中国药物与临床
中國藥物與臨床
중국약물여림상
Chinese Remedies & Clinics
2015年
11期
1533-1535
,共3页
冠状动脉疾病%血清胱抑素C%肾功能%心功能
冠狀動脈疾病%血清胱抑素C%腎功能%心功能
관상동맥질병%혈청광억소C%신공능%심공능
Coronary disease%Serum cystatin C%Renal function%Cardiac function
目的 探讨冠心病患者血清胱抑素C水平与心肾功能的关系.方法 选取2011年8月至2014年10月来我院就诊确诊的冠心病患者98例,依据造影结果分为单支血管病变组(49例)和多支血管病变组(49例),采用免疫比浊法检测胱抑素C(Cys-C)、β2微球蛋白(β2MG)水平,超声心动仪测定左心室舒张末期直径(LVEDD),采用辛普森法测得左心室射血分数(LVEF),比较分析2组患者指标水平,并进行相关性分析.结果多支血管病变组患者Cys-C、LVEF、LVEDD、β2MG、尿素氮(BUN)、血肌酐(Scr)的水平均显著高于单支血管病变组(P<0.05);Cys-C与LVEF水平呈负相关(r=-0.746,P<0.05),Cys-C与LVEDD水平呈正相关(r=0.638,P<0.05), Cys-C与β2MG、BUN、Scr水平均呈正相关(r=0.384、0.729、0.455,P<0.05);LVEF与β2MG、BUN、Scr水平均呈负相关 (r=-0.283、-0.705、-0.692,P<0.05),LVEDD与β2MG、BUN、Scr水平无显著相关性 (r=0.015、0.012、0.018,P>0.05).结论 冠心病患者血清胱抑素C水平与心、肾功能有关,可反映早期肾损伤及心室重构.
目的 探討冠心病患者血清胱抑素C水平與心腎功能的關繫.方法 選取2011年8月至2014年10月來我院就診確診的冠心病患者98例,依據造影結果分為單支血管病變組(49例)和多支血管病變組(49例),採用免疫比濁法檢測胱抑素C(Cys-C)、β2微毬蛋白(β2MG)水平,超聲心動儀測定左心室舒張末期直徑(LVEDD),採用辛普森法測得左心室射血分數(LVEF),比較分析2組患者指標水平,併進行相關性分析.結果多支血管病變組患者Cys-C、LVEF、LVEDD、β2MG、尿素氮(BUN)、血肌酐(Scr)的水平均顯著高于單支血管病變組(P<0.05);Cys-C與LVEF水平呈負相關(r=-0.746,P<0.05),Cys-C與LVEDD水平呈正相關(r=0.638,P<0.05), Cys-C與β2MG、BUN、Scr水平均呈正相關(r=0.384、0.729、0.455,P<0.05);LVEF與β2MG、BUN、Scr水平均呈負相關 (r=-0.283、-0.705、-0.692,P<0.05),LVEDD與β2MG、BUN、Scr水平無顯著相關性 (r=0.015、0.012、0.018,P>0.05).結論 冠心病患者血清胱抑素C水平與心、腎功能有關,可反映早期腎損傷及心室重構.
목적 탐토관심병환자혈청광억소C수평여심신공능적관계.방법 선취2011년8월지2014년10월래아원취진학진적관심병환자98례,의거조영결과분위단지혈관병변조(49례)화다지혈관병변조(49례),채용면역비탁법검측광억소C(Cys-C)、β2미구단백(β2MG)수평,초성심동의측정좌심실서장말기직경(LVEDD),채용신보삼법측득좌심실사혈분수(LVEF),비교분석2조환자지표수평,병진행상관성분석.결과다지혈관병변조환자Cys-C、LVEF、LVEDD、β2MG、뇨소담(BUN)、혈기항(Scr)적수평균현저고우단지혈관병변조(P<0.05);Cys-C여LVEF수평정부상관(r=-0.746,P<0.05),Cys-C여LVEDD수평정정상관(r=0.638,P<0.05), Cys-C여β2MG、BUN、Scr수평균정정상관(r=0.384、0.729、0.455,P<0.05);LVEF여β2MG、BUN、Scr수평균정부상관 (r=-0.283、-0.705、-0.692,P<0.05),LVEDD여β2MG、BUN、Scr수평무현저상관성 (r=0.015、0.012、0.018,P>0.05).결론 관심병환자혈청광억소C수평여심、신공능유관,가반영조기신손상급심실중구.
Objective To investigate the correlation between serum cystatin C level and heart and kidney func-tion in patients with coronary heart disease (CHD). Methods A total of 98 patients diagnosed with CHD in our hos-pital between August 2011 and October 2014 were included in the study, and divided into the single-vessel disease group (n=49) and multi-vessel disease group (n=49) based on angiography. Immunoturbidimetry was used to determine cystatin C (Cys-C) and β2-microglobulin (β2MG) level. The left ventricular end-diastolic diameter (LVEDD) was deter-mined by echocardiography, and the left ventricular ejection fraction (LVEF) was determined by Simpson method. The index levels in the two groups were compared, and the correlation was analyzed. Results The Cys-C, LVEF, LVEDD,β2MG, BUN and Scr levels in patients with multi-vessel disease were significantly higher than those in patients with single-vessel disease (P<0.05). Cys-C and LVEF levels was negatively correlated (r=-0.746, P<0.05). Cys-C and LVEDD levels was positively correlated (r=0.638, P<0.05). Cys-C was positively correlated with β2MG, BUN and Scr levels (r=0.384, 0.729, 0.455, P<0.05). LVEF was negatively correlated withβ2MG, BUN and Scr levels (r=-0.283,-0.705,-0.692, P<0.05). LVEDD and β2MG, BUN, Scr levels were not significantly correlated (r=0.015, 0.012, 0.018, P>0.05). Conclusion Serum Cys-C levels may correlated with heart and kidney function in CHD patients, which reflects early renal damage and ventricular remodeling.
