航空航天医学杂志
航空航天醫學雜誌
항공항천의학잡지
Journal of Aerospace Medicine
2015年
11期
1334-1336
,共3页
李丽颖%朱颖%张伟%李锐
李麗穎%硃穎%張偉%李銳
리려영%주영%장위%리예
心房颤动%C-反应蛋白(CRP)%细胞间粘附因子1(ICAM-1)%可溶性P选择素(sPs)%辛伐他汀
心房顫動%C-反應蛋白(CRP)%細胞間粘附因子1(ICAM-1)%可溶性P選擇素(sPs)%辛伐他汀
심방전동%C-반응단백(CRP)%세포간점부인자1(ICAM-1)%가용성P선택소(sPs)%신벌타정
atrial fibrillation%C-reactive protein (CRP)%intercellular adhesion molecule 1 (ICAM-1)%soluble P selectin (sPs)%simvastatin
目的 通过测定炎症因子 C-反应蛋白 (CRP)、细胞间粘附因子1(ICAM-1)、可溶性P选择素(sPs)水平,探讨AF与炎症之间的相互关系,并观察辛伐他汀对AF的炎症反应的影响及AF的复发. 方法 通过测定房颤患者血清中的CRP、ICAM-1、sPs水平,与窦性心律组进行比较,同时测定应用辛伐他汀前后炎症因子水平的变化,观察AF复发的情况. 结果 房颤组CRP、ICAM-1、sPs水平高于正常对照组;持续性和永久性房颤组CRP、ICAM-1、sPs水平高于阵发性房颤组;辛伐他汀组CRP、ICAM-1、sPs水平在治疗后二周均低于治疗前,差异有统计学意义( P<0.05 ) ,且辛伐他汀组AF复发率低于对照组,差异有统计学意义( P<0.05 ). 结论 AF与炎症反应有相关性,炎症可能是AF的致病因素,辛伐他汀可以降低AF患者血浆炎症指标水平,减少AF的早期复发.
目的 通過測定炎癥因子 C-反應蛋白 (CRP)、細胞間粘附因子1(ICAM-1)、可溶性P選擇素(sPs)水平,探討AF與炎癥之間的相互關繫,併觀察辛伐他汀對AF的炎癥反應的影響及AF的複髮. 方法 通過測定房顫患者血清中的CRP、ICAM-1、sPs水平,與竇性心律組進行比較,同時測定應用辛伐他汀前後炎癥因子水平的變化,觀察AF複髮的情況. 結果 房顫組CRP、ICAM-1、sPs水平高于正常對照組;持續性和永久性房顫組CRP、ICAM-1、sPs水平高于陣髮性房顫組;辛伐他汀組CRP、ICAM-1、sPs水平在治療後二週均低于治療前,差異有統計學意義( P<0.05 ) ,且辛伐他汀組AF複髮率低于對照組,差異有統計學意義( P<0.05 ). 結論 AF與炎癥反應有相關性,炎癥可能是AF的緻病因素,辛伐他汀可以降低AF患者血漿炎癥指標水平,減少AF的早期複髮.
목적 통과측정염증인자 C-반응단백 (CRP)、세포간점부인자1(ICAM-1)、가용성P선택소(sPs)수평,탐토AF여염증지간적상호관계,병관찰신벌타정대AF적염증반응적영향급AF적복발. 방법 통과측정방전환자혈청중적CRP、ICAM-1、sPs수평,여두성심률조진행비교,동시측정응용신벌타정전후염증인자수평적변화,관찰AF복발적정황. 결과 방전조CRP、ICAM-1、sPs수평고우정상대조조;지속성화영구성방전조CRP、ICAM-1、sPs수평고우진발성방전조;신벌타정조CRP、ICAM-1、sPs수평재치료후이주균저우치료전,차이유통계학의의( P<0.05 ) ,차신벌타정조AF복발솔저우대조조,차이유통계학의의( P<0.05 ). 결론 AF여염증반응유상관성,염증가능시AF적치병인소,신벌타정가이강저AF환자혈장염증지표수평,감소AF적조기복발.
Objective Through the determination of inflammatory factors of C -reaction protein ( CRP) , intercellu-lar adhesion molecule 1 (ICAM-1), soluble P selectin (sPs) level, and to explore the relationship between AF and in-flammation, and to observe the effect of simvastatin on the inflammatory reaction of AF and recurrence of AF .Methods Through the determination of atrial fibrillation in patients with CRP , ICAM-1, sPs levels, compared with the sinus rhythm group , measured the levels of inflammatory factors before and after the application of simvastatin , observed the re-currence of AF.Results The atrial fibrillation group , CRP, ICAM -1, sPs levels higher than the normal control group;persistent and permanent AF group , CRP, ICAM-1, sPs levels were significantly higher in patients with parox-ysmal atrial fibrillation group;simvastatin group CRP, ICAM-1, sPs levels in two weeks after treatment were lower than those before treatment , the difference was statistically significant ( P<0.05 ) , and simvastatin group AF recurrence rate was lower than the control group , the difference was statistically significant (P<0.05).Conclusions There is a corre-lation between AF and inflammation , inflammation may be an etiological factor of AF , simvastatin can reduce the inflam-matory markers level in plasma of patients with AF , reduce the early recurrence of AF .