CAJ | 학술논문

目的观察自体外周血干细胞(APBSC)移植对乙型肝炎肝硬化失代偿期患者肝脏声脉冲辐射力成像值(ARFI)的影响. 方法采用前瞻性随机对照的方法,将68例入组患者随机分组,33例为治疗组,综合内科治疗基础上接受APBSC移植治疗,35例为对照组,单纯内科综合治疗.观察患者移植后12周、24周、36周、48周血总胆红素、凝血酶原时间(PT)、白蛋白(Alb)水平和脾脏大小、肝脏ARFI等改变,并与移植治疗前及同期对照组比较.据资料不同分别用t检验、非参数检验或x2检验.结果治疗组患者治疗后24周、36周、48周Alb、PT改善,36周、48周脾脏大小、肝脏ARFI指数与治疗前及对照组比较改善.移植后36周、48周脾脏长度分别为(140.09±23.05)mm、(139.55±24.12)mm,与移植前[(149.36±24.56)mm]差异有统计学意义(t值分别为3.43、-2.21,P＜0.05),与同期对照组[(150.26±18.27) mm、(151.66±19.76) mm]比较,差异有统计学意义(t值分别为-2.02、-2,27,P＜0.05).移植后36周、48周ARFI分别为(2.21±0.43)m/s、(2.19±0.43)m/s,与移植前[(2.49±0.31) m/s]差异有统计学意义(t=3.00,P=0.005;t=3.21,P=0.003),与同期对照组比较差异有统计学意义(P＜0.05).结论 APBSC移植治疗能够改善乙型肝炎肝硬化失代偿期患者的肝功能,肝脏ARFI指数及肝脏纤维化程度.
목적 관찰자체외주혈간세포(APBSC)이식대을형간염간경화실대상기환자간장성맥충복사력성상치(ARFI)적영향. 방법 채용전첨성수궤대조적방법,장68례입조환자수궤분조,33례위치료조,종합내과치료기출상접수APBSC이식치료,35례위대조조,단순내과종합치료.관찰환자이식후12주、24주、36주、48주혈총담홍소、응혈매원시간(PT)、백단백(Alb)수평화비장대소、간장ARFI등개변,병여이식치료전급동기대조조비교.거자료불동분별용t검험、비삼수검험혹x2검험.결과 치료조환자치료후24주、36주、48주Alb、PT개선,36주、48주비장대소、간장ARFI지수여치료전급대조조비교개선.이식후36주、48주비장장도분별위(140.09±23.05)mm、(139.55±24.12)mm,여이식전[(149.36±24.56)mm]차이유통계학의의(t치분별위3.43、-2.21,P＜0.05),여동기대조조[(150.26±18.27) mm、(151.66±19.76) mm]비교,차이유통계학의의(t치분별위-2.02、-2,27,P＜0.05).이식후36주、48주ARFI분별위(2.21±0.43)m/s、(2.19±0.43)m/s,여이식전[(2.49±0.31) m/s]차이유통계학의의(t=3.00,P=0.005;t=3.21,P=0.003),여동기대조조비교차이유통계학의의(P＜0.05).결론 APBSC이식치료능구개선을형간염간경화실대상기환자적간공능,간장ARFI지수급간장섬유화정도.
Objective To perform a prospective study the effects of autologous peripheral blood stem cell (APBSC) transplantation on acoustic radiation force impulse (ARFI) in patients with hepatitis B virus (HBV)-related decompensated cirrhosis.Methods A total of 68 hospitalized patients with HBV-related decompensated cirrhosis undergoing conventional treatment were included in the study.Thirty-three of these patients also received APBSC transplantation therapy (treatment group) and 35 did not (control group).The treatment group was observed for postoperative adverse reaction, and changes (pre-vs.post-treatment) in total bilirubin, prothrombin time (PT), albumin (Alb), spleen size and ARFI imaging findings.Statistical analyses were carried out using the t-test, non-parametric test, and chi-square test.Results The patients who received APBSC transplantation showed improving levels of Alb and PT, but not of total bilirubin, at postoperative weeks 24, 36 and 48, and reduced spleen length and ARFI findings at postoperative weeks 36 and 48.Compared to the baseline data (week 0) for the treatment group and to the data for the control groups, these differences were statistically significant (P ＜ 0.05).Conclusions APBSC transplantation can reduce ARFI imaging findings and improve the pathology of liver fibrosis in patients with HBV-related decompensated cirrhosis.