the concentrations of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) in aqueous humor of patients with proliferative diabetic retinopathy (PDR) before and after intravitreal injection of ranibizumab.Methods Twenty-five eyes of 20 PDR patients were collected as the PDR group.Twenty-five eyes of 21 senile cataract patients were collected as the control group.There were no statistical significance in gender (x2 =0.223), age (Z=-1.555) and intraocular pressure (Z=0.225) between the two groups (P＞0.05).Samples of aqueous humor (0.1 ml) were collected just before and 7 days after the injection of ranibizumab in PDR group.Samples of aqueous (0.1 ml) humor were collected just before cataract surgery in control group.The concentrations of VEGF and PEDF in the aqueous humor were measured by enzyme-linked immunosorbent assay.Results The VEGF and PEDF concentration in the aqueous humor were reduced significantly after intravitreal injection of ranibizumab in PDR group (Z=-4.072,-4.319;P＜0.05).The concentrations of VEGF and PEDF in the aqueous humor before intravitreal injection of ranibizumab in PDR group were significantly higher than the control group (Z=-5.228, 4.706;P＜0.05).The VEGF concentration in the aqueous humor after intravitreal injection of ranibizumab in PDR group were similar to control group (Z=-1.557,P＞ 0.05).However, the concentration of PEDF in the aqueous humor after intravitreal injection of ranibizumab in PDR group still higher than control group (Z=-2.475, P＜0.05).The ratio of VEGF/PEDF before and after intravitreal injection of ranibizumab was statistically different (Z=-2.058, P＜0.05), but was the same between PDR group and control group (Z=-0.456,-0.844;P＞0.05).The aqueous humor concentrations of VEGF and PEDF were not significantly correlated with each other, neither in PDR group (r=-0.195,-0.174;P＞0.05) nor in control group (r=-0.286, P＞0.05).Conclusions Aqueous humor concentrations of VEGF and PEDF are significantly elevated in eyes with PDR.Intravitreal injection of ranibizumab significantly decreased the VEGF and PEDF in the aqueous humor after 7 days.
