中国实用医刊
中國實用醫刊
중국실용의간
Chinese Journal of Practical Medicine
2015年
24期
48-49
,共2页
风湿免疫病%生物制剂%视觉模拟评分%临床疗效
風濕免疫病%生物製劑%視覺模擬評分%臨床療效
풍습면역병%생물제제%시각모의평분%림상료효
Self-immunity rheumatism%Biologics%VAS scores%Clinical effects
目的 观察生物制剂治疗风湿免疫性疾病患者的临床疗效.方法 选取运城市中心医院治疗的风湿免疫病患者70例作为研究对象,采用数字随机法将患者分为两组,对照组行常规治疗,观察组在对照组基础上选取生物制剂治疗,行视觉模拟评分(VAS)和生活质量评分(QOL),观察C-反应蛋白(CRP)、血沉(ESR)变化情况,并评估临床疗效.结果 观察组治疗有效率为91.43％,显著高于对照组的71.43％,差异有统计学意义(P＜0.05).观察组治疗后发热、疼痛、肌肉乏力、皮疹等评分分别为(0.95±0.52)、(0.87±0.44)、(1.05±0.26)、(0.93±0.18)分,均显著低于对照组,差异有统计学意义(P＜0.05).观察组治疗后CRP水平为(9.46±7.51) mg/L,明显低于对照组,差异有统计学意义(P＜0.05).结论 在抗风湿基础上辅以生物制剂治疗风湿免疫病,可降低CRP、ESR水平,提高临床疗效.
目的 觀察生物製劑治療風濕免疫性疾病患者的臨床療效.方法 選取運城市中心醫院治療的風濕免疫病患者70例作為研究對象,採用數字隨機法將患者分為兩組,對照組行常規治療,觀察組在對照組基礎上選取生物製劑治療,行視覺模擬評分(VAS)和生活質量評分(QOL),觀察C-反應蛋白(CRP)、血沉(ESR)變化情況,併評估臨床療效.結果 觀察組治療有效率為91.43％,顯著高于對照組的71.43％,差異有統計學意義(P＜0.05).觀察組治療後髮熱、疼痛、肌肉乏力、皮疹等評分分彆為(0.95±0.52)、(0.87±0.44)、(1.05±0.26)、(0.93±0.18)分,均顯著低于對照組,差異有統計學意義(P＜0.05).觀察組治療後CRP水平為(9.46±7.51) mg/L,明顯低于對照組,差異有統計學意義(P＜0.05).結論 在抗風濕基礎上輔以生物製劑治療風濕免疫病,可降低CRP、ESR水平,提高臨床療效.
목적 관찰생물제제치료풍습면역성질병환자적림상료효.방법 선취운성시중심의원치료적풍습면역병환자70례작위연구대상,채용수자수궤법장환자분위량조,대조조행상규치료,관찰조재대조조기출상선취생물제제치료,행시각모의평분(VAS)화생활질량평분(QOL),관찰C-반응단백(CRP)、혈침(ESR)변화정황,병평고림상료효.결과 관찰조치료유효솔위91.43％,현저고우대조조적71.43％,차이유통계학의의(P＜0.05).관찰조치료후발열、동통、기육핍력、피진등평분분별위(0.95±0.52)、(0.87±0.44)、(1.05±0.26)、(0.93±0.18)분,균현저저우대조조,차이유통계학의의(P＜0.05).관찰조치료후CRP수평위(9.46±7.51) mg/L,명현저우대조조,차이유통계학의의(P＜0.05).결론 재항풍습기출상보이생물제제치료풍습면역병,가강저CRP、ESR수평,제고림상료효.
Objective To observe the clinical effects of biologics on self-immunity rheumatism.Methods Seventy patients with self-immunity rheumatism were randomly divided into the test group and the control group.The control group were given routine therapy and the test group were treated with biologics based on control group.QOL and VAS were graded and the changes of CRP, ESR were observed.Results The response rate of test group (91.43％) were significantly higher than that of control group (71.43％, P ＜0.05).The scores of fever(0.95 ±0.52), pain(0.87 ±0.44), muscle weakness (1.05 ± 0.26)and skin rash(0.93±0.18) were significantly lower than those of control group (P ＜0.05).The CRP level of test group [(9.46 ± 7.51) mg/L] was significantly lower than that of control group (P ＜ 0.05).Conclusions Biologics combined with general anti-rheumatism therapy can decrease CPR level and improve the clinical effects on self-immunity rheumatism.
